The differential diagnosis of nasal mucosal swelling and adenoidal hyperplasia using two- and three-parameter discriminant functions

1989 ◽  
Vol 246 (2) ◽  
pp. 83-88 ◽  
Author(s):  
A. Ayiomamitis ◽  
L. Parker
Keyword(s):  
Differential Diagnosis ◽  
Discriminant Functions ◽  
Nasal Mucosal Swelling

scholarly journals Discriminant value of %microcytic cells/%hypochromic cells ratio in the differential diagnosis of microcytic anemia

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Eloisa Urrechaga
Keyword(s):  
Differential Diagnosis ◽  
Area Under The Curve ◽  
Microcytic Anemia ◽  
Deficiency Anemia ◽  
Youden Index ◽  
Discriminant Functions ◽  
False Negatives ◽  
Mean Cell Volume ◽  
Group 5 ◽  
Validation Set

The Mindray 6800 Plus analyzer reports red cells (RBC) extended parameters, which represent the subsets of erythrocytes. We aimed to evaluate the reliability of RBC extended parameters in the differential diagnosis of microcytic anemia. The learning set comprised samples from 250 patients with microcytic anemia mean cell volume <80 fL. MH ratio (%microcytic cells/%hypochromic cells) and other discriminant functions were calculated. Optimal cut offs were established using receiver operator curves. This value was used in the validation set of 135 patients 50 carriers and 85 with mild iron deficiency anemia (IDA). Area under the curve 0.945 (95% confidence interval 0.890 to 0.977), cut off >10 rendered the best Youden index (0.798), sensitivity 93.2%, specificity 86.2%. In the validation set using MH ratio >10, 45 in 50 patients were correctly classified as carriers. All of 40 beta carriers were correctly classified, while the 5 false negatives resulted to be alpha carriers. In the IDA group 5 patients had MH ratio >10 and thus considered carriers, but all of them had Hyper <3%. The combination of MH ratio >10 and %Hyper <3% correctly classified 100% of IDA patients. An algorithm derived from RBC extended parameters provided by the Mindray 6800 Plus analyzer could be a useful tool in the differential diagnosis of microcytic anemia.

Discriminant functions in differential diagnosis of hypercalcemic patients

1990 ◽  
Vol 36 (2) ◽  
pp. 358-361 ◽  
Author(s):  
J A Gibb ◽  
S A Ogston ◽  
C R Paterson ◽  
J R Evans
Keyword(s):  
Differential Diagnosis ◽  
Rank Order ◽  
Calcium Excretion ◽  
Discriminant Functions ◽  
Plasma Phosphate ◽  
Plasma Albumin ◽  
Biochemical Assays ◽  
Glomerular Filtrate ◽  
Plasma And Urine Samples ◽  
Plasma Chloride

Abstract Using readily available biochemical assays of plasma and urine constituents, we have defined discriminant functions useful as a guide to the differential diagnosis of patients with hypercalcemia. The decreasing rank order of contribution of the variables to the discriminant functions was as follows: plasma albumin, plasma phosphate, plasma chloride, log10 (calcium excretion per liter of glomerular filtrate), and log10 (plasma gamma-glutamyltransferase). Discriminant functions have been defined for patients with values for plasma creatinine above and below 185 mumol/L, and for practical conditions in which plasma and urine samples, or plasma samples only, are available.

scholarly journals On the Transportability of Linear Discriminant Functions

1982 ◽  
Vol 19 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Martin R Holland ◽  
Anthony G Jacobs
Keyword(s):  
Alkaline Phosphatase ◽  
Differential Diagnosis ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Discriminant Functions ◽  
Linear Discriminant

Different methods can give different results for the same analyte, and inconsistent answers may be obtained if such results are used in linear discriminant functions. This is an important factor to consider when transporting linear discriminant functions from one laboratory to another; the example of alkaline phosphatase activity and the differential diagnosis of hypercalcaemia has recently been given. This study shows that results obtained by the method recommended by the Scandinavian Committee on Enzymes for alkaline phosphatase may be used in the calculation of the discriminant functions used for the differential diagnosis of hypercalcaemia and considers other factors that may affect the discrimination. It is concluded that, with care, linear discriminant functions may be transported from one laboratory to another.

DISCRIMINANT FUNCTIONS FOR THE DIFFERENTIAL DIAGNOSIS OF HYPERCALCÆMIA

The Lancet ◽  
1980 ◽  
Vol 316 (8189) ◽  
pp. 322-323 ◽  
Author(s):  
A.G. Jacobs ◽  
M.R. Holland
Keyword(s):  
Differential Diagnosis ◽  
Discriminant Functions

DISCRIMINANT FUNCTIONS IN DIFFERENTIAL DIAGNOSIS OF HYPERCALCÆMIA

The Lancet ◽  
1971 ◽  
Vol 297 (7713) ◽  
pp. 1314-1319 ◽  
Author(s):  
Patricia Fraser ◽  
Michael Healy ◽  
Natasha Rose ◽  
Lyal Watson
Keyword(s):  
Differential Diagnosis ◽  
Discriminant Functions

Tumor Diagnosis

1982 ◽  
Vol 40 ◽  
pp. 262-265
Author(s):  
Bruce Mackay
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Differential Diagnosis ◽  
Light Microscopy ◽  
Clinical Examination ◽  
Ultrastructural Study ◽  
Diagnostic Procedures ◽  
Specific Diagnosis ◽  
Transmission Electron ◽  
Microscopic Diagnosis

The broadest application of transmission electron microscopy (EM) in diagnostic medicine is the identification of tumors that cannot be classified by routine light microscopy. EM is useful in the evaluation of approximately 10% of human neoplasms, but the extent of its contribution varies considerably. It may provide a specific diagnosis that can not be reached by other means, but in contrast, the information obtained from ultrastructural study of some 10% of tumors does not significantly add to that available from light microscopy. Most cases fall somewhere between these two extremes: EM may correct a light microscopic diagnosis, or serve to narrow a differential diagnosis by excluding some of the possibilities considered by light microscopy. It is particularly important to correlate the EM findings with data from light microscopy, clinical examination, and other diagnostic procedures.

The Preschool Stuttering Screen for Health Care Professionals

2011 ◽  
Vol 21 (2) ◽  
pp. 59-62
Author(s):  
Joseph Donaher ◽  
Christina Deery ◽  
Sarah Vogel
Keyword(s):  
Risk Factors ◽  
Health Care ◽  
Differential Diagnosis ◽  
Preschool Children ◽  
Health Care Professionals ◽  
Healthcare Professionals ◽  
Evidence Based ◽  
Developmental Profile

Healthcare professionals require a thorough understanding of stuttering since they frequently play an important role in the identification and differential diagnosis of stuttering for preschool children. This paper introduces The Preschool Stuttering Screen for Healthcare Professionals (PSSHP) which highlights risk factors identified in the literature as being associated with persistent stuttering. By integrating the results of the checklist with a child’s developmental profile, healthcare professionals can make better-informed, evidence-based decisions for their patients.

The Effect of Sensori-Neural Hearing Loss on Threshold-Duration Functions

1968 ◽  
Vol 11 (4) ◽  
pp. 842-852 ◽  
Author(s):  
H. N. Wright
Keyword(s):  
Hearing Loss ◽  
Differential Diagnosis ◽  
Time Constant ◽  
Present Series ◽  
Auditory Disorders ◽  
Threshold Duration

Previous findings on the threshold for tones as a function of their duration have suggested that such functions may be systematically affected by sensori-neural hearing losses of cochlear origin. The present series of investigations was designed to explore this relation further and to determine also whether the amount of hearing loss present has any effect upon the results which are obtained. Preliminary studies were also carried out on a conductively impaired listener to indicate whether hearing losses of this type affect the threshold-duration function. The results indicate that the threshold-duration function is systematically affected by sensori-neural hearing losses of cochlear origin. This effect is manifested by a progressive shortening of the time constant relating threshold to duration and is not uniquely related to the amount of hearing loss present. The results obtained from the conductively impaired listener suggested that this type of hearing loss has no effect on the threshold-duration function, thereby implying that such functions may contribute significantly to the differential diagnosis of auditory disorders.

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