Effects of protein kinase C activators on mouse skin in vivo

1988 ◽  
Vol 280 (3) ◽  
pp. 182-184 ◽  
Author(s):  
S. Inohara ◽  
H. Tateishi ◽  
Y. Takeda ◽  
Y. Tanaka ◽  
S. Sagami
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Mouse Skin ◽  
Kinase C ◽  
Protein Kinase C Activators

Purification and identification of creatine phosphokinase B as a substrate of protein kinase C in mouse skin in vivo

1990 ◽  
Vol 173 (1) ◽  
pp. 351-357 ◽  
Author(s):  
Kazuhiro Chida ◽  
Kohji Kasahara ◽  
Makoto Tsunenaga ◽  
Yohko Kohno ◽  
Shuhei Yamada ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Creatine Phosphokinase ◽  
Mouse Skin ◽  
Kinase C

Comparison of octahydromezerein and mezerein as protein kinase C activators and as mouse skin tumor promoters

1989 ◽  
Vol 10 (10) ◽  
pp. 1937-1941 ◽  
Author(s):  
Sharkey Nancy A. ◽  
Henry Hennings ◽  
Stuart H. Yuspa ◽  
Tsutsumi Blumberg
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Mouse Skin ◽  
Skin Tumor ◽  
Tumor Promoters ◽  
Kinase C ◽  
Protein Kinase C Activators

Lack of an effect of novel inhibitors with high specificity for protein kinase C on the action of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo

1995 ◽  
Vol 16 (1) ◽  
pp. 107-111 ◽  
Author(s):  
M. Gschwendt ◽  
G. Fürstenberger ◽  
H. Leibersperger ◽  
W. Kittstein ◽  
D. Lindner ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phorbol Ester ◽  
Mouse Skin ◽  
High Specificity ◽  
Kinase C

Chronic treatment by the calcium channel blocker ± PN 200-110 in the rat counteracts the stimulations of pituitary weight, prolactin release and pituitary C-kinase activity induced by a chronic estradiol treatment, in vivo

1990 ◽  
Vol 122 (3) ◽  
pp. 403-408
Author(s):  
Ph. Touraine ◽  
P. Birman ◽  
F. Bai-Grenier ◽  
C. Dubray ◽  
F. Peillon ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Plasma Prolactin ◽  
Estradiol Treatment ◽  
Kinase C ◽  
Protein Kinase C Activity

Abstract In order to investigate whether a calcium channel blocker could modulate the protein kinase C activity in normal and estradiol pretreated rat pituitary, female Wistar rats were treated or not (controls) with ± PN 200-110 (3 mg · kg−1 · day−1, sc) for 8 days or with estradiol cervical implants for 8 or 15 days, alone or in combination with PN 200-110 the last 8 days. Estradiol treatment induced a significant increase in plasma prolactin levels and pituitary weight. PN 200-110 administered to normal rats did not modify these parameters, whereas it reduced the effects of the 15 days estradiol treatment on prolactin levels (53.1 ± 4.9 vs 95.0 ±9.1 μg/l, p<0.0001) and pituitary weight (19.9 ± 0.4 vs 23.0 ± 0.6 mg, p <0.001), to values statistically comparable to those measured after 8 days of estradiol treatment. PN 200-110 alone did not induce any change in protein kinase C activity as compared with controls. In contrast, PN 200-110 treatment significantly counteracted the large increase in soluble activity and the decrease in the particulate one induced by estradiol between day 8 and day 15. We conclude that PN 200-110 opposed the stimulatory effects of chronic in vivo estradiol treatment on plasma prolactin levels and pituitary weight and that this regulation was related to a concomitant modulation of the protein kinase C activity.

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