Effects of different amino-group reagents on ribosomal integrity: structural role of lysine residues

1986 ◽  
Vol 11 (1) ◽  
pp. 47-50 ◽  
Author(s):  
A. Vioque ◽  
F. Hern�ndez ◽  
E. Palaci�n
Keyword(s):  
Amino Group ◽  
Structural Role ◽  
Lysine Residues

scholarly journals Rearrangement of nucleosomal components by modification of histone amino groups. Structural role of lysine residues

Biochemistry ◽  
1984 ◽  
Vol 23 (19) ◽  
pp. 4280-4284 ◽  
Author(s):  
Juan Jordano ◽  
Francisco Montero ◽  
Enrique Palacian
Keyword(s):  
Amino Groups ◽  
Structural Role ◽  
Lysine Residues

Role of Methylglyoxal in Diabetic Cardiovascular and Kidney Diseases: Insights from Basic Science for Application into Clinical Practice

2018 ◽  
Vol 24 (26) ◽  
pp. 3072-3083 ◽  
Author(s):  
Sowndramalingam Sankaralingam ◽  
Angham Ibrahim ◽  
MD Mizanur Rahman ◽  
Ali H. Eid ◽  
Shankar Munusamy
Keyword(s):  
Therapeutic Strategy ◽  
Kidney Diseases ◽  
Vascular Dysfunction ◽  
Dicarbonyl Compound ◽  
Renal Complications ◽  
Lysine Residues ◽  
Patients With Diabetes ◽  
Prevalence Of Diabetes Mellitus

Background: The incidence and prevalence of diabetes mellitus are increasing globally at alarming rates. Cardiovascular and renal complications are the major cause of morbidity and mortality in patients with diabetes. Methylglyoxal (MG) - a highly reactive dicarbonyl compound – is increased in patients with diabetes and has been implicated to play a detrimental role in the etiology of cardiovascular and renal complications. Derived from glucose, MG binds to arginine and lysine residues in proteins, and the resultant end products serve as surrogate markers of MG generation in vivo. Under normal conditions, MG is detoxified by the enzyme glyoxalase 1 (Glo1), using reduced glutathione as a co-factor. Elevated levels of MG is known to cause endothelial and vascular dysfunction, oxidative stress and atherosclerosis; all of which are risk factors for cardiovascular diseases. Moreover, MG has also been shown to cause pathologic structural alterations and impair kidney function. Conversely, MG scavengers (such as N-acetylcysteine, aminoguanidine or metformin) or Nrf2/Glo1 activators (such as trans-resveratrol / hesperetin) are shown to be useful in preventing MG-induced cardiovascular and renal complications in diabetes. However, clinical evidence supporting the MG lowering properties of these agents are limited and hence, need further investigation. Conclusion: Reducing MG levels directly using scavengers or indirectly via activation of Nrf2/Glo1 may serve as a novel and potent therapeutic strategy to counter the deleterious effects of MG in diabetic complications.

The Role of Solid Springer in Masonry Vault

2010 ◽  
Vol 133-134 ◽  
pp. 349-354 ◽  
Author(s):  
Vittorio Ceradini ◽  
Michele Candela ◽  
Roberta Fonti
Keyword(s):  
Scientific Research ◽  
Evolution Process ◽  
Limit Case ◽  
Structural Configuration ◽  
Structural Role ◽  
Different Ages ◽  
Building Component ◽  
And Function ◽  
Technical Rules

During a scientific research, directed to understand the structural role of some particular masonry elements, noticeable in covering structures like vault and dome, we searched the technical rules and function of these elements. We verified that in literature there is no specific documentation about these elements and its mechanic purposes. The study was directed to recognize the most representatives architectures in different ages, and to identify the construction technique’s evolution process of this particular arc-double or thickening of arc that we arrived to identify as a necessary building component to give balance in particular structural configuration. This process put down roots from the roman ancient age, until baroque age, where the most original applications of this regulation were placed. From Pantheon to the limit case of St. Filippo Neri chapel, the covers’ structures springer angle studied was analyzed together with its relation to plan, sections and elevation of all buildings. Therefore, if these elements are well-performed, they follow precise constructive patterns that this article would like to identify and show.

Molecular Basis for Nucleotide-binding Specificity: Role of the Exocyclic Amino Group “N2” in Recognition by a Guanylyl-ribonuclease

2006 ◽  
Vol 355 (1) ◽  
pp. 72-84 ◽  
Author(s):  
Greta L. Schrift ◽  
Travis T. Waldron ◽  
Mitchell A. Timmons ◽  
S. Ramaswamy ◽  
William R. Kearney ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Binding Specificity ◽  
Nucleotide Binding ◽  
Amino Group

scholarly journals Structure and solubility behaviour of zinc containing phosphate glasses

2015 ◽  
Vol 3 (45) ◽  
pp. 8842-8855 ◽  
Author(s):  
N. Kanwal ◽  
H. Toms ◽  
A. C. Hannon ◽  
F. A. Perras ◽  
D. L. Bryce ◽  
...  
Keyword(s):  
Phosphate Glasses ◽  
Structural Role ◽  
Role Of Zn

The structural role of Zn and its effect on solubility in phosphate based bioglasses is investigated.

scholarly journals Catalytic and structural role of the metal ion in dUTP pyrophosphatase

2003 ◽  
Vol 100 (10) ◽  
pp. 5670-5675 ◽  
Author(s):  
D. Mustafi ◽  
A. Bekesi ◽  
B. G. Vertessy ◽  
M. W. Makinen
Keyword(s):  
Metal Ion ◽  
Structural Role
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