scholarly journals Long-term effect of Ph on B-cell function in isolated islets of langerhans in tissue culture

Diabetologia ◽  
1978 ◽  
Vol 15 (3) ◽  
pp. 181-185 ◽  
Author(s):  
J. Brunstedt ◽  
J. H. Nielsen
Keyword(s):  
Tissue Culture ◽  
B Cell ◽  
Islets Of Langerhans ◽  
Cell Function ◽  
Term Effect ◽  
Isolated Islets ◽  
B Cell Function ◽  
Isolated Islets Of Langerhans ◽  
Long Term Effect

Effect of Long-term Administration of Insulin and Glibenclamide on Pancreatic A and B Cell Function

2009 ◽  
Vol 95 (02) ◽  
pp. 237-241 ◽  
Author(s):  
T. Ikeda ◽  
K. Fujiyama ◽  
T. Hoshino ◽  
T. Takeuchi ◽  
H. Mashiba ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Function ◽  
B Cell Function ◽  
Term Administration

Glucoregulatory response to moderate exercise in long-term islet cell autografted dogs

1990 ◽  
Vol 68 (10) ◽  
pp. 1308-1312 ◽  
Author(s):  
Andrew J. Portis ◽  
Garth L. Warnock ◽  
Diane T. Finegood ◽  
Angelo N. Belcastro ◽  
Ray V. Rajotte
Keyword(s):  
Islets Of Langerhans ◽  
Plasma Glucose ◽  
Isolated Islets ◽  
Strongly Correlated ◽  
Pancreatic Transplantation ◽  
Glucose Levels ◽  
Isolated Islets Of Langerhans ◽  
Exercise Induced ◽  
Pancreatectomized Dogs

The glucoregulatory response to moderate treadmill exercise ([Formula: see text]60% maximum heart rate; 60 min at 100 m/min, 12% grade) was examined in six controls and six pancreatectomized dogs that had been normoglycemic and insulin independent for more than 1 year since autograft of isolated islets of Langerhans (Tx). There were no significant intergroup differences in plasma glucose levels during exercise, but return to baseline after exercise was delayed in Tx (p < 0.05). In Tx, the initially suppressed insulin levels rose above baseline from 30 to 60 min. Within Tx, exercise-induced levels of plasma glucagon and epinephrine were more variable than control and strongly correlated (r = 0.81, p < 0.001), perhaps indicating that the A cells within the grafted islets were regulated by circulating β-adrenergic agonists. We conclude that the isolated islets were removed from direct central control. In Tx dogs, the variable counterregulatory responses and the diminished recovery of plasma glucose after exercise indicate reliance on alternative glucoregulatory mechanisms.Key words: pancreatic transplantation, islets of Langerhans, exercise, glucose.

Long-term effect of bezafibrate on pancreatic beta-cell function and insulin resistance in patients with diabetes

2007 ◽  
Vol 194 (1) ◽  
pp. 265-271 ◽  
Author(s):  
Helena Tenenbaum ◽  
Solomon Behar ◽  
Valentina Boyko ◽  
Yehuda Adler ◽  
Enrique Z. Fisman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Term Effect ◽  
Long Term Effect ◽  
Patients With Diabetes ◽  
Pancreatic Beta Cell Function
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