Impaired acquisition of an operant response in young rats depleted of brain dopamine in neonatal life

Thomas G. Heffner; Lewis S. Seiden

doi:10.1007/bf00427796

Impaired acquisition of an operant response in young rats depleted of brain dopamine in neonatal life

Psychopharmacology ◽

10.1007/bf00427796 ◽

1983 ◽

Vol 79 (2-3) ◽

pp. 115-119 ◽

Cited By ~ 32

Author(s):

Thomas G. Heffner ◽

Lewis S. Seiden

Keyword(s):

Operant Response ◽

Brain Dopamine ◽

Young Rats ◽

Neonatal Life

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Monocrotophos induced oxidative stress and alterations in brain dopamine and serotonin receptors in young rats

Toxicology and Industrial Health ◽

10.1177/0748233713500834 ◽

2013 ◽

Vol 32 (3) ◽

pp. 422-436 ◽

Cited By ~ 13

Author(s):

Madhu L Sankhwar ◽

Rajesh S Yadav ◽

Rajendra K Shukla ◽

Dhirendra Singh ◽

Reyaz W Ansari ◽

...

Keyword(s):

Oxidative Stress ◽

Serotonin Receptors ◽

Brain Dopamine ◽

Young Rats ◽

Dopamine And Serotonin Receptors

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Extraversion and Dopamine

European Psychologist ◽

10.1027/1016-9040.3.1.37 ◽

1998 ◽

Vol 3 (1) ◽

pp. 37-50 ◽

Cited By ~ 22

Author(s):

Thomas H. Rammsayer

Keyword(s):

Individual Differences ◽

D2 Receptor ◽

D2 Receptors ◽

Behavioral Differences ◽

Biological Mechanisms ◽

Brain Dopamine ◽

Personality Dimension ◽

Time Performance ◽

Reaction Time Performance ◽

Induced Changes

Recent research suggests that individual differences in brain dopamine (DA) functioning may be related to the personality dimension of extraversion. The present study was designed to further elucidate the biological mechanisms underlying behavioral differences between extraverts and introverts. For this purpose, the differential effects of a pharmacologically induced blockade of mesolimbocortical DA D2 receptors on reaction-time performance were investigated in 24 introverted and 24 extraverted subjects. Introverts were found to be much more susceptible to pharmacologically induced changes in D2 receptor activity than extraverts. This finding provides additional experimental evidence for the notion that individual differences in D2 receptor responsivity may represent a neurobiological substratum for the personality dimension of extraversion.

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Repeated isolation stress in the neonatal rat: Relation to brain dopamine systems in the 10-day-old rat.

Behavioral Neuroscience ◽

10.1037/0735-7044.112.6.1466 ◽

1998 ◽

Vol 112 (6) ◽

pp. 1466-1474 ◽

Cited By ~ 41

Author(s):

Priscilla Kehoe ◽

W. J. Shoemaker ◽

C. Arons ◽

L. Triano ◽

G. Suresh

Keyword(s):

Neonatal Rat ◽

Brain Dopamine ◽

Isolation Stress

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Effects of Prenatal Cocaine Exposure on Brain Dopamine Receptor Function, Behavior, and Cocaine Reinforcement in Adult Male and Female Rhesus Monkeys

PsycEXTRA Dataset ◽

10.1037/e654422011-001 ◽

2011 ◽

Author(s):

Michael A. Nader

Keyword(s):

Dopamine Receptor ◽

Adult Male ◽

Rhesus Monkeys ◽

Receptor Function ◽

Cocaine Exposure ◽

Brain Dopamine ◽

Prenatal Cocaine Exposure ◽

Male And Female ◽

Prenatal Cocaine ◽

Female Rhesus

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The importance of CREB phosphorylation by PKA, CaMK and MAPK for olfactory learning in young rats

Neuroscience Research ◽

10.1016/s0168-0102(00)81442-x ◽

2000 ◽

Vol 38 ◽

pp. S99

Author(s):

J Zhang

Keyword(s):

Olfactory Learning ◽

Creb Phosphorylation ◽

Young Rats

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On the Fibrinolytic System in Aged Rats, and Its Reactivity to Endotoxin and Cytokines

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648525 ◽

1992 ◽

Vol 67 (06) ◽

pp. 697-701 ◽

Cited By ~ 6

Author(s):

J J Emeis ◽

A Brouwer ◽

R J Barelds ◽

M A Horan ◽

S K Durham ◽

...

Keyword(s):

Plasminogen Activator ◽

Fibrinolytic Activity ◽

Fibrinolytic System ◽

Tissue Type ◽

High Dose ◽

Base Line ◽

Aged Rats ◽

Tissue Type Plasminogen Activator ◽

Young Rats ◽

Type Plasminogen Activator

SummaryAged rats are more susceptible to endotoxin-induced effects, including microthrombosis and platelet aggregation, than are young rats. To investigate whether changes in the fibrinolytic system might be involved, we investigated the fibrinolytic activity in plasma euglobulin fractions and tissues (lung and heart) of young (6-months old) and aged (24-months old) rats under baseline conditions and after challenge with endotoxin. Aged rats had lower plasma levels of tissue-type plasminogen activator (t-PA) and of urokinase-type PA (u-PA) activity. PA inhibitor (PAI) activity was higher in the plasma of aged rats, as was t-PA activity in lung and heart.Rats were treated with either a low dose (1 μg/kg) or a high dose (10 mg/kg) of endotoxin. Both treatments induced a transient phase of increased blood fibrinolytic activity, as evidenced by higher levels of tissue-type plasminogen activator (t-PA) activity and decreased levels of PA inhibitor (PAI) activity. Over time, the fibrinolytic activity decreased, probably due to increased levels of PA inhibitor.Both the early increase in t-PA activity, and the subsequent increase in PAI activity, were more pronounced in the aged rats, as compared with the younger rats, after the high dose of endotoxin. The aged rats also responded to an injection of interleukin-1β or tumor necrosis factor-α with a larger increase of PAI activity than did the younger rats.Together the data suggest that, compared to young rats, aged rats have a decreased base-line plasma fibrinolytic activity, while their fibrinolytic system is more responsive to challenge by endotoxin and cytokines.

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