Influence of bone and soft-tissue operations on serum concentrations of growth hormone, somatomedin C and alkaline phosphatase

1990 ◽  
Vol 109 (5) ◽  
pp. 272-276 ◽  
Author(s):  
H. -R. Casser ◽  
K. -W. Zilkens ◽  
R. Forst ◽  
A. Br�ggemann
Keyword(s):  
Growth Hormone ◽  
Alkaline Phosphatase ◽  
Soft Tissue ◽  
Serum Concentrations ◽  
Somatomedin C

Effect of growth hormone on osteoblasts and demonstration of somatomedin-C/IGF I in bone organ culture

1984 ◽  
Vol 107 (1) ◽  
pp. 16-24 ◽  
Author(s):  
H. Stracke ◽  
A. Schulz ◽  
D. Moeller ◽  
S. Rossol ◽  
H. Schatz
Keyword(s):  
Growth Hormone ◽  
Alkaline Phosphatase ◽  
Organ Culture ◽  
Culture Medium ◽  
Bone Cells ◽  
Electron Microscopic ◽  
Continuous Increase ◽  
Somatomedin C ◽  
Igf I ◽  
Bone Organ Culture

Abstract. Bone organ culture makes it possible to observe the direct influence of hormones on bone cells. We studied the effect of growth hormone in vitro on embryonal rat tibiae during culture for 7 days, functionally by measuring the levels of alkaline phosphatase in the culture medium, and morphologically by means of semithin sections and electron microscopic examination. Since growth hormone (GH) is supposed to exert an indirect effect on bone cells, somatomedin-C/insulin-like growth factor I (SM-C/IGF I) as a possible mediator was also measured radioimmunologically in the culture medium. In the controls alkaline phosphatase levels showed a continuous increase up to the 7th day which was significantly higher in the presence of GH. There was also a significantly enhanced increase of SM-C/IGF I in the presence of GH during culture in comparison to the controls. Evidently IGF I is produced locally in bone and mediates the effect of GH on bone formation.

scholarly journals Responses of serum GH and somatomedin-C to an analogue of GHRH in children with growth hormone deficiency

1984 ◽  
Vol 18 (11) ◽  
pp. 1206-1206
Author(s):  
A Grossman ◽  
M O Savage ◽  
A Blacklay ◽  
N Lytras ◽  
P N Plowman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Somatomedin C ◽  
Serum Gh

Effect of Growth Hormone-Releasing Factor on Plasma Growth Hormone, Prolactin and Somatomedin C in Hypopituitary and Short Normal Children

1985 ◽  
Vol 22 (1-2) ◽  
pp. 32-45 ◽  
Author(s):  
Guy Van Vliet ◽  
Danièle Bosson ◽  
Claude Robyn ◽  
Margareta Craen ◽  
Paul Malvaux ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Plasma Growth Hormone ◽  
Normal Children ◽  
Somatomedin C ◽  
Growth Hormone Releasing Factor

Reduced Serum Somatomedin Activity in Patients with Chronic Liver Disease

1974 ◽  
Vol 47 (4) ◽  
pp. 359-366 ◽  
Author(s):  
A. Wu ◽  
D. B. Grant ◽  
Judy Hambley ◽  
A. J. Levi
Keyword(s):  
Growth Hormone ◽  
Alkaline Phosphatase ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Severe Disease ◽  
Chronic Liver ◽  
Hormone Deficiency ◽  
Factor Activity ◽  
Important Site ◽  
Low Serum

1. Somatomedin (SM; sulphation factor) activity was estimated by a chick-cartilage assay in fasting sera from twenty-one patients with chronic liver disease. 2. Low SM values were found in nine out of the ten patients with cirrhosis and in two other patients, one with hepatofibrosis and one with hepatoma. 3. In general, the lowest serum SM activities were found in those patients with the most severe disease and significant correlations were found between serum SM and serum albumin, alkaline phosphatase and bilirubin. 4. Growth hormone was also measured in the samples and concentrations above 10 units/ml were found in seven patients, all of whom had reduced serum SM activities. 5. These findings indicate that low serum SM activity in liver disease is not related to growth hormone deficiency and suggest that the liver may be an important site for SM synthesis in man.

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