Protein kinase involvement in land snail aestivation and anoxia: Protein kinase A kinetic properties and changes in second messenger compounds during depressed metabolism

1996 ◽  
Vol 156 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Stephen P. J. Brooks ◽  
Kenneth B. Storey
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Second Messenger ◽  
Land Snail ◽  
Kinetic Properties ◽  
Kinase A

Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling

2006 ◽  
Vol 34 (4) ◽  
pp. 495-497 ◽  
Author(s):  
M. Zaccolo ◽  
G. Di Benedetto ◽  
V. Lissandron ◽  
L. Mancuso ◽  
A. Terrin ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Second Messenger ◽  
Restricted Diffusion ◽  
Selective Activation ◽  
Camp Signalling ◽  
Anchoring Proteins ◽  
Structural Mechanisms ◽  
Kinase A

It is becoming increasingly evident that the freely diffusible second messenger cAMP can transduce specific responses by localized signalling. The machinery that underpins compartmentalized cAMP signalling is only now becoming appreciated. Adenylate cyclases, the enzymes that synthesize cAMP, are localized at discrete parts of the plasma membrane, and phosphodiesterases, the enzymes that degrade cAMP, can be targeted to selected subcellular compartments. A-kinase-anchoring proteins then serve to anchor PKA (protein kinase A) close to specific targets, resulting in selective activation. The specific activation of such individual subsets of PKA requires that cAMP is made available in discrete compartments. In this presentation, the molecular and structural mechanisms responsible for compartmentalized PKA signalling and restricted diffusion of cAMP will be discussed.

scholarly journals Imaging of cAMP Levels and Protein Kinase A Activity Reveals That Retinal Waves Drive Oscillations in Second-Messenger Cascades

2006 ◽  
Vol 26 (49) ◽  
pp. 12807-12815 ◽  
Author(s):  
T. A. Dunn ◽  
C.-T. Wang ◽  
M. A. Colicos ◽  
M. Zaccolo ◽  
L. M. DiPilato ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Second Messenger ◽  
Retinal Waves ◽  
Camp Levels ◽  
Kinase A

scholarly journals Plasma Membrane Na+/H+Exchanger Isoforms (NHE-1, −2, and −3) Are Differentially Responsive to Second Messenger Agonists of the Protein Kinase A and C Pathways

1995 ◽  
Vol 270 (49) ◽  
pp. 29209-29216 ◽  
Author(s):  
Ramani A. Kandasamy ◽  
Frank H. Yu ◽  
Robert Harris ◽  
Annie Boucher ◽  
John W. Hanrahan ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Second Messenger ◽  
Kinase A
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