Correlation between serum antibody-levels against group B streptococci and gestational age in newborns

1984 ◽  
Vol 142 (2) ◽  
pp. 86-88 ◽  
Author(s):  
K. K. Christensen ◽  
P. Christensen ◽  
G. Duc ◽  
P. H�ger ◽  
C. Kind ◽  
...  
Keyword(s):  
Gestational Age ◽  
Serum Antibody ◽  
Group B Streptococci ◽  
Group B ◽  
Antibody Levels

Intravenous administration of human IgG to newborn infants: changes in serum antibody levels to group B streptococci

1984 ◽  
Vol 143 (2) ◽  
pp. 123-127 ◽  
Author(s):  
K. K. Christensen ◽  
P. Christensen ◽  
H. U. Bucher ◽  
G. Duc ◽  
C. H. Kind ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Serum Antibody ◽  
Newborn Infants ◽  
Group B Streptococci ◽  
Human Igg ◽  
Group B ◽  
Antibody Levels

Colonization With Group B Streptococci in Girls Under 16 Years of Age

PEDIATRICS ◽  
1977 ◽  
Vol 60 (4) ◽  
pp. 473-476 ◽  
Author(s):  
Margaret R. Hammerschlag ◽  
Carol J. Baker ◽  
Susan Alpert ◽  
Dennis L. Kasper ◽  
Ingrid Rosner ◽  
...  
Keyword(s):  
Anal Canal ◽  
Serum Antibody ◽  
Group B Streptococcus ◽  
Group B Streptococci ◽  
Capsular Antigen ◽  
Type Iii ◽  
Group B

Cultures from the vagina, pharynx, and anal canal of 100 healthy girls, 2 months through 15 years of age, were examined for the presence of group B streptococci. Of the 100 participants, 20% were colonized at one or more of these three sites. Pharyngeal colonization was detected in 15% of the girls under 11 years of age and in 5% of those over 11 years of age. Colonization at anogenital sites was observed in 19% of participants under 3 years of age, in 25% of those 11 years of age and older, and in only 4% of those between the ages of 3 and 10 years (P < .025). The concentration of serum antibody directed against the polysaccharide capsular antigen isolated from type III, group B Streptococcus appeared, in part, to be related to increasing age.

scholarly journals Serotypes and Antibody levels of Group B Streptococci in Pregnant Women

2003 ◽  
Vol 77 (3) ◽  
pp. 121-126 ◽  
Author(s):  
Shigemi TERAKUBO ◽  
Yoshitoshi ICHIMAN ◽  
Hiromu TAKEMURA ◽  
Hiroyuki YAMAMOTO ◽  
Jingoro SHIMADA ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Group B Streptococci ◽  
Group B ◽  
Antibody Levels

Role of Antibody to Native Type III Polysaccharide of Group B Streptococcus in Infant Infection

PEDIATRICS ◽  
1981 ◽  
Vol 68 (4) ◽  
pp. 544-549 ◽  
Author(s):  
Carol J. Baker ◽  
Morven S. Edwards ◽  
Dennis L. Kasper
Keyword(s):  
Group B Streptococcus ◽  
Systemic Infection ◽  
Group B Streptococci ◽  
Symptomatic Infection ◽  
Type Iii ◽  
Vaginal Colonization ◽  
Low Levels ◽  
Group B ◽  
Antibody Levels

The role of maternally acquired antibody to native type III polysacchande of group B Streptococcus as a determinant of susceptibility for infant systemic infection was investigated. Sera from 11 1 acutely ill infants with type III group B streptococcal bacteremia and/or meningitis and their mothers, and cord sera from 45 healthy neonates and their mothers who had type III group B streptococcal vaginal colonization at delivery were studied. Sera from each of 111 acutely ill infants contained very low levels ofantibody (sjlt 1.7 µg/ml, median 0.4 µg/ml), and a significant correlation with maternal levels was tested for early onset infection (median 0.6 µg/ml; r = .76; P sjlt .01). Women whose infants remained well had antibody levels sjgt 2 µg/ml in their sera (73%) more often than those whose infants developed symptomatic infection (17%) (P sjlt .001), and the median level in their sera (12.6 µg/ml) was considerably higher. Study of sera obtained during convalescence from 86 surviving infants indicated a poor antibody response to infection. In contrast, high levels of antibody were detected in sera from each of five convalescent women with postpartum bacteremia. These data extend earlier observations suggesting the correlation between low levels of type-specific antibody in serum and risk for systemic infection with type III strains of group B streptococci.

Quantitation of Serum Antibodies to Surface Antigens of Group B Streptococci Types Ia, Ib, and III: Low Antibody Levels in Mothers of Neonatally Infected Infants

1980 ◽  
Vol 12 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Karen Kvist Christensen ◽  
Poul Christensen ◽  
Kerstin Dahlander ◽  
Gerd Faxelius ◽  
Bengt Jacobson ◽  
...  
Keyword(s):  
Surface Antigens ◽  
Serum Antibodies ◽  
Group B Streptococci ◽  
Group B ◽  
Antibody Levels

scholarly journals Protection against group B meningococcal disease. III. Immunogenicity of serotype 2 vaccines and specificity of protection in a guinea pig model.

1978 ◽  
Vol 147 (3) ◽  
pp. 629-644 ◽  
Author(s):  
C E Frasch ◽  
J D Robbins
Keyword(s):  
Guinea Pigs ◽  
Serum Antibody ◽  
Effective Dosage ◽  
Protective Effects ◽  
Immunization Schedule ◽  
Wide Range ◽  
Group B ◽  
Guinea Pig Model ◽  
Antibody Levels

Protein vaccines were prepared from the serotype antigen of group B Neisseria meningitidis strain M986. The detergents Triton X-100, Emulphogene BC-720, and deoxycholate were used to removed the toxic lipopolysaccharide (LPS) portion of the serotype antigen. The LPS was most preferentially solubilized by Emulphogene. Guinea pigs were immunized with one or two doses of vaccine given intramuscularly without adjuvants and the antibody response quantitated by an enzyme-linked immunosorbant assay. Immunization with graded doses of vaccine between 25 to 200 microgram protein indicated a wide range of effective dosage and that a two-dose immunization schedule was superior to a single immunization. The vaccines elicited peak mean serum antibody levels of approximately 30 microgram/ml with bactericidal titers of 1:1,600-1:6,400. The peak antibody levels occurred 5-6 wk after immunization and persisted above preimmune levels for several months. To evaluate the protective effects of immunization, stainless steel springs were implanted subcutaneously into the guinea pigs. The resulting chambers, in unimmunized animals, could be infected with less than 100 type 2 organisms. A single 25-50 microgram dose of vaccine protected 50% of animals from challenge by 5 X 10(5) type 2 meningococci, and as little as 1 microgram vaccine significantly reduced the severity of infection. A two-dose immunization schedule was best and provided nearly complete protection for at least 4 mo against type 2 strains of meningococcal groups B, C, and Y.

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