scholarly journals The effect of ascorbic acid on protein glycation in streptozotocin-diabetic rats

Diabetologia ◽  
1994 ◽  
Vol 37 (7) ◽  
pp. 731-731 ◽  
Author(s):  
M. Gembal ◽  
J. Drużyńska ◽  
M. Kowalczyk ◽  
E. Przepiera ◽  
M. Cybal ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Diabetic Rats ◽  
Protein Glycation ◽  
Streptozotocin Diabetic Rats

Lens protein glycation and the subsequent degree of opacity in streptozotocin-diabetic rats

1989 ◽  
Vol 7 (4) ◽  
pp. 259-262 ◽  
Author(s):  
Mitsuyasu Yano ◽  
Satoshi Matsuda ◽  
Yasuharu Bando ◽  
Kenji Shima
Keyword(s):  
Diabetic Rats ◽  
Protein Glycation ◽  
Lens Protein ◽  
Streptozotocin Diabetic Rats

scholarly journals Curcumin, Alone or in Combination with Aminoguanidine, Increases Antioxidant Defenses and Glycation Product Detoxification in Streptozotocin-Diabetic Rats: A Therapeutic Strategy to Mitigate Glycoxidative Stress

2020 ◽  
Vol 2020 ◽  
pp. 1-16
Author(s):  
Tayra Ferreira Oliveira Lima ◽  
Mariana Campos Costa ◽  
Ingrid Delbone Figueiredo ◽  
Maiara Destro Inácio ◽  
Maria Rita Rodrigues ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Diabetic Complications ◽  
Therapeutic Option ◽  
Diabetic Rats ◽  
Protein Glycation ◽  
Antioxidant Defenses ◽  
Paraoxonase 1 ◽  
Advanced Glycation ◽  
Early Protein ◽  
Streptozotocin Diabetic Rats

Both oxidative stress and the exacerbated generation of advanced glycation end products (AGEs) have crucial roles in the onset and progression of diabetic complications. Curcumin has antioxidant and antidiabetic properties; its combination with compounds capable of preventing the advanced glycation events, such as aminoguanidine, is an interesting therapeutic option to counteract diabetic complications. This study is aimed at investigating the effects of treatments with curcumin or aminoguanidine, alone or in combination, on metabolic alterations in streptozotocin-diabetic rats; the focus was mainly on the potential of these bioactive compounds to oppose the glycoxidative stress. Curcumin (90 mg/kg) or aminoguanidine (50 and 100 mg/kg), alone or in combination, slightly decreased glycemia and the biomarkers of early protein glycation, but markedly decreased AGE levels (biomarkers of advanced glycation) and oxidative damage biomarkers in the plasma, liver, and kidney of diabetic rats. Some novel insights about the in vivo effects of these bioactive compounds are centered on the triggering of cytoprotective machinery. The treatments with curcumin and/or aminoguanidine increased the activities of the antioxidant enzymes (paraoxonase 1, superoxide dismutase, and catalase) and the levels of AGE detoxification system components (AGE-R1 receptor and glyoxalase 1). In addition, combination therapy between curcumin and aminoguanidine effectively prevented dyslipidemia in diabetic rats. These findings demonstrate the combination of curcumin (natural antioxidant) and aminoguanidine (prototype therapeutic agent with anti-AGE activity) as a potential complementary therapeutic option for use with antihyperglycemic agents, which may aggregate beneficial effects against diabetic complications.

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