The effect of chlorpromazine on homovanillic acid levels in cerebrospinal fluid of schizophrenic patients

1974 ◽  
Vol 35 (4) ◽  
pp. 287-294 ◽  
Author(s):  
Bengt Fyr� ◽  
Birgitta Wode-Helgodt ◽  
Stefan Borg ◽  
G�ran Sedvall
Keyword(s):  
Cerebrospinal Fluid ◽  
Homovanillic Acid ◽  
Schizophrenic Patients

Low CSF Concentrations of Cyclic GMP in Schizophrenia

1983 ◽  
Vol 142 (3) ◽  
pp. 288-291 ◽  
Author(s):  
W. F. Gattaz ◽  
H. Cramer ◽  
H. Beckmann
Keyword(s):  
Cerebrospinal Fluid ◽  
Cyclic Gmp ◽  
Homovanillic Acid ◽  
Healthy Controls ◽  
Neuroleptic Treatment ◽  
Cholinergic Activity ◽  
Schizophrenic Patients ◽  
Csf Levels

SummaryIncreasing evidence suggests that the concentrations of cyclic guanosine 3′5′-monophosphate (cGMP) in the cerebrospinal fluid (CSF) may reflect central cholinergic activity. When the concentrations of this nucleotide in the CSF from 28 schizophrenic patients (13 without and 15 with neuroleptic treatment) and 16 psychiatrically healthy controls was determined the schizophrenics showed significantly lower CSF levels of cGMP as compared to controls.As dopamine and homovanillic acid concentrations were not altered in these CSF samples, this finding of reduced cGMP suggests a cholinergic-dopaminergic imbalance in schizophrenia, with a reduction of the former and consequently a relative dominance of the latter.

HOMOVANILLIC ACID IN CEREBROSPINAL FLUID OF SCHIZOPHRENIC PATIENTS BEFORE AND DURING CiHLORPROMAZINE TREATMENT

1973 ◽  
Vol 49 (s243) ◽  
pp. 54-54 ◽  
Author(s):  
BENGT FYRÖ ◽  
BIRGITTA WODE-HELGODT ◽  
STEFAN BORG ◽  
GÖRAN SEDVALL
Keyword(s):  
Cerebrospinal Fluid ◽  
Homovanillic Acid ◽  
Schizophrenic Patients

Changes on recovery in the concentrations of tryptophan and the biogenic amine metabolites in the cerebrospinal fluid of patients with affective illness

1973 ◽  
Vol 3 (3) ◽  
pp. 319-325 ◽  
Author(s):  
G. W. Ashcroft ◽  
Ivy M. Blackburn ◽  
D. Eccleston ◽  
A. I. M. Glen ◽  
W. Hartley ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Homovanillic Acid ◽  
Affective Illness ◽  
Normal Limits ◽  
Low Concentrations ◽  
Depressed Group ◽  
Before And After ◽  
Acid Metabolites ◽  
Bipolar Patients ◽  
Manic Patients

SYNOPSISThe concentration of the acid metabolites of dopamine, and 5-hydroxytryptamine (5-HT), homovanillic acid (HVA), and 5-hydroxyindolacetic acid (5-HIAA) respectively, were estimated in the cerebrospinal fluid of patients suffering from either unipolar or bipolar affective illness, both before and after recovery. Significantly low concentrations of HVA and 5-HIAA (P<0·01 and 0·05 respectively) were found in the unipolar depressed group and these did not return to normal on recovery. Depressed bipolar patients had levels within normal limits. In bipolar manic patients the HVA concentration fell on recovery to a level significantly lower (P<0·05) than controls. There was no difference in the levels of tryptophan in the CSF of any of the groups of patients nor was there any alteration on recovery. There was a high correlation between 5-HIAA and HVA in the same CSF. These findings are against the amine hypothesis which postulated in depression a lowered concentration of transmitter amine at synaptic junction.

DOSE PLASMA HOMOVANILLIC ACID LEVELS CHANGE WHEN SCHIZOPHRENIC PATIENTS GET WORSE?

1992 ◽  
Vol 15 ◽  
pp. 259B
Author(s):  
E. Suzuki ◽  
S. Kanba ◽  
M. Nibuya ◽  
F. Shintani ◽  
N. Kinoshita ◽  
...  
Keyword(s):  
Homovanillic Acid ◽  
Schizophrenic Patients

scholarly journals Reduced Brain Delivery of Homovanillic Acid to Cerebrospinal Fluid During Human Aging

2004 ◽  
Vol 61 (11) ◽  
pp. 1721 ◽  
Author(s):  
Stanley I. Rapoport ◽  
Mark B. Schapiro ◽  
Conrad May
Keyword(s):  
Cerebrospinal Fluid ◽  
Homovanillic Acid ◽  
Brain Delivery ◽  
Human Aging

Influence of renal clearance on peripheral homovanillic acid measurements in healthy subjects and schizophrenic patients

1993 ◽  
Vol 11 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Charles L. Whelton ◽  
Ram N. Gupta ◽  
John M. Cleghorn ◽  
Shannon R. Ballagh
Keyword(s):  
Renal Clearance ◽  
Healthy Subjects ◽  
Homovanillic Acid ◽  
Schizophrenic Patients
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