Effect of single oral doses of various neuroleptic drugs on salivary secretion rate, pH, and buffer capacity in healthy subjects

1981 ◽  
Vol 75 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Lars Molander ◽  
Dowen Birkhed
Keyword(s):  
Healthy Subjects ◽  
Buffer Capacity ◽  
Salivary Secretion ◽  
Secretion Rate ◽  
Neuroleptic Drugs ◽  
Oral Doses

Safety and pharmacokinetics of mifentidine after increasing oral doses in healthy subjects

1988 ◽  
Vol 35 (6) ◽  
pp. 673-676
Author(s):  
B. P. Imbimbo ◽  
M. Seiberling ◽  
U. Peuckert ◽  
G. Hoexter ◽  
H. Maier-Lenz ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Oral Doses

scholarly journals Switching to normal diet reverses kwashiorkor-induced salivary impairments via increased nitric oxide level and expression of aquaporin 5 in the submandibular glands of male Wistar rats

2019 ◽  
Vol 44 (4) ◽  
pp. 365-372
Author(s):  
Taye Jemilat Lasisi ◽  
Shehu Tijani Shittu ◽  
Akinola Rasak Alada
Keyword(s):  
Nitric Oxide ◽  
Total Protein ◽  
Immunoglobulin A ◽  
Salivary Secretion ◽  
Normal Diet ◽  
Secretion Rate ◽  
Control Group ◽  
Aquaporin 5 ◽  
Submandibular Glands ◽  
Nitric Oxide Level

Kwashiorkor, a form of malnutrition, has been shown to cause impaired salivary secretion. However, there is dearth of information on the mechanism that underlies this complication. Also, whether returning to normal diet after kwashiorkor will reverse these complications or not is yet to be discerned. Thus, this study aimed at assessing the mechanisms that underlie kwashiorkor-induced salivary impairments and to evaluate the effects of switching back to normal-diet on kwashiorkor-induced salivary impairments. Weaning rats were randomly divided into 3 groups (control group, kwashiorkor group (KG), re-fed kwashiorkor group (RKG)) of 7 rats each. The control group had standard rat chow while the KG and RKG were fed 2% protein diet for 6 weeks to induce kwashiorkor. The RKG had their diet changed to standard rat-chow for another 6 weeks. Blood and stimulated saliva samples were collected for the analysis of total protein, electrolytes, amylase, immunoglobulin A (IgA) secretion rate, leptin, and ghrelin. Tissue total protein, nitric oxide level, expressions of Na+/K+-ATPase, muscarinic (M3) receptor, and aquaporin 5 in the submandibular glands were also determined. Data were presented as means ± SEM and compared using ANOVA with Tukey’s post hoc test. RKG showed improved salivary function evidenced by reduced salivary lag-time and potassium and increased flow rate, sodium, amylase, IgA secretion rate, leptin, submandibular nitric oxide level, and aquaporin 5 expression compared with KG. This study for the first time demonstrated that kwashiorkor caused significant reduction in salivary secretion through reduction of nitric oxide level and aquaporin 5 expression in submandibular salivary glands. Normal-diet re-feeding after kwashiorkor returned salivary secretion to normal.

Tolerance and pilot pharmacokinetics of amiflamine after increasing single oral doses in healthy subjects

1986 ◽  
Vol 40 (1) ◽  
pp. 81-85 ◽  
Author(s):  
G Alván ◽  
C Graffner ◽  
M Grind ◽  
L L Gustafsson ◽  
J E Lindgren ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Oral Doses

Pharmacokinetics of bolus intravenous and oral doses of L-carnitine in healthy subjects

1988 ◽  
Vol 35 (1) ◽  
pp. 69-75 ◽  
Author(s):  
P. Harper ◽  
C. -E. Elwin ◽  
G. Cederblad
Keyword(s):  
Healthy Subjects ◽  
Oral Doses
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