Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis

1986 ◽  
Vol 145 (1-2) ◽  
pp. 143-147 ◽  
Author(s):  
J. M. Wit ◽  
B. Rees-Smith ◽  
F. M. Creagh ◽  
H. W. Bruinse ◽  
D. van der Heide ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Tests ◽  
Thyroid Stimulating Immunoglobulins ◽  
Function Tests ◽  
Neonatal Thyrotoxicosis

The differential diagnostic problems in unilateral euthyroid Graves' ophthalmopathy

1984 ◽  
Vol 106 (4) ◽  
pp. 471-476 ◽  
Author(s):  
Hans Perrild ◽  
Ulla Feldt-Rasmussen ◽  
Karine Bech ◽  
Preben Ahlgren ◽  
Jens Mølholm Hansen
Keyword(s):  
Ct Scan ◽  
Thyroid Function ◽  
Thyroid Autoantibodies ◽  
Thyroid Function Tests ◽  
Trh Test ◽  
Normal Thyroid Function ◽  
Thyroid Stimulating Immunoglobulins ◽  
Function Tests ◽  
Graves Ophthalmopathy ◽  
Suppression Test

Abstract. Nine consecutive patients with unilateral ophthalmopathy with suspected endocrine pathogenesis were investigated with a TRH test, a T3 suppression-test, thyroid autoantibodies and a subsequent computerized tomography (CT)-scan. All patients were clinically and biochemically euthyroid. Seven of 9 patients had a normal TRH test and 6 of 7 had a normal T3 suppression test. Slightly to moderately elevated microsomal and thyroglobulin (determined with radioimmunoassay) autoantibodies were found in 5 of 8 patients and in 1 patient thyroid stimulating immunoglobulins (TSI) were found. Three of the patients had normal thyroid function tests and no detectable thyroid autoantibodies. The subsequent CT-scan revealed that one of these had a maxillary tumour protruding into the orbita. The remaining 8 patients had enlargement of one (3 patients) or more (5 patients) eyemuscles. Two of the 8 patients had bilaterally enlarged eyemuscles, one of which was the patient with positive TSI. The remaining 6 patients had unilateral extraocular muscle enlargement. Thus, 2 of 9 patients had ophthalmopathy without thyroid dysfunction so-called isolated autoimmune ophthalmopathy or Graves' ophthalmopathy. Thyroid function tests seem to be of limited value in the diagnosis between endocrine and non-endocrine eye disease, and we recommend the use of diagnostic imaging (e.g. CT-scan) in patients with unilateral exophthalmus in order to diagnose malignant processes.

In a bind: abnormal thyroid function tests

2019 ◽  
Author(s):  
Catriona Hilton ◽  
Farhan Ahmed ◽  
Asif Ali
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Tests ◽  
Function Tests

scholarly journals Falsely diagnosed thyrotoxicosis caused by anti-streptavidin antibodies and pre-wash procedures

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Takuya Ishikawa ◽  
Hiroyuki Sakai ◽  
Tokutaro Itaya ◽  
Suwanai Hirotsugu ◽  
Jumpei Shikuma ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Magnetic Particle ◽  
Thyroid Function Tests ◽  
Case Presentation ◽  
Analytical Interference ◽  
Function Tests ◽  
Inappropriate Treatment ◽  
Published Report ◽  
Old Japanese ◽  
Polyethylene Glycol Precipitation

Abstract Background Anti-streptavidin antibodies are causal determinants of analytical interference during Thyroid function tests, and numerous reports have detailed such interference, with anti-streptavidin antibodies attracting attention. Case presentation We conducted a straightforward investigation of interference due to anti-streptavidin antibodies, with a case of a 60-year-old Japanese man who consulted our department for inconsistencies between his clinical course and Thyroid function tests. Experiments were conducted using Cobas8000 e602, which employs assay procedures with pre-wash to evaluate FT4 and FT3 levels. Conclusions To our knowledge, this is the first published report to clearly investigate such interferences using a combination of polyethylene glycol precipitation, heterophilic blocking tube precipitation, streptavidin-coated magnetic particle precipitation, and different instruments with or without pre-wash. Clinicians should consider that interferences caused by anti-streptavidin antibodies could lead to a misdiagnosis of thyrotoxicosis. Moreover, discussions between laboratory specialists, clinicians, and manufacturers are required to identify interferences and avoid unnecessary examinations and inappropriate treatment.

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