Cerebrospinal fluid homovanillic acid and hypokinetic side effects of neuroleptics

1985 ◽  
Vol 85 (2) ◽  
pp. 184-186 ◽  
Author(s):  
Malcolm B. Bowers
Keyword(s):  
Cerebrospinal Fluid ◽  
Side Effects ◽  
Homovanillic Acid

Changes on recovery in the concentrations of tryptophan and the biogenic amine metabolites in the cerebrospinal fluid of patients with affective illness

1973 ◽  
Vol 3 (3) ◽  
pp. 319-325 ◽  
Author(s):  
G. W. Ashcroft ◽  
Ivy M. Blackburn ◽  
D. Eccleston ◽  
A. I. M. Glen ◽  
W. Hartley ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Homovanillic Acid ◽  
Affective Illness ◽  
Normal Limits ◽  
Low Concentrations ◽  
Depressed Group ◽  
Before And After ◽  
Acid Metabolites ◽  
Bipolar Patients ◽  
Manic Patients

SYNOPSISThe concentration of the acid metabolites of dopamine, and 5-hydroxytryptamine (5-HT), homovanillic acid (HVA), and 5-hydroxyindolacetic acid (5-HIAA) respectively, were estimated in the cerebrospinal fluid of patients suffering from either unipolar or bipolar affective illness, both before and after recovery. Significantly low concentrations of HVA and 5-HIAA (P<0·01 and 0·05 respectively) were found in the unipolar depressed group and these did not return to normal on recovery. Depressed bipolar patients had levels within normal limits. In bipolar manic patients the HVA concentration fell on recovery to a level significantly lower (P<0·05) than controls. There was no difference in the levels of tryptophan in the CSF of any of the groups of patients nor was there any alteration on recovery. There was a high correlation between 5-HIAA and HVA in the same CSF. These findings are against the amine hypothesis which postulated in depression a lowered concentration of transmitter amine at synaptic junction.

scholarly journals Reduced Brain Delivery of Homovanillic Acid to Cerebrospinal Fluid During Human Aging

2004 ◽  
Vol 61 (11) ◽  
pp. 1721 ◽  
Author(s):  
Stanley I. Rapoport ◽  
Mark B. Schapiro ◽  
Conrad May
Keyword(s):  
Cerebrospinal Fluid ◽  
Homovanillic Acid ◽  
Brain Delivery ◽  
Human Aging

Clomipramine (Anafranil) in the Treatment of Cataplexy

1973 ◽  
Vol 1 (5) ◽  
pp. 427-431 ◽  
Author(s):  
J D Parkes
Keyword(s):  
Side Effects ◽  
Inborn Error ◽  
Homovanillic Acid ◽  
Considerable Increase ◽  
Cerebral Metabolism ◽  
Inborn Error Of Metabolism ◽  
Familial Occurrence ◽  
One Year

Seven patients with narcolepsy and cataplexy were treated with clomipramine. This abolished cataplexy in three patients and resulted in a reduction in the frequency of attacks in the others. Tolerance to clomipramine did not develop and treatment remained effective over a one-year period. One patient had a considerable increase in weight but no other side-effects of clomipramine occurred. Clomipramine had no action on narcolepsy but given together with amphetamines resulted in a reduction in the amphetamine dosage required to control narcolepsy. The life-long nature, familial occurrence and absence of specific pathology in the narcoleptic syndrome is consistent with an inborn error of metabolism. The concentration of homovanillic acid in the CSF of six patients with narcolepsy was approximately half normal. One of these patients had not been treated with amphetamines. This finding could be explained by a reduced cerebral metabolism of catecholamines in the narcoleptic syndrome.

Noradrenergic Overactivity in Chronic Schizophrenia: Evidence Based on Cerebrospinal Fluid Noradrenaline and Cyclic Nucleotide Concentrations

1980 ◽  
Vol 137 (4) ◽  
pp. 346-351 ◽  
Author(s):  
U. C. R. Gomes ◽  
B. C. Shanley ◽  
L. Potgieter ◽  
J. T. Roux
Keyword(s):  
Cerebrospinal Fluid ◽  
Cyclic Nucleotides ◽  
Homovanillic Acid ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Chronic Schizophrenia ◽  
Evidence Based ◽  
Chronic Schizophrenics ◽  
Hydroxyindoleacetic Acid ◽  
Lumbar Cerebrospinal Fluid

SummaryConcentrations of noradrenaline (NA), homovanillic acid, 5-hydroxyindoleacetic acid and cyclic nucleotides were determined in lumbar cerebrospinal fluid (CSF) from acute and chronic schizophrenics and various groups of psychiatric and non-psychiatric control subjects. Statistically significant increases in NA and cyclic adenosine monophosphate were found in CSF from chronic schizophrenics compared to all other groups. These results were shown by statistical analyses to be unrelated to medication. They may be interpreted as evidence for noradrenergic overactivity as a possible primary abnormality in chronic schizophrenia.

Elevated Homovanillic Acid in Cerebrospinal Fluid of Children with Infantile Spasms

Epilepsia ◽  
1980 ◽  
Vol 21 (4) ◽  
pp. 387-392 ◽  
Author(s):  
Masatoshi Ito ◽  
Takehiko Okuno ◽  
Haruki Mikawa ◽  
Yoshitsugu Osumi
Keyword(s):  
Cerebrospinal Fluid ◽  
Homovanillic Acid ◽  
Infantile Spasms
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