Phencyclidine-induced locomotor activity in the rat is blocked by 6-hydroxydopamine lesion of the nucleus accumbens: Comparisons to other psychomotor stimulants

1983 ◽  
Vol 82 (1-2) ◽  
pp. 83-88 ◽  
Author(s):  
Edward D. French ◽  
Guido Vantini
Keyword(s):  
Locomotor Activity ◽  
Nucleus Accumbens ◽  
Psychomotor Stimulants ◽  
6 Hydroxydopamine

scholarly journals Locomotor Activity in Relation to Dopamine and Noradrenaline in the Nucleus accumbens, Septal and Frontal Areas: A 6-Hydroxydopamine Study

1986 ◽  
Vol 16 (1) ◽  
pp. 37-42 ◽  
Author(s):  
R.D. Oades ◽  
K. Taghzouti ◽  
J.-M. Rivet ◽  
H. Simon ◽  
M. Le Moal
Keyword(s):  
Locomotor Activity ◽  
Nucleus Accumbens ◽  
6 Hydroxydopamine

Functional interaction of dopamine and glutamate in the nucleus accumbens in the regulation of locomotion

1993 ◽  
Vol 71 (5-6) ◽  
pp. 407-413 ◽  
Author(s):  
Michael Wu ◽  
Stefan M. Brudzynski ◽  
Gordon J. Mogenson
Keyword(s):  
Locomotor Activity ◽  
Nucleus Accumbens ◽  
Nmda Receptor ◽  
Aspartic Acid ◽  
Receptor Agonist ◽  
Dopamine Neurons ◽  
Mesolimbic Dopamine ◽  
Axon Terminals ◽  
6 Hydroxydopamine ◽  
Dose Dependent

The interaction of dopamine and glutamate in the nucleus accumbens in the regulation of locomotion was investigated. Microinjection of N-methyl-D-aspartic acid (NMDA, a glutamatergic NMDA receptor agonist) or α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA, a quisqualic receptor agonist which is a glutamatergic non-NMDA receptor agonist) into the nucleus accumbens caused a substantial increase in locomotor activity. This increase in locomotor activity was significantly reduced by prior administration of the dopamine D2 agonist quinpirole, but not the D1 agonist, SKF 38393, into the same brain sites. The reduction in locomotion produced by quinpirole was dose dependent. Eight days after the ventral tegmental area was lesioned with 6-hydroxydopamine to destroy the dopamine projection and the axon terminals of the mesolimbic dopamine neurons in nucleus accumbens, the hyperkinetic effects produced by injections of NMDA and AMPA into the nucleus accumbens were substantially reduced. These results suggested that the glutamate agonist induced locomotion is mediated by dopamine. Thus, it appears that NMDA- or AMPA-induced locomotion is due to the activation of glutamate receptors on the mesolimbic dopamine terminals in the nucleus accumbens which release dopamine and subsequently increase locomotion.Key words: nucleus accumbens, dopamine, glutamate, quinpirole, locomotion, N-methyl-D-aspartic acid, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid.

Inhibition of d-amphetamine-induced locomotor activity by injection of haloperidol into the nucleus accumbens of the rat

1975 ◽  
Vol 41 (2) ◽  
pp. 87-95 ◽  
Author(s):  
A. J. J. Pijnenburg ◽  
W. M. M. Honig ◽  
J. M. Van Rossum
Keyword(s):  
Locomotor Activity ◽  
Nucleus Accumbens

scholarly journals Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making

2009 ◽  
Vol 29 (8) ◽  
pp. 1678-1691 ◽  
Author(s):  
Mark E. Walton ◽  
James Groves ◽  
Katie A. Jennings ◽  
Paula L. Croxson ◽  
Trevor Sharp ◽  
...  
Keyword(s):  
Decision Making ◽  
Nucleus Accumbens ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
6 Hydroxydopamine
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