Nephrotoxicity of Penicillium aurantiogriseum, a possible factor in the aetiology of Balkan Endemic Nephropathy

1988 ◽  
Vol 102 (1) ◽  
pp. 21-30 ◽  
Author(s):  
S. E. Yeulet ◽  
P. G. Mantle ◽  
M. S. Rudge ◽  
J. B. Greig
Keyword(s):  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy ◽  
Penicillium Aurantiogriseum

Penicillium aurantiogriseum. [Descriptions of Fungi and Bacteria].

1992 ◽  
Author(s):  
Z. Kozakiewicz
Keyword(s):  
Geographical Distribution ◽  
World Wide ◽  
Balkan Endemic Nephropathy ◽  
Tubular Necrosis ◽  
Endemic Nephropathy ◽  
Penicillium Aurantiogriseum ◽  
Renal Tubular ◽  
Renal Tubular Necrosis ◽  
Temperate Climates

Abstract A description is provided for Penicillium aurantiogriseum. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: Found principally on cereals (Pitt & Hocking, 1985). DISEASES: On animals: Penicillium aurantiogriseum produces a nephrotoxin and rats fed with such contaminated feed, or an extracted nephrotoxic fraction, displayed renal tubular necrosis (Adatia et al., 1991). On man: It is implicated in Balkan endemic nephropathy (MacGregor & Mantle, 1991). On insects: It has been isolated from bees (IMI, 1988). GEOGRAPHICAL DISTRIBUTION: World-wide, with a preference for cool to temperate climates.

Is the incidence of Balkan endemic nephropathy decreasing?

2002 ◽  
Vol 50 (1) ◽  
pp. 38-41 ◽  
Author(s):  
P.S. Dimitrov ◽  
V.A. Simeonov ◽  
V.S. Ganev ◽  
W.J.J. Karmaus
Keyword(s):  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy

scholarly journals Balkan endemic nephropathy: Role of ochratoxins A through biomarkers

2006 ◽  
Vol 50 (6) ◽  
pp. 519-529 ◽  
Author(s):  
Marcel Castegnaro ◽  
Delphine Canadas ◽  
Terry Vrabcheva ◽  
Theodora Petkova-Bocharova ◽  
Ivan N. Chernozemsky ◽  
...  
Keyword(s):  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy

E-cadherin expression in upper urothelial carcinoma in Balkan Endemic Nephropathy and non-endemic regions

2009 ◽  
Vol 205 (10) ◽  
pp. 682-689 ◽  
Author(s):  
Ljubinka Jankovic Velickovic ◽  
Takanori Hattori ◽  
Milan Visnjic ◽  
Irena Dimov ◽  
Mariola Stojanovic ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy ◽  
E Cadherin

Balkan endemic nephropathy and associated urothelial cancer

2008 ◽  
Vol 5 (2) ◽  
pp. 105-112 ◽  
Author(s):  
Vladisav Stefanovic ◽  
Zoran Radovanovic
Keyword(s):  
Urothelial Cancer ◽  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy

Global and specific histone acetylation pattern in patients with Balkan endemic nephropathy, a worldwide disease

Renal Failure ◽  
2014 ◽  
Vol 36 (7) ◽  
pp. 1078-1082 ◽  
Author(s):  
Gordana Kocic ◽  
Jovana Cukuranovic ◽  
Tatjana Jevtovic Stoimenov ◽  
Rade Cukuranovic ◽  
Vidosava Djordjevic ◽  
...  
Keyword(s):  
Histone Acetylation ◽  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy ◽  
Acetylation Pattern

scholarly journals Molecular Markers in Upper Urothelial Carcinoma Associated to Balkan Endemic Nephropathy. Aristolochic Acid as the Major Risk Factor of the Worldwide Disease

2009 ◽  
Vol 9 ◽  
pp. 1360-1373 ◽  
Author(s):  
Ljubinka Jankovic Velickovic ◽  
Takanori Hattori ◽  
Vladisav Stefanovic
Keyword(s):  
Regression Analysis ◽  
Urothelial Carcinoma ◽  
Growth Stage ◽  
Aristolochic Acid ◽  
Balkan Endemic Nephropathy ◽  
Specific Cell ◽  
Ki 67 ◽  
High Stage ◽  
Endemic Nephropathy

The role of aristolochic acid in the etiology of Balkan endemic nephropathy (BEN) and associated upper urothelial carcinoma (UUC) was recently confirmed. The aim of this study was to determine the marker(s) specific for BEN-associated UUC. A total of 82 patients with UUC (38 from the BEN region and 44 control tumors) were included in the study. The Ki-67 index in BEN tumors correlated with the grade and multifocality (p< 0.05), but in regression analysis, only the grade of BEN tumor. The p53 index was significantly higher in BEN than in control tumors (p< 0.05), as well as the alteration of p53 (p< 0.05). BEN low-stage tumors, tumors without limphovascular invasion (LVI), and tumors of the renal pelvis had a higher p53 index than the control tumors (p< 0.05, 0.01, 0.05, respectively). The Ki-67 index was higher in control tumors with high-stage and solid growth than in BEN UUC (p < 0.050, 0.005). The Ki-67 correlated with the grade, growth, stage, LVI, and multifocality of UUC on the best way, but not with the group. In regression analysis, only multifocality of UUC had predictive influence on Ki-67 activity (p< 0.001). P53 correlated with the grade, growth, and group (p< 0.05). This investigation identifies the p53 pathway as the specific cell cycle marker involved in BEN-associated UUC.

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