Avascular necrosis of bone in neuroblastoma treated with combination chemotherapy

1984 ◽  
Vol 143 (2) ◽  
pp. 152-153 ◽  
Author(s):  
Eiichi Ishii ◽  
Nobuyuki Yoshida ◽  
Sumio Miyazaki
Keyword(s):  
Avascular Necrosis ◽  
Combination Chemotherapy ◽  
Avascular Necrosis Of Bone

scholarly journals Avascular necrosis of bone caused by combination chemotherapy without corticosteroids.

BMJ ◽  
1984 ◽  
Vol 288 (6413) ◽  
pp. 267-268 ◽  
Author(s):  
P G Harper ◽  
C Trask ◽  
R L Souhami
Keyword(s):  
Avascular Necrosis ◽  
Combination Chemotherapy ◽  
Avascular Necrosis Of Bone

Avascular Necrosis of Bone following Revascularization of the Thumb

1979 ◽  
Vol 3 (1) ◽  
pp. 77-87 ◽  
Author(s):  
Charles F.T. Snelling ◽  
Philip M. Hendel
Keyword(s):  
Avascular Necrosis ◽  
Avascular Necrosis Of Bone

Avascular necrosis of bone in bone marrow transplant patients

1989 ◽  
Vol 17 (2) ◽  
pp. 140-143 ◽  
Author(s):  
J. A. Russell ◽  
W. B. Blahey ◽  
T. A. Stuart ◽  
G. Edwards ◽  
R. T. Card
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplant ◽  
Avascular Necrosis ◽  
Marrow Transplant ◽  
Transplant Patients ◽  
Avascular Necrosis Of Bone

scholarly journals Avascular necrosis of bone in childhood cancer patients: a possible role of genetic susceptibility

2015 ◽  
Vol 116 (05) ◽  
pp. 289-295
Author(s):  
L. Geczova ◽  
A. Soltysova ◽  
J. Gecz ◽  
S. Sufliarska ◽  
J. Horakova ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Genetic Susceptibility ◽  
Cancer Patients ◽  
Avascular Necrosis ◽  
Avascular Necrosis Of Bone

scholarly journals P0897RISK FACTORS FOR AVASCULAR BONE NECROSIS IN PATIENTS WITH LUPUS NEPHRITIS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Daniela Monova ◽  
Simeon Monov ◽  
Assen Kamenov ◽  
Vladislava Milenova
Keyword(s):  
Risk Factors ◽  
Lupus Nephritis ◽  
Avascular Necrosis ◽  
Immunosuppressive Agents ◽  
Individual Risk ◽  
Control Group ◽  
High Dose ◽  
Increased Risk ◽  
Avascular Necrosis Of Bone ◽  
Class Iv

Abstract Background and Aims Avascular necrosis of bone (AVN) is an important complication of systemic lupus erythematosus (SLE) and often causes serious physical disability. The aim of this study was to investigate the risk factors for symptomatic avascular necrosis of bone (AVN) in lupus nephritis (LN) patients. Method The records of 374 patients (43 males, 331 females) with kidney biopsy-proven LN were reviewed retrospectively. Symptomatic AVN cases were defined as those with at least one diagnosis of AVN. The patients with LN who did not have AVN were evaluated as a control group. To determine risk factors for AVN, clinical, laboratory and therapeutic variables were analyzed by logistic regression. Results Symptomatic AVN was present in 17 patients (4 males, 13 females, mean age of 27,4±6,7 years). Among the 17 patients, 28 joints presented AVN. 12 occurred in hips (2 bilateral), 6-in ankles, 4-in knees, 3-in shoulders and 1- in lumbar spine. In 9 patients AVN involved 2 or more joints. 14 patients were on steroids at the time of presentation of AVN. 2 patients were not on CS and 1 patient did not has documentation of steroid use. Meta-analysis demonstrates a significant increased risk of AVN in patients with high disease activity and class IV LN (p<0,005). LN patients with AVN showed an earlier onset age (p<0,05) and received significantly higher total cumulative corticosteroid dose. AVN was not significantly associated with use of immunosuppressive agents. Serositis, coagulation disorders, vasculitis, cigarette smoking were higher incidence in male with LN and AVN. Raynaud‘s phenomenon, autoimmune thyroiditis, arthritis, Sjögren’s syndrome, IgM anticardiolipin antibodies, antiphospholipid syndrome, Cushingoid body habitus were higher incidence in female with LN and AVN. Conclusion Many risk factors have been involved in the development of AVN in LN patients. AVN is prevalent in class IV LN and in younger patients. Since asymptomatic osteonecrosis may remain undetected, its true prevalence could be much higher than we reported. Multifocal lesions involving more than three anatomical sites are unusual. Corticosteroids are the principal risk factor, although some cases of AVN occur in relatively steroid naïve patients. Early detection of AVN is important because the prognosis depends of the stage and location of the lesion. An individual risk assessment for AVN development should be made prior to and during treatment for LN, especially in patients high dose corticosteroids.

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