Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients

1993 ◽  
Vol 86 (1) ◽  
pp. 55-64 ◽  
Author(s):  
Kuninobu Nihei ◽  
Ann C. McKee ◽  
Neil W. Kowall
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Cortex ◽  
Neuronal Degeneration ◽  
Lateral Sclerosis

Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients

Cytotherapy ◽  
2009 ◽  
Vol 11 (1) ◽  
pp. 26-34 ◽  
Author(s):  
Hector R. Martinez ◽  
Maria T. Gonzalez-Garza ◽  
Jorge E. Moreno-Cuevas ◽  
Enrique Caro ◽  
Eugenio Gutierrez-Jimenez ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Motor Cortex ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Lateral Sclerosis

Long-term survival in amyotrophic lateral sclerosis after stem cell transplantation into the frontal motor cortex

Cytotherapy ◽  
2016 ◽  
Vol 18 (6) ◽  
pp. 806-808 ◽  
Author(s):  
Héctor R. Martínez ◽  
María Teresa González-Garza ◽  
Jorge Moreno-Cuevas ◽  
César E. Escamilla-Ocañas ◽  
Juan Miguel Tenorio-Pedraza ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Motor Cortex ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Term Survival ◽  
Long Term Survival ◽  
Lateral Sclerosis

scholarly journals First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Agessandro Abrahao ◽  
Ying Meng ◽  
Maheleth Llinas ◽  
Yuexi Huang ◽  
Clement Hamani ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Cortex ◽  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Primary Motor Cortex ◽  
Brain Barrier ◽  
Human Trial ◽  
Blood Brain ◽  
Lateral Sclerosis ◽  
Bbb Opening

Abstract MR-guided focused ultrasound (MRgFUS) is an emerging technology that can accurately and transiently permeabilize the blood-brain barrier (BBB) for targeted drug delivery to the central nervous system. We conducted a single-arm, first-in-human trial to investigate the safety and feasibility of MRgFUS-induced BBB opening in eloquent primary motor cortex in four volunteers with amyotrophic lateral sclerosis (ALS). Here, we show successful BBB opening using MRgFUS as demonstrated by gadolinium leakage at the target site immediately after sonication in all subjects, which normalized 24 hours later. The procedure was well-tolerated with no serious clinical, radiologic or electroencephalographic adverse events. This study demonstrates that non-invasive BBB permeabilization over the motor cortex using MRgFUS is safe, feasible, and reversible in ALS subjects. In future, MRgFUS can be coupled with promising therapeutics providing a targeted delivery platform in ALS.

Motor cortex abnormalities in amyotrophic lateral sclerosis with transcranial direct-current stimulation

2007 ◽  
Vol 35 (5) ◽  
pp. 620-624 ◽  
Author(s):  
Angelo Quartarone ◽  
Nicolas Lang ◽  
Vincenzo Rizzo ◽  
Sergio Bagnato ◽  
Francesca Morgante ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation ◽  
Lateral Sclerosis

scholarly journals Transcranial direct current stimulation does not modulate motor cortex excitability in patients with amyotrophic lateral sclerosis

2011 ◽  
Vol 44 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Moniek A.M. Munneke ◽  
Dick F. Stegeman ◽  
Yvonne A. Hengeveld ◽  
Jan J. Rongen ◽  
H. Jurgen Schelhaas ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation ◽  
Motor Cortex Excitability ◽  
Lateral Sclerosis

scholarly journals The Axon Guidance Protein Semaphorin 3A Is Increased in the Motor Cortex of Patients With Amyotrophic Lateral Sclerosis

2016 ◽  
Vol 75 (4) ◽  
pp. 326-333 ◽  
Author(s):  
Sonja Körner ◽  
Sebastian Böselt ◽  
Klaudia Wichmann ◽  
Nadine Thau-Habermann ◽  
Antonia Zapf ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Cortex ◽  
Axon Guidance ◽  
Semaphorin 3A ◽  
Lateral Sclerosis
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