Acute and chronic ethanol administration on specific 3H-GABA binding in different rat brain areas

1980 ◽  
Vol 67 (3) ◽  
pp. 261-264 ◽  
Author(s):  
A. Reggiani ◽  
M. L. Barbaccia ◽  
P. F. Spano ◽  
M. Trabucchi
Keyword(s):  
Rat Brain ◽  
Chronic Ethanol ◽  
Ethanol Administration ◽  
Brain Areas ◽  
Gaba Binding ◽  
Chronic Ethanol Administration

Effect of acute and chronic ethanol administration on serotonin turnover in rat brain

1974 ◽  
Vol 37 (2) ◽  
pp. 91-100 ◽  
Author(s):  
D. Frankel ◽  
J. M. Khanna ◽  
H. Kalant ◽  
A. E. LeBlanc
Keyword(s):  
Rat Brain ◽  
Chronic Ethanol ◽  
Ethanol Administration ◽  
Serotonin Turnover ◽  
Chronic Ethanol Administration

scholarly journals Enhancement of rat brain tryptophan metabolism by chronic ethanol administration and possible involvement of decreased liver tryptophan pyrrolase activity

1979 ◽  
Vol 178 (3) ◽  
pp. 575-580 ◽  
Author(s):  
A A Badawy ◽  
N F Punjani ◽  
M Evans
Keyword(s):  
Methylene Blue ◽  
Rat Brain ◽  
Chronic Ethanol ◽  
Tryptophan Metabolism ◽  
Ethanol Administration ◽  
Chronic Ethanol Administration ◽  
Tryptophan Pyrrolase ◽  
Tryptophan Concentration ◽  
Phenazine Methosulphate ◽  
The Brain

1. Chronic ethanol administration enhances rat brain 5-hydroxytryptamine synthesis by increasing the availability of circulating tryptophan to the brain. This increased availability is not insulin-mediated or lipolysis-dependent. 2. Under these conditions, tryptophan accumulates in the liver and apo-(tryptophan pyrrolase) activity is completely abolished, but could be restored by administration of regenerators of liver NAD+ and/or NADP+. 3. All four regenerators used (fructose, Methylene Blue, phenazine methosulphate and sodium pyruvate) prevented the ethanol-induced increase in liver tryptophan concentration and the increased availability of tryptophan to the brain. 4. It is suggested that the enhancement of brain tryptophan metabolism by chronic ethanol administration is caused by the decreased hepatic tryptophan pyrrolase activity. The results are briefly discussed in relation to previous work with ethanol. 5. Fructose enhances the conversion of tryptophan into 5-hydroxyindol-3-ylacetic acid in brains of ethanol-treated rats, whereas Methylene Blue inhibits this conversion in both control and ethanol-treated animals.

Effects of Chronic Ethanol Administration on Rat Brain Phospholipid Metabolism

1987 ◽  
Vol 48 (3) ◽  
pp. 974-980 ◽  
Author(s):  
Grace Y. Sun ◽  
Hsueh-Meei Huang ◽  
Renuka Chandrasekhar ◽  
Ding Z. Lee ◽  
Albert Y. Sun
Keyword(s):  
Rat Brain ◽  
Phospholipid Metabolism ◽  
Chronic Ethanol ◽  
Ethanol Administration ◽  
Brain Phospholipid ◽  
Chronic Ethanol Administration
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