Detection and characterization of acidic compartments (vacuoles) in Chlorella vulgaris 11h cells by 31P-in vivo NMR spectroscopy and cytochemical techniques

1987 ◽  
Vol 148 (2) ◽  
pp. 83-87 ◽  
Author(s):  
K. Kuchitsu ◽  
T. Oh-hama ◽  
M. Tsuzuki ◽  
S. Miyachi
Keyword(s):  
Nmr Spectroscopy ◽  
Chlorella Vulgaris ◽  
In Vivo Nmr ◽  
In Vivo Nmr Spectroscopy ◽  
Acidic Compartments

Quality assessment in in vivo NMR spectroscopy: VI. Multicentre quantification of MRS test signals

1995 ◽  
Vol 13 (1) ◽  
pp. 169-176 ◽  
Author(s):  
R. de Beer ◽  
P. Bachert-Baumann ◽  
W.M.M.J. Bovee ◽  
E. Cady ◽  
J. Chambron ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Quality Assessment ◽  
In Vivo Nmr ◽  
In Vivo Nmr Spectroscopy

Ex Vivo MuEtinuciear NMR Spectroscopy of Perfused, Respiring Rat Brain Slices: Model Studies of Hypoxia, Ischemia, and Excitotoxscit

1997 ◽  
Author(s):  
L. Litt ◽  
M.T. Espanol
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Nmr Spectroscopy ◽  
Clinical Care ◽  
Brain Slices ◽  
In Vivo Nmr ◽  
In Vivo Nmr Spectroscopy ◽  
Permanent Brain Damage ◽  
The Brain

We believe there are important roles for in vivo NMR spectroscopy techniques in studies of protection and treatment in stroke. Perhaps the primary utility of in vivo NMR spectroscopy is to establish the relevance of metabolic integrity, intracellular pH, and intracellular energy stores to concurrent changes occurring both at gross physiological levels (e.g., changes in cerebral blood flow, or blood oxygenation), and at microscopic or cellular levels. It has long been known that the brain is exquisitely sensitive to deprivations of oxygen, glucose, and cerebral blood flow. Routine human surgery on a limb takes place every day with tourniquets stopping all blood flow for up to two hours. In contrast, the deprivation of all blood flow to the brain (global ischemia) for approximately 5 minutes can result in severe, permanent brain damage. Research has gone on for more than 30 years to understand why the brain’s revival time is so much shorter, and to discover brain biochemical interventions that might dramatically extend the brain’s intolerance beyond 5 minutes, and therefore be relevant to protection and treatment of stroke. (Kogure and Hossmann, 1985; 1993) Stroke, defined as a permanent neurologic deficit arising from the death of brain cells, kills ∼ 150,000 people in the U.S.A. each year, and is the third leading cause of death (Feinleib et al., 1993). It is the next malady to escape, once one has dodged death from cardiovascular disease and cancer. Many, if not most, U.S.A. stroke victims will receive neurological clinical care not substantially different from what was provided 30 years ago. Most stroke patients will be put in intensive care units where blood pressure will be regulated and kept in a “safe” range, with the body given supportive care and the brain given an opportunity to heal itself. The problem of stroke is actually quite complex because there are several different kinds of stroke (ischemic, hemorrhagic, etc.), and because numerous systemic physiological factors are of relevance. Nevertheless, exciting advances in brain biochemistry suggest that stroke therapy and prophylaxis axe likely to improve dramatically in the near future (Zivin and Choi, 1991).

In-Vivo NMR Spectroscopy in Patients with Phenylketonuria: Changes of Cerebral Phenylalanine Levels Under Dietary Treatment

1995 ◽  
Vol 26 (04) ◽  
pp. 199-202 ◽  
Author(s):  
H. Möller ◽  
P. Vermathen ◽  
K. Ullrich ◽  
J. Weglage ◽  
H.-G. Koch ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Dietary Treatment ◽  
In Vivo Nmr ◽  
In Vivo Nmr Spectroscopy

Practical aspects of shielded gradient-coil design for localised in vivo NMR spectroscopy and small-scale imaging

1994 ◽  
Vol 12 (4) ◽  
pp. 621-630 ◽  
Author(s):  
Craig D. Eccles ◽  
Stuart Crozier ◽  
Wolfgang Roffman ◽  
David M. Doddrell ◽  
Philip Back ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Gradient Coil ◽  
Small Scale ◽  
Coil Design ◽  
In Vivo Nmr ◽  
In Vivo Nmr Spectroscopy ◽  
Gradient Coil Design

Cerebral metabolic changes induced by MK-801: a 1D (phosphorus and proton) and 2D (proton) in vivo NMR spectroscopy study

1994 ◽  
Vol 643 (1-2) ◽  
pp. 115-124 ◽  
Author(s):  
Isabelle Loubinoux ◽  
Philippe Meric ◽  
Josiane Borredon ◽  
Jean-Loup Correze ◽  
Brigitte Gillet ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Metabolic Changes ◽  
Spectroscopy Study ◽  
Mk 801 ◽  
In Vivo Nmr ◽  
In Vivo Nmr Spectroscopy

In Vivo NMR Spectroscopy of Mammalian Nervous Systems

1986 ◽  
pp. 215-220
Author(s):  
A. L. Benabid ◽  
M. Decorps ◽  
C. Remy ◽  
J. P. Albrand ◽  
M. von Kienlin ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Nervous Systems ◽  
In Vivo Nmr ◽  
In Vivo Nmr Spectroscopy
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