Motor depression and head twitches induced by IP injection of GABA

Antoni Śmiałowski; Maria Śmiałowska; Krystyna Reichenberg; Bożena Byrska; Jerzy Vetulani

doi:10.1007/bf00433099

Motor depression and head twitches induced by IP injection of GABA

Psychopharmacology ◽

10.1007/bf00433099 ◽

1980 ◽

Vol 69 (3) ◽

pp. 295-298 ◽

Cited By ~ 6

Author(s):

Antoni Śmiałowski ◽

Maria Śmiałowska ◽

Krystyna Reichenberg ◽

Bożena Byrska ◽

Jerzy Vetulani

Keyword(s):

Head Twitches

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The mechanism by which the selective 5-HT1A receptor antagonist S-(−)UH 301 produces head-twitches in mice

Pharmacology Biochemistry and Behavior ◽

10.1016/0091-3057(96)00072-x ◽

1996 ◽

Vol 55 (1) ◽

pp. 1-10 ◽

Cited By ~ 17

Author(s):

Nissar A. Darmani ◽

Sharon L. Reeves

Keyword(s):

Receptor Antagonist ◽

Head Twitches

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Potentiation of 5-methoxy-n,n-dimethyltryptamine-induced head-twitches by diazepam: Evidence for involvement of adenosine uptake inhibition

Drug Development Research ◽

10.1002/ddr.430300403 ◽

1993 ◽

Vol 30 (4) ◽

pp. 213-218 ◽

Cited By ~ 1

Author(s):

Paul C. Moser

Keyword(s):

Uptake Inhibition ◽

Head Twitches ◽

Adenosine Uptake

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Intraventricular injections of galanin counteract development of head twitches induced by the 5-HT-2 agonist 1-(2,5-dimethoxyphenyl-4-bromo)-2-aminopropane

Acta Physiologica Scandinavica ◽

10.1111/j.1748-1716.1989.tb08668.x ◽

1989 ◽

Vol 136 (2) ◽

pp. 297-298 ◽

Cited By ~ 11

Author(s):

S.-O. ÖGREN ◽

K. FUXE

Keyword(s):

Head Twitches ◽

Intraventricular Injections

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EFFECTS OF ROLIPRAM OR TRICYCLIC ANTIDEPRESSANT ON HEAD TWITCHES AND SIGNAL TRANSMEMBRANE CONTROL.

Clinical Neuropharmacology ◽

10.1097/00002826-199202001-00847 ◽

1992 ◽

Vol 15 ◽

pp. 436B

Author(s):

H. Ozawa ◽

T. Saito ◽

N. Takahata

Keyword(s):

Tricyclic Antidepressant ◽

Head Twitches

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Neuroleptic-induced reduction of quipazine-elicited head-twitches in rats: Possible involvement of striatal dopaminergic supersensitivity

Pharmacology Biochemistry and Behavior ◽

10.1016/0091-3057(88)90409-1 ◽

1988 ◽

Vol 31 (4) ◽

pp. 941-944 ◽

Cited By ~ 5

Author(s):

Rossella Dall'Olio ◽

Alberto Vaccheri ◽

Ottavio Gandolfi ◽

Paola Roncada ◽

Nicola Montanaro

Keyword(s):

Head Twitches ◽

Dopaminergic Supersensitivity

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Effects of paroxetine on 5-HT-induced head twitches and phosphatidylinositol hydrolysis in mice

Neuroreport ◽

10.1097/00001756-199211000-00016 ◽

1992 ◽

Vol 3 (11) ◽

pp. 1009-1012 ◽

Cited By ~ 2

Author(s):

Elizabeth F. Marshall ◽

Joan Milne ◽

Shirley M. Dodds

Keyword(s):

Head Twitches

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Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New Arylpiperazines

E-Journal of Chemistry ◽

10.1155/2011/346087 ◽

2011 ◽

Vol 8 (3) ◽

pp. 1044-1051

Author(s):

Sushil Kumar ◽

A. K. Wahi ◽

Ranjit Singh

Keyword(s):

Atypical Antipsychotic ◽

Computational Studies ◽

Lead Compound ◽

Physiochemical Properties ◽

Pharmacological Evaluation ◽

Climbing Behavior ◽

Head Twitches ◽

Antipsychotic Activity ◽

Albino Mice ◽

Software Programs

A series of novel arylpiperazines were synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced climbing behavior (D2antagonism), 5-HTP induced head twitches (5-HT2Aantagonism) and catalepsy studies in albino mice. The physicochemical similarity of the target compounds with respect to standard drugs clozapine, ketanserine and risperidone was assessed by calculating from a set of physiochemical properties using software programs. The test compounds(3a-j)demonstrated good similarity values with respect to the standard drugs. Among them, compound3dhas emerged as an important lead compound showing potential atypical antipsychotic like profile.

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