Effects of selective D-1 and D-2 dopamine antagonists on development of methamphetamine-induced behavioral sensitization

1989 ◽  
Vol 98 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Hiroshi Ujike ◽  
Taichi Onoue ◽  
Kazufumi Akiyama ◽  
Takashi Hamamura ◽  
Saburo Otsuki
Keyword(s):  
Behavioral Sensitization ◽  
Dopamine Antagonists

scholarly journals Effects of selective D1 and D2 dopamine antagonists on the development of behavioral sensitization to apomorphine

1991 ◽  
Vol 105 (4) ◽  
pp. 501-507 ◽  
Author(s):  
Bruce A. Mattingly ◽  
James K. Rowlett ◽  
Jamison T. Graff ◽  
Billie Jo Hatton
Keyword(s):  
Behavioral Sensitization ◽  
Dopamine Antagonists

Amisulpride: A New Drug for Management of Postoperative Nausea and Vomiting

2021 ◽  
pp. 106002802098701
Author(s):  
Stacy L. Haber ◽  
April Graybill ◽  
Ani Minasian
Keyword(s):  
Postoperative Nausea ◽  
Data Extraction ◽  
Postoperative Nausea And Vomiting ◽  
Abdominal Distension ◽  
Complete Response ◽  
Nausea And Vomiting ◽  
Dopamine Antagonists ◽  
Dopamine Antagonist ◽  
Additional Information ◽  
Pubmed Search

Objective: To review the pharmacology, efficacy, and safety of amisulpride and determine its role in the management of postoperative nausea and vomiting (PONV). Data Sources: A PubMed search (1946 to November 2020) using the terms amisulpride and APD421 was conducted. Study Selection and Data Extraction: Relevant reports on intravenous amisulpride were included. Data Synthesis: Six clinical trials were evaluated. In 4 trials on the prevention of PONV, a greater percentage of patients who received amisulpride 5 mg compared with placebo experienced a complete response (44%-60% vs 31%-33%, respectively, when used as monotherapy; 58% vs 47%, respectively, when used in combination with another antiemetic). In 2 trials on the treatment of PONV, a significantly greater percentage of patients who received amisulpride 10 mg compared with placebo experienced a complete response (31.4% vs 21.5%, respectively, in patients who had not received prophylaxis; 41.7% vs 28.5%, respectively, in patients who had received prophylaxis). Adverse effects included infusion site pain, chills, hypokalemia, procedural hypotension, and abdominal distension. Relevance to Patient Care and Clinical Practice: Amisulpride is effective for the management of PONV and may be less likely to cause QT prolongation and extrapyramidal symptoms than other dopamine antagonists. Additional information is needed on its use for chemotherapy-induced nausea and vomiting and in children. Conclusions: Amisulpride is an important new option for the multimodal management of PONV in adults, and it may be the preferred dopamine antagonist because of the more favorable safety profile that results from its unique pharmacological properties.

Effect of synthetic GnRH analogues and dopamine antagonists on the maturation of Pacific mullet, Mugil so-iuy Bas.

1994 ◽  
Vol 25 (4) ◽  
pp. 419-425 ◽  
Author(s):  
A. I. GLABOKOV ◽  
J. KOURIL ◽  
E. V. MIKODINA ◽  
T. BARTH
Keyword(s):  
Dopamine Antagonists ◽  
Gnrh Analogues

scholarly journals A rare pediatric case of cluster headaches after cardiac catheterization in a patient with an isolated innominate artery

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110236
Author(s):  
Kimberley Yu ◽  
Madeline Chadehumbe
Keyword(s):  
Aortic Arch ◽  
Cardiac Catheterization ◽  
Innominate Artery ◽  
Dopamine Antagonists ◽  
Autonomic Tone ◽  
Pediatric Case ◽  
Cluster Headaches ◽  
Insight Into ◽  
Secondary Causes ◽  
Isolated Innominate Artery

While cluster headaches are classified and considered a primary headache disorder, secondary causes of cluster headaches have been reported and may provide insight into cluster headaches’ potential pathophysiology. The mechanisms underlying this headache phenotype are poorly understood, and several theories have been proposed that range from the activation within the posterior hypothalamus to autonomic tone dysfunction. We provide a review of reported cases in the literature describing secondary causes after cardiac procedures. We will present a novel pediatric case report of a 16-year-old boy with an isolated innominate artery who presented with acute new-onset headaches 8 h following cardiac catheterization of the aortic arch with arteriography and left pulmonary artery stent placement. The headaches were characterized by attacks of excruciating pain behind the left eye and jaw associated with ipsilateral photophobia, conjunctival injection, rhinorrhea, with severe agitation and restlessness. These met the International Classification of Headache Disorders-3 criteria for episodic cluster headaches. The headaches failed to respond to non-steroidal anti-inflammatory medications, dopamine antagonists, and steroids. He showed an immediate response to treatment with oxygen. This unique case of cluster headaches following cardiac catheterization in a pediatric patient with an isolated innominate artery may provide new insight into cluster headaches’ pathogenesis. We hypothesize that the cardiac catheterization induced cardiac autonomic changes that contributed to the development of his cluster headaches. The role of aortic arch anomalies and procedures in potential disruption of the autonomic tone and the causation of cluster headaches is an area requiring further study.

scholarly journals Behavioral sensitization induced by methamphetamine causes differential alterations in gene expression and histone acetylation of the prefrontal cortex in rats

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Hui Li ◽  
Jing-An Chen ◽  
Qian-Zhi Ding ◽  
Guan-Yi Lu ◽  
Ning Wu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prefrontal Cortex ◽  
Histone Acetylation ◽  
Differentially Expressed Genes ◽  
Behavioral Sensitization ◽  
Functional Enrichment ◽  
Differentially Expressed ◽  
Adult Rats ◽  
Mrna Microarray ◽  
H3 Acetylation

Abstract Background Methamphetamine (METH) is one of the most widely abused illicit substances worldwide; unfortunately, its addiction mechanism remains unclear. Based on accumulating evidence, changes in gene expression and chromatin modifications might be related to the persistent effects of METH on the brain. In the present study, we took advantage of METH-induced behavioral sensitization as an animal model that reflects some aspects of drug addiction and examined the changes in gene expression and histone acetylation in the prefrontal cortex (PFC) of adult rats. Methods We conducted mRNA microarray and chromatin immunoprecipitation (ChIP) coupled to DNA microarray (ChIP-chip) analyses to screen and identify changes in transcript levels and histone acetylation patterns. Functional enrichment analyses, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, were performed to analyze the differentially expressed genes. We then further identified alterations in ANP32A (acidic leucine-rich nuclear phosphoprotein-32A) and POU3F2 (POU domain, class 3, transcription factor 2) using qPCR and ChIP-PCR assays. Results In the rat model of METH-induced behavioral sensitization, METH challenge caused 275 differentially expressed genes and a number of hyperacetylated genes (821 genes with H3 acetylation and 10 genes with H4 acetylation). Based on mRNA microarray and GO and KEGG enrichment analyses, 24 genes may be involved in METH-induced behavioral sensitization, and 7 genes were confirmed using qPCR. We further examined the alterations in the levels of the ANP32A and POU3F2 transcripts and histone acetylation at different periods of METH-induced behavioral sensitization. H4 hyperacetylation contributed to the increased levels of ANP32A mRNA and H3/H4 hyperacetylation contributed to the increased levels of POU3F2 mRNA induced by METH challenge-induced behavioral sensitization, but not by acute METH exposure. Conclusions The present results revealed alterations in transcription and histone acetylation in the rat PFC by METH exposure and provided evidence that modifications of histone acetylation contributed to the alterations in gene expression caused by METH-induced behavioral sensitization.

MK-801 prevents the development of behavioral sensitization during repeated morphine administration

Synapse ◽  
1994 ◽  
Vol 16 (2) ◽  
pp. 137-147 ◽  
Author(s):  
Michael Jeziorski ◽  
Francis J. White ◽  
Marina E. Wolf
Keyword(s):  
Behavioral Sensitization ◽  
Mk 801 ◽  
Morphine Administration
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