DiGeorge syndrome with hypogammaglobulinaemia: a patient with excess suppressor T cell activity treated with fetal thymus transplantation

1989 ◽  
Vol 148 (6) ◽  
pp. 518-522 ◽  
Author(s):  
M. Mayumi ◽  
H. Kimata ◽  
Y. Suchiro ◽  
S. Hosoi ◽  
S. Ito ◽  
...  
Keyword(s):  
T Cell ◽  
Digeorge Syndrome ◽  
Cell Activity ◽  
Fetal Thymus ◽  
Suppressor T Cell ◽  
Thymus Transplantation

Suppressor T cell activity in lymphoid interstitial pneumonia

1987 ◽  
Vol 34 (1) ◽  
pp. 61-63
Author(s):  
James A. Majeski ◽  
J. Dwight Stinnett ◽  
Deborah J. Cameron
Keyword(s):  
T Cell ◽  
Interstitial Pneumonia ◽  
Cell Activity ◽  
Suppressor T Cell

scholarly journals Suppressor T cell activity and antibodies to alcohol altered hepatocytes.

1984 ◽  
Vol 37 (5) ◽  
pp. 598-598 ◽  
Author(s):  
F Pons Romero ◽  
S Echevarria ◽  
C Rodriguez de Lope ◽  
G San Miguel
Keyword(s):  
T Cell ◽  
Cell Activity ◽  
Suppressor T Cell

scholarly journals Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. II. Selective inactivation of hapten-reactive suppressor T cells by hapten-nonimmunogenic copolymers of D-amino acids, and its application to the study of suppressor T-cell effect on helper T-cell development

1977 ◽  
Vol 146 (1) ◽  
pp. 91-106 ◽  
Author(s):  
T Hamaoka ◽  
M Yoshizawa ◽  
H Yamamoto ◽  
M Kuroki ◽  
M Kitagawa
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Lymphocytes ◽  
T Cell Development ◽  
Cell Activity ◽  
Helper T Cells ◽  
Suppressor T Cells ◽  
Helper T Cell ◽  
Suppressor T Cell ◽  
Suppressor T Lymphocytes

An experimental condition was established in vivo for selectively eliminating hapten-reactive suppressor T-cell activity generated in mice primed with a para-azobenzoate (PAB)-mouse gamma globulin (MGG)-conjugate and treated with PAB-nonimmunogenic copolymer of D-amino acids (D- glutamic acid and D-lysine; D-GL). The elimination of suppressor T-cell activity with PAB-D-GL treatment from the mixed populations of hapten- reactive suppressor and helper T cells substantially increased apparent helper T-cell activity. Moreover, the inhibition of PAB-reactive suppressor T-cell generation by the pretreatment with PAB-D-GL before the PAB-MGG-priming increased the development of PAB-reactive helper T-cell activity. The analysis of hapten-specificity of helper T cells revealed that the reactivity of helper cells developed in the absence of suppressor T cells was more specific for primed PAB-determinants and their cross-reactivities to structurally related determinants such as meta-azobenzoate (MAB) significantly decreased, as compared with the helper T-cell population developed in the presence of suppressor T lymphocytes. In addition, those helper T cells generated in the absence of suppressor T cells were highly susceptible to tolerogenesis by PAB-D- GL. Similarly, the elimination of suppressor T lymphocytes also enhanced helper T-cell activity in a polyclonal fashion in the T-T cell interactions between benzylpenicilloyl (BPO)-reactive T cells and PAB- reactive T cells after immunization of mice with BPO-MGG-PAB. Thus inhibition of BPO-reactive suppressor T-cell development by the BPO-v-GL- pretreatment resulted in augmented generation of PAB-reactive helper T cells with higher susceptibility of tolerogenesis to PAB-D-GL. Thus, these results support the notion that suppressor T cells eventually suppress helper T-cell activity and indicate that the function of suppressor T cells related to helper T-cell development is to inhibit the increase in the specificity and apparent affinity of helper T cells in the primary immune response. The hapten-reactive suppressor and helper T lymphocytes are considered as a model system of T cells that regulate the immune response, and the potential applicability of this system to manipulating various T cell-mediated immune responses is discussed in this context.

scholarly journals Inactivation of suppressor T cell activity by the nontoxic lipopolysaccharide of Rhodopseudomonas sphaeroides.

1990 ◽  
Vol 58 (9) ◽  
pp. 2862-2868 ◽  
Author(s):  
P J Baker ◽  
C E Taylor ◽  
P W Stashak ◽  
M B Fauntleroy ◽  
K Hasløv ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Activity ◽  
Rhodopseudomonas Sphaeroides ◽  
Suppressor T Cell

scholarly journals Loss of suppressor T cells in adult NZB/NZW mice.

1976 ◽  
Vol 144 (3) ◽  
pp. 662-673 ◽  
Author(s):  
R S Krakauer ◽  
T A Waldmann ◽  
W Strober
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Activity ◽  
Suppressor Cell ◽  
Indicator System ◽  
Spleen Cells ◽  
Con A ◽  
Normal Cells ◽  
Suppressor T Cell ◽  
Cell Fractions

We have investigated suppressor T-cell activity in female NZB/NZW F1 mice using PWM-driven IgM biosynthesis in vitro as an indicator system. In initial we studied we observed that spleen cells from normal mice (BALB/c, C57BL/6), as well as from young (4 wk) and adult (18 wk) NZB/NZW mice, cultured in the presence of PWM synthesize 860 +/- 120 ng IgM/10(6) cells/7 days. However, when Con A (at 2 mug/ml) was added directly to the cultures (along with PWM), cells obtained from adult normal mice and young NZB/NZW mice showed a 94% suppression of IgM synthesis, whereas cells obtained from adult NZB/NZW mice were suppressed significantly less. To analyze these findings we studied the effect of Con A-induced suppressor cells (cells cultured with Con A for 24 h and washed free of Con A) on PWM-driven IgM biosynthesis. Spleen cells obtained from normal mice cultured in the presence of Con A-pulsed cells obtained from normal mice and young NZB/NZW mice showed an 83-88% suppression of PWM-driven IgM synthesis. Similarly, supernates obtained from Con A-pulsed cells of normal mice or of young NZB/NZW mice suppressed PWM-driven IgM synthesis. This suppression by Con A-pulsed cells and their supernates required T cells since T-cell fractions but not B-cell fractions eluted from anti-Fab Sephadex columns mediated suppression of co-cultured normal cells; in addition, Con A-pulsed cells treated with anti-theta and complement do not mediate suppression. These studies of Con A-induced suppressor cell activity in normal mice and young NZB/NZW mice contrast with studies of Con A-induced suppressor cell activity in adult NZB/NZW mice. We found that adult NZB/NZW Con A-pulsed cells and supernates obtained from the Con A-pulse cells had vastly decreased suppressor potential; in this case the Con A-pulse cells and supernatant fluids derived from such cells did not suppress PWM-driven IgM synthesis by normal cells. Finally, whereas spleen cells from young and adult NZB/NZW mice differ in their suppressor cell potential, cells from both sources could respond equally to suppressor signals in that Con A-pulsed normal cells or supernates derived from such cells caused equivalent suppression of PWM-driven IgM synthesis by young and adult NZB/NZW cells. These observations allow us to conclude that NZB/NZW mice lose suppressor T-cell activity as they age.

scholarly journals Hypogammaglobulinemia Due to Abnormal Suppressor T-Cell Activity in Crohn's Disease

1984 ◽  
Vol 86 (3) ◽  
pp. 569-576 ◽  
Author(s):  
Charles O. Elson ◽  
Stephen P. James ◽  
Alan S. Graeff ◽  
Robert A. Berendson ◽  
Warren Strober
Keyword(s):  
Crohn’S Disease ◽  
T Cell ◽  
Crohn's Disease ◽  
Cell Activity ◽  
Suppressor T Cell

Failure of immunologic reconstitution in a patient with the DiGeorge syndrome after fetal thymus transplantation

1979 ◽  
Vol 14 (1) ◽  
pp. 96-106 ◽  
Author(s):  
Savita Pahwa ◽  
Rajendra Pahwa ◽  
Genevieve Incefy ◽  
Elena Reece ◽  
Elizabeth Smithwick ◽  
...  
Keyword(s):  
Digeorge Syndrome ◽  
Fetal Thymus ◽  
Thymus Transplantation ◽  
Immunologic Reconstitution

Various Ages Thymus Transplantation Has Differential Ability of Anti Tumor Effects

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 5799-5799
Author(s):  
Yuming Zhang ◽  
Xiaoqing Feng ◽  
Cuiling Wu ◽  
Wenling Guo ◽  
Huiping Li ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Tumor Size ◽  
Allogeneic Bone ◽  
Lymphocyte Function ◽  
Fetal Thymus ◽  
Cell Functions ◽  
Thymus Transplantation ◽  
Thymus Tissue ◽  
Ifn Γ

Abstract [Objective] Our previously work has demonstrated that allogeneic bone marrow transplantation (allo-BMT) combined with thymus transplantation (TT) was effective in restoring donor-derived T cell function and was beneficial for enhancing graft versus tumor (GVT) effects. However, since the thymic cell functions differ with age, the most effective age of thymus should be explored. In the present study, we examined the effects of allo-BMT plus thymus transplantation (TT) from various ages (fetal, newborn, adult) to determine it’s anti tumor effects. [Methods] BALB/c mice (H-2d ) bearing Meth-A sarcoma (H-2d )were treated with allo-BMT combined with or without TT from various age B6 mice(H-2b), the tumor size and survival period of the recipient BALB/c mice were examined, histological studies were performed in the liver, intestine, and the engrafted thymus from the recipients 4 weeks after the BMT. Surface markers on lymphocytes from the spleen were analyzed by 3-color fluorescence staining using a FACScan system to determine chimerism. Cytokine production was examined for monitoring lymphocyte function. [Results]. All mice treated with BMT with or without TT showed fully donor-derived chimerism. The tumor size were significantly smaller in the mice treated with BMT plus TT than those treated with BMT alone. Interestingly, the mice treated with BMT plus newborn or fetal thymus showed the greatest degree of tumor regression. The survival rate in mice treated with BMT plus newborn thymus was significantly prolonged compared with those treated with BMT plus adult thymus or BMT plus fetal thymus. Histologically, both the cortex and medullar areas were clearly shown in each group. Normal T-cell differentiation was also observed in the engrafted thymus. The number of CD4+ T cells significantly increased in the mice treated with BMT plus TT compared with those treated BMT alone. The numbers were highest in the mice treated with BMT plus newborn thymus or BMT plus fetal thymus. Microscopic founding of small intestine and liver indicated no evidence of GVHD in all mice treated with BMT combined with or without TT. The production of IL-2 and IFN-γ was significantly elevated in the mice treated with BMT plus TT compared with those treated with BMT alone. However, the production of IL-2 has no significantly difference in all various age thymus transplantation groups. In contrast, the production of IFN-γ was the highest in the mice treated with BMT plus newborn thymus transplantation. [Conclusion]. The present study indicated that allo-BMT combined with TT induces high thymopoiesis, elicit strong GVT effects, and is effective for the host with cancer. And the combination of allo-BMT with newborn thymus is the most effect. We thus found that donor-derived T cells play an important role in the treatment of leukemia. As human thymus tissue can be obtained from patient with congenital heart disease or from aborted fetuses, so the results of the present study suggest this strategy will become a new way for the treatment of malignant tumors in human. Disclosures No relevant conflicts of interest to declare.

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