A new defect of neutrophil chemotaxis and random motility in a child with recurrent bacterial infections and hyperimmunoglobulinemia E

1978 ◽  
Vol 127 (3) ◽  
pp. 173-179 ◽  
Author(s):  
M. Gahr ◽  
J. Ranti ◽  
W. Schr�ter
Keyword(s):  
Bacterial Infections ◽  
Neutrophil Chemotaxis ◽  
Random Motility ◽  
Hyperimmunoglobulinemia E

DEFECTIVE NEUTROPHIL CHEMOTAXIS AND HYPERIMMUNOGLOBULINEMIA E—A REVERSIBLE DEFECT?

1976 ◽  
Vol 65 (4) ◽  
pp. 509-511 ◽  
Author(s):  
G. FONTAN ◽  
F. LORENTE ◽  
M. C. GARCIA RODRIGUEZ ◽  
J. A. OJEDA
Keyword(s):  
Neutrophil Chemotaxis ◽  
Reversible Defect ◽  
Hyperimmunoglobulinemia E

scholarly journals Local Generation of Kynurenines Mediates Inhibition of Neutrophil Chemotaxis by Uropathogenic Escherichia coli

2016 ◽  
Vol 84 (4) ◽  
pp. 1176-1183 ◽  
Author(s):  
Jennifer A. Loughman ◽  
Melanie L. Yarbrough ◽  
Kristin M. Tiemann ◽  
David A. Hunstad
Keyword(s):  
Escherichia Coli ◽  
Polymorphonuclear Leukocytes ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Neutrophil Migration ◽  
Neutrophil Chemotaxis ◽  
Content Type ◽  
Host Immune Responses ◽  
Aryl Hydrocarbon ◽  
Local Generation

During epithelial infections, pathogenic bacteria employ an array of strategies to attenuate and evade host immune responses, including the influx of polymorphonuclear leukocytes (PMN; neutrophils). Among the most common bacterial infections in humans are those of the urinary tract, caused chiefly by uropathogenicEscherichia coli(UPEC). During the establishment of bacterial cystitis, UPEC suppresses innate responses via multiple independent strategies. We recently described UPEC attenuation of PMN trafficking to the urinary bladder through pathogen-specific local induction of indoleamine 2,3-dioxygenase (IDO), a tryptophan catabolic enzyme previously shown to have regulatory activity only in adaptive immunity. Here, we investigated the mechanism by which IDO induction attenuates PMN migration. Local tryptophan limitation, by which IDO is known to influence T cell longevity and proliferation, was not involved in its effect on PMN trafficking. Instead, metabolites in the IDO pathway, particularlyl-kynurenine, directly suppressed PMN transepithelial migration and induced an attached, spread morphology in PMN both at rest and in the presence of chemotactic stimuli. Finally, kynurenines represent known ligands of the mammalian aryl hydrocarbon receptor (AHR), and UPEC infection ofAhr−/−mice recapitulated the derepressed PMN recruitment observed previously inIdo1−/−mice. UPEC therefore suppresses neutrophil migration early in bacterial cystitis by eliciting an IDO-mediated increase in local production of kynurenines, which act through the AHR to impair neutrophil chemotaxis.

scholarly journals Defective neutrophil chemotaxis and raised serum ige levels in a child with recurrent bacterial infections and eczema. Influence of levamisole.

1978 ◽  
Vol 53 (2) ◽  
pp. 144-149 ◽  
Author(s):  
J De Cree ◽  
L Emmery ◽  
J Timmermans ◽  
R Eeckels ◽  
W De Cock ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Neutrophil Chemotaxis ◽  
Serum Ige

Defective neutrophil chemotaxis with variant ichthyosis, hyperimmunoglobulinemia E, and recurrent infections

1975 ◽  
Vol 87 (6) ◽  
pp. 908-911 ◽  
Author(s):  
Stephanie H. Pincus ◽  
I. Talfryn Thomas ◽  
Robert A. Clark ◽  
Hans D. Ochs
Keyword(s):  
Neutrophil Chemotaxis ◽  
Recurrent Infections ◽  
Hyperimmunoglobulinemia E
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