Age-changes of the force-frequency-relationship and the duration of action potential of isolated papillary muscles of guinea pig

1976 ◽  
Vol 35 (4) ◽  
pp. 277-284 ◽  
Author(s):  
E. Rumberger ◽  
J. Timmermann
Keyword(s):  
Guinea Pig ◽  
Action Potential ◽  
Force Frequency ◽  
Papillary Muscles ◽  
Age Changes ◽  
Duration Of Action ◽  
Frequency Relationship

Action potential duration and force-frequency relationship in isolated rabbit, guinea pig and rat cardiac muscle

1996 ◽  
Vol 166 (2) ◽  
pp. 150-155 ◽  
Author(s):  
P. Szigligeti ◽  
C. Pankucsi ◽  
T. B�ny�sz ◽  
A. Varr� ◽  
P. P. N�n�si
Keyword(s):  
Guinea Pig ◽  
Action Potential ◽  
Cardiac Muscle ◽  
Action Potential Duration ◽  
Force Frequency ◽  
Frequency Relationship

Phospholamban-to-SERCA2 ratio controls the force-frequency relationship

1999 ◽  
Vol 276 (3) ◽  
pp. H779-H785 ◽  
Author(s):  
Markus Meyer ◽  
Wolfgang F. Bluhm ◽  
Huaping He ◽  
Steven R. Post ◽  
Frank J. Giordano ◽  
...  
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Transgenic Mice ◽  
Cardiac Myocytes ◽  
Cardiac Contractility ◽  
Adult Rabbit ◽  
Force Frequency ◽  
Papillary Muscles ◽  
Inhibitory Protein ◽  
Frequency Relationship ◽  
Myocyte Contractility

The force-frequency relationship (FFR) describes the frequency-dependent potentiation of cardiac contractility. The interaction of the sarcoplasmic reticulum Ca2+-adenosinetriphosphatase (SERCA2) with its inhibitory protein phospholamban (PLB) might be involved in the control of the FFR. The FFR was analyzed in two systems in which the PLB-to-SERCA2 ratio was modulated. Adult rabbit cardiac myocytes were transduced with adenovirus encoding for SERCA2, PLB, and β-galactosidase (control). After 3 days, the relative PLB/SERCA2 values were significantly different between groups (SERCA2, 0.5; control, 1.0; PLB, 4.5). SERCA2 overexpression shortened relaxation by 23% relative to control, whereas PLB prolonged relaxation by 39% and reduced contractility by 47% (0.1 Hz). When the stimulation frequency was increased to 1.5 Hz, myocyte contractility was increased by 30% in control myocytes. PLB-overexpressing myocytes showed an augmented positive FFR (+78%), whereas SERCA2-transduced myocytes displayed a negative FFR (−15%). A more negative FFR was also found in papillary muscles from SERCA2 transgenic mice. These findings demonstrate that the ratio of phospholamban to SERCA2 is an important component in the control of the FFR.

Force-frequency relationship and rest potentiation in papillary muscles of Siberian ground squirrel in the period of preparation to hibernation

2006 ◽  
Vol 407 (1) ◽  
pp. 74-76 ◽  
Author(s):  
O. V. Nakipova ◽  
L. A. Andreeva ◽  
N. A. Chumaeva ◽  
N. M. Zakharova ◽  
N. I. Kukushkin ◽  
...  
Keyword(s):  
Ground Squirrel ◽  
Force Frequency ◽  
Papillary Muscles ◽  
Frequency Relationship
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