Influence of flupenthixol and flupenthixol-decanoate on methylphenidate and apomorphine-induced compulsive gnawing in mice

1974 ◽  
Vol 34 (2) ◽  
pp. 119-126 ◽  
Author(s):  
A. V. Christensen ◽  
I. M�ller Nielsen
Keyword(s):  
Flupenthixol Decanoate ◽  
Compulsive Gnawing

Imipramine-Flupenthixol Decanoate Interaction

1986 ◽  
Vol 31 (3) ◽  
pp. 235-237 ◽  
Author(s):  
Peter E. Cook ◽  
Stanley W. Dermer ◽  
Joey Cardamone
Keyword(s):  
Iatrogenic Effects ◽  
Flupenthixol Decanoate

The authors describe a case in which flupenthixol decanoate and imipramine were co-administered to a patient with schizophrenia, resulting in extremely high levels of imipramine and its metabolite, desipramine. The literature on the co-administration of neuroleptics and antidepressants is reviewed and guidelines for limiting possible iatrogenic effects of the combination are suggested.

Flupenthixol decanoate

Reactions ◽  
1984 ◽  
Vol 97 (1) ◽  
pp. 7-7
Keyword(s):  
Flupenthixol Decanoate

Radioimmunoassay for flupenthixol in plasma.

1977 ◽  
Vol 23 (11) ◽  
pp. 2085-2088 ◽  
Author(s):  
J D Robinson ◽  
D Risby
Keyword(s):  
Oral Dose ◽  
Sustained Release ◽  
Single Oral Dose ◽  
Plasma Sample ◽  
Cross Reactivity ◽  
Neuroleptic Drug ◽  
Release Preparation ◽  
Routine Monitoring ◽  
Depot Injections ◽  
Flupenthixol Decanoate

Abstract We describe a radioimmunoassay for the neuroleptic drug flupenthixol, suitable for routine monitoring of its concentration in blood. Antibodies for the assay were raised in a sheep against a 7-carboxyflupenthixol/ovalbumin conjugate. The resulting assay, with [3H] flupenthixol as the label, is capable of detecting 2.0 microgram of flupenthixol per liter, in a 100-microliter plasma sample. The antiserum shows no cross reactivity with tricyclic drugs and low interference from the major metabolites of flupenthixol. Concentrations in plasma after a single oral dose of flupenthixol have been followed in one volunteer. Peak values were reached after 3 h. Determinations of flupenthixol after fortnightly intramuscular depot injections of the sustained-release preparation, flupenthixol decanoate, showed the extent of fluctuations during this period.

A Controlled Comparison of Flupenthixol Decanoate Injections and Oral Amitriptyline in Depressed Out-Patients

1982 ◽  
Vol 140 (3) ◽  
pp. 287-291 ◽  
Author(s):  
W. Tam ◽  
J. P. R. Young ◽  
G. John ◽  
M. H. Lader
Keyword(s):  
Depressive Disorders ◽  
Low Dose ◽  
Rating Scales ◽  
Wide Spectrum ◽  
Double Blind ◽  
Extrapyramidal Signs ◽  
Before And After ◽  
Pre Treatment ◽  
Short Courses ◽  
Flupenthixol Decanoate

SummarySixty-eight depressed out-patients were allocated to treatment with either oral amitriptyline (75–225 mg/day) or intramuscular flupenthixol decanoate (10–30 mg every 14 days) in flexible dosage for 12 weeks under double-blind procedures. Various observer- and self-rating scales were applied before and after 2, 4, 8 and 12 weeks of treatment. Twenty-four patients completed the course of amitriptyline and 20 the course of flupenthixol. All variables improved over time, but there were no significant differences between the two drugs. The Newcastle scores pre-treatment were not related to drug response suggesting that both drugs were similarly effective across a wide spectrum of depressive disorders. Patients on amitriptyline tended to complain of dry mouth; those on flupenthixol had a higher incidence of extrapyramidal signs, the majority receiving anti-parkinsonian drugs at some time during the treatment. Flupenthixol decanoate in low dose is a useful anti-depressant, but should be restricted to short courses of treatment, to patients refractory to other treatments, and to patients suspected of poor compliance.

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