Argininosuccinic aciduria: Metabolic studies and effects of treatment with keto-analogues of essential amino acids

1978 ◽  
Vol 128 (4) ◽  
pp. 225-233 ◽  
Author(s):  
H. B�hles ◽  
H. Heid ◽  
D. Harms ◽  
D. Schmid ◽  
W. Fekl
Keyword(s):  
Amino Acids ◽  
Essential Amino Acids ◽  
Metabolic Studies ◽  
Argininosuccinic Aciduria ◽  
Keto Analogues

Treatment of argininosuccinic aciduria with keto analogues of essential amino acids

1978 ◽  
Vol 31 (10) ◽  
pp. 1808-1811 ◽  
Author(s):  
H Böhles ◽  
D Harms ◽  
H Heid ◽  
D Schmid ◽  
W Fekl
Keyword(s):  
Amino Acids ◽  
Essential Amino Acids ◽  
Argininosuccinic Aciduria ◽  
Keto Analogues

Neonatal citrullinemia: Treatment with keto-analogues of essential amino acids

1977 ◽  
Vol 90 (2) ◽  
pp. 218-224 ◽  
Author(s):  
J. Thoene ◽  
M. Batshaw ◽  
E. Spector ◽  
S. Kulovich ◽  
S. Brusilow ◽  
...  
Keyword(s):  
Amino Acids ◽  
Essential Amino Acids ◽  
Keto Analogues

THE WEIGHT-DEPRESSING ACTION OF α-METHYL-DL-TRYPTOPHAN IN THE RAT

1962 ◽  
Vol 40 (1) ◽  
pp. 739-747 ◽  
Author(s):  
I. Sankoff ◽  
T. L. Sourkes
Keyword(s):  
Amino Acids ◽  
Body Weight ◽  
Glyoxylic Acid ◽  
Essential Amino Acids ◽  
Enzymic Activity ◽  
B Vitamins ◽  
Metabolic Studies ◽  
Comparable Effect ◽  
Acid Reaction ◽  
Tryptophan Pyrrolase

α-Methyl-DL-tryptophan, injected intraperitoneally into rats, has a weight-depressing action lasting up to 72 hours. Dosages in the range 0.015–2.0 millimoles/kg body weight (3.3–436 mg/kg) are effective. Attempts to antagonize the weight-depressing action by giving essential amino acids and B vitamins were unsuccessful. Metabolic studies have shown that about half the injected dose of the compound (or its derivatives), as measured by the Hopkins–Cole glyoxylic acid reaction, is excreted in the urine in 24 hours; most of this appears during the first 4 hours after the injection. Ina search for an explanation for the weight-depressing action of α-methyltryptophan, tryptophan pyrrolase activity in the liver was estimated. This enzymic activity increases for 8 hours after the injection of α-methyltryptophan, and thereafter remains high for 72 hours. Tryptophan-injected animals showed increases in tryptophan pyrrolase level for 1.5 hours, and a return to normal concentrations within 24 hours. Other α-methyl amino acids which were tested had no comparable effect on body weight.

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