Polarographic reduction of adenine and its 9-(?,?-dihydroxy-2-alkyl) derivatives

1977 ◽  
Vol 13 (12) ◽  
pp. 1340-1343
Author(s):  
V. P. Kadysh ◽  
Ya. P. Stradyn' ◽  
I. N. Goncharova
Keyword(s):  
Polarographic Reduction ◽  
Alkyl Derivatives

Estimate of Hyperconjugation Strength in Alkylaromatics and Unsaturated Hydrocarbons Derived from Refractometric Data

2020 ◽  
Vol 23 (23) ◽  
pp. 2598-2613
Author(s):  
Boris A. Zaitsev
Keyword(s):  
Quantitative Estimation ◽  
Physical Phenomenon ◽  
Unsaturated Hydrocarbons ◽  
Resonance Effects ◽  
Alkyl Derivatives ◽  
Retrospective View ◽  
Scientific Papers ◽  
Polycyclic Aromatic ◽  
Qualitative Measure ◽  
Steric Inhibition Of Resonance

: A retrospective view of exaltation of refraction observed for many unsaturated and aromatic compounds demonstrates that this physical phenomenon is undeservedly considered only as a qualitative measure of conjugation. This mini-review discusses numerous papers by the author that have been published earlier in inaccessible periodicals and collections of scientific papers. Using a great number of illustrations, the author shows that this parameter can be successfully used for quantitative estimate of resonance effects in organic and polymer chemistry. The methods for derivation of strictly additive atomic and group refraction constants are described; these constants were subsequently used as a tool that allowed quantitative estimation of resonance effects in mono-, di-, tri- and polyalkylbenzenes, alkylnaphthalenes, some alkyl derivatives of unsaturated hydrocarbons. These effects cause strictly fixed increase in refraction of carbon atoms in different structural modifications (graphene, fullerene, diamond) and in polycyclic aromatic hydrocarbons. The relevant results regarding quantitative estimation of degree of steric inhibition of resonance in sterically hindered ortho-dialkylbenzenes, 1,2,3- trialkyl-, 1,2,3,4-tetraalkyl-, and 1,2,3,4,5-polyalkylbenzenes accumulated by the author are summarized.

Synthesis and Biological Evaluation of Scutellarein Alkyl Derivatives as Preventing Neurodegenerative Agents with Improved Lipid Soluble Properties

2019 ◽  
Vol 15 (7) ◽  
pp. 771-780
Author(s):  
He-Min Li ◽  
Ting Gu ◽  
Wen-Yu Wu ◽  
Shao-Peng Yu ◽  
Tian-Yuan Fan ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Neuronal Damage ◽  
Thiobarbituric Acid ◽  
Rat Hepatocytes ◽  
Biological Evaluation ◽  
Thiobarbituric Acid Reactive Substance ◽  
Alkyl Derivatives ◽  
Promising Therapeutic Approach ◽  
Microsomal Membranes

Background: Exogenous antioxidants are considered as a promising therapeutic approach to treat neurodegenerative diseases since they could prevent and/or minimize the neuronal damage by oxidation. Objective: Three series of lipophilic compounds structurally based on scutellarein (2), which is one metabolite of scutellarin (1) in vivo, have been designed and synthesized. Methods: Their antioxidant activity was evaluated by detecting the 2-thiobarbituric acid reactive substance (TBARS) produced in the ferrous salt/ascorbate-induced autoxidation of lipids, which were present in microsomal membranes of rat hepatocytes. The lipophilicity of these compounds indicated as partition coefficient between n-octanol and buffer was investigated by ultraviolet (UV) spectrophotometer. Results: This study indicated that compound 5e which had a benzyl group substituted at the C4'- OH position showed a potent antioxidant activity and good lipophilicity. Conclusion: 5e could be an effective candidate for preventing or reducing the oxidative status associated with the neurodegenerative processes.

Polarographic reduction of some diaziridines

1965 ◽  
Vol 30 (12) ◽  
pp. 4178-4183 ◽  
Author(s):  
Yu. P. Kitaev ◽  
G. K. Budnikov
Keyword(s):  
Polarographic Reduction

Solvent effects on the mechanism of polarographic reduction of nitroalkanes

1971 ◽  
Vol 36 (2) ◽  
pp. 730-739 ◽  
Author(s):  
G. Battistuzzi Gavioli ◽  
G. Grandi ◽  
R. Andreoli
Keyword(s):  
Solvent Effects ◽  
Polarographic Reduction
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