The isolation and genetic characterization of X-linked mutations that affect pyrimidine metabolism in Drosophila melanogaster

1980 ◽  
Vol 180 (2) ◽  
pp. 419-424 ◽  
Author(s):  
Darrel R. Falk ◽  
Edward A. DeBoer
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Characterization ◽  
Pyrimidine Metabolism

Genetic characterization of the 44D-45B region of the Drosophila melanogaster genome based on an F2 lethal screen

2000 ◽  
Vol 263 (1) ◽  
pp. 137-143 ◽  
Author(s):  
T. C. Dockendorff ◽  
S. E. Robertson ◽  
D. L. Faulkner ◽  
T. A. Jongens
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Characterization

scholarly journals GENETIC CHARACTERIZATION OF THE REGION BETWEEN 86F1,2 AND 87B15 ON CHROMOSOME 3 OF DROSOPHILA MELANOGASTER

Genetics ◽  
1981 ◽  
Vol 98 (4) ◽  
pp. 775-789
Author(s):  
J Gausz ◽  
H Gyurkovics ◽  
G Bencze ◽  
A A M Awad ◽  
J J Holden ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Heat Shock ◽  
Genetic Characterization ◽  
Chromosome 3 ◽  
Gene Encoding ◽  
Lethal Mutations ◽  
Complementation Groups ◽  
Shock Locus ◽  
Chromosome Bands

ABSTRACT The region between 86F1,2 and 87B15 on chromosome 3 of Drosophila melanogaster, which contains about 27 polytene chromosome bands including the 87A7 heat-shock locus, has been screened for EMS-induced visible and lethal mutations. We have recovered 268 lethal mutations that fall into 25 complementation groups. Cytogenetic localization of the complementation groups by deficiency mapping is consistent with the notion that each band encodes a single genetic function. We have also screened for mutations at the 87A7 heat shock locus, using a chromosome that has only one copy of the gene encoding the 70,000 dalton heat-shock protein (hsp70). No lethal or visible mutations at 87A7 were identified from 10,719 mutagenized chromosomes, and no female-sterile mutations at 87A7 were recovered from the 1,520 chromosomes whose progeny were tested for female fertility. We found no evidence that a functional hsp70 gene is required for development under laboratory conditions.

scholarly journals The Molecular and Genetic Characterization of Second Chromosome Balancers in Drosophila melanogaster

2018 ◽  
Vol 8 (4) ◽  
pp. 1161-1171 ◽  
Author(s):  
Danny E. Miller ◽  
Kevin R. Cook ◽  
Elizabeth A. Hemenway ◽  
Vivienne Fang ◽  
Angela L. Miller ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Characterization

scholarly journals Genetic analysis of the heterochromatin of chromosome 3 in Drosophila melanogaster. I. Products of compound-autosome detachment.

Genetics ◽  
1988 ◽  
Vol 120 (2) ◽  
pp. 503-517
Author(s):  
G E Marchant ◽  
D G Holm
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Analysis ◽  
Genetic Characterization ◽  
Complementation Analysis ◽  
Chromosome 3 ◽  
Recessive Lethal ◽  
The Third ◽  
Left And Right ◽  
The Right

Abstract The heterochromatin of the third chromosome is the largest uncharacterized region of the Drosophila melanogaster genome, and the last major block of D. melanogaster heterochromatin to be thoroughly analyzed. In the present study, this region was genetically dissected by generating and analyzing a series of attached, detached and reattached third chromosomes. Separate detachment experiments were conducted for all 12 possible combinations of four newly synthesized sister-strand compound-3L and three newly synthesized sister-strand compound-3R chromosomes. A total of 443 recessive lethal detachment products carrying putative heterochromatic deficiencies were tested for complementation in a several-stage complementation analysis. The results revealed the presence of seven separable vital regions in the heterochromatin of chromosome 3. Attempts to reattach deficiency-carrying detachment products established that six of these vital regions are on the left arm, but only one is on the right arm. An analysis of the types and frequencies of detachment-product deficiencies generated in each detachment experiment permitted the genetic characterization of the progenitor compounds. It was also possible to determine the proximal-distal orientation of the genes on each arm, and to identify possible breakpoints for each lethal detachment product produced. The results of this study suggest that vital genes in the heterochromatin of the third chromosome are not randomly distributed between, nor within, the heterochromatic blocks of the left and right arms.

Identification and molecular genetic characterization of the polytene chromosome interbands in Drosophila melanogaster

2011 ◽  
Vol 47 (5) ◽  
pp. 521-532 ◽  
Author(s):  
T. Yu. Vatolina ◽  
S. A. Demakov ◽  
V. F. Semeshin ◽  
I. V. Makunin ◽  
V. N. Babenko ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Polytene Chromosome ◽  
Genetic Characterization ◽  
Molecular Genetic ◽  
Molecular Genetic Characterization

scholarly journals The control of mutational instability by a new mutator gene ofDrosophila melanogaster

1975 ◽  
Vol 25 (2) ◽  
pp. 163-177 ◽  
Author(s):  
R. C. Woodruff
Keyword(s):  
Drosophila Melanogaster ◽  
Mode Of Action ◽  
Genetic Characterization ◽  
Dominant Gene ◽  
Mutator Gene ◽  
Reversion Frequency ◽  
Males And Females ◽  
Mutator Genes

SUMMARYThe isolation and genetic characterization of a new mutator gene,Mutator-forked3N(Mu-f3N), ofDrosophila melanogasterare described. This mutator gene is unique in that it seems to increase specifically the reversion frequency of the unstable mutantforked3N(f3N, 1–56.7), since the frequency of spontaneous sex-linked recessive lethals in males and females and the frequency of reverse mutations at eight additional X-linked alleles were unaffected byMu-f3N. The mutator is a dominant gene that has been mapped to the region betweenf3N(1–56.7) andBeadex-2 (Bx2, 1–59.4) in theXchromosome, and it seems to function only in the ‘ cis’ configuration. The mode of action ofMu-f3Nis compared with that of other mutator genes.

Genetic characterization of the mei-41 locus in Drosophila melanogaster

1989 ◽  
Vol 215 (2) ◽  
pp. 190-199 ◽  
Author(s):  
James M. Mason ◽  
Nita N. Scobie ◽  
Akihiko H. Yamamoto
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Characterization
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