Influence of cyclic AMP on the growth response and anaerobic metabolism of carbon monoxide in Rhodocyclus gelatinosus

Patti A. Murray; Robert L. Uffen

doi:10.1007/bf00411648

Carbon monoxide-induced activation of gene expression in Rhodospirillum rubrum requires the product of cooA, a member of the cyclic AMP receptor protein family of transcriptional regulators.

Journal of Bacteriology ◽

10.1128/jb.177.8.2157-2163.1995 ◽

1995 ◽

Vol 177 (8) ◽

pp. 2157-2163 ◽

Cited By ~ 69

Author(s):

D Shelver ◽

R L Kerby ◽

Y He ◽

G P Roberts

Keyword(s):

Gene Expression ◽

Carbon Monoxide ◽

Cyclic Amp ◽

Rhodospirillum Rubrum ◽

Transcriptional Regulators ◽

Protein Family ◽

Receptor Protein ◽

Cyclic Amp Receptor Protein

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Membrane topography of anaerobic carbon monoxide oxidation in Rhodocyclus gelatinosus.

Journal of Bacteriology ◽

10.1128/jb.169.10.4784-4789.1987 ◽

1987 ◽

Vol 169 (10) ◽

pp. 4784-4789 ◽

Cited By ~ 10

Author(s):

J E Champine ◽

R L Uffen

Keyword(s):

Carbon Monoxide ◽

Carbon Monoxide Oxidation ◽

Membrane Topography ◽

Rhodocyclus Gelatinosus

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Carbon monoxide rescues ischemic lungs by interrupting MAPK-driven expression of early growth response 1 gene and its downstream target genes

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.0600241103 ◽

2006 ◽

Vol 103 (13) ◽

pp. 5191-5196 ◽

Cited By ~ 73

Author(s):

S. Mishra ◽

T. Fujita ◽

V. N. Lama ◽

D. Nam ◽

H. Liao ◽

...

Keyword(s):

Carbon Monoxide ◽

Growth Response ◽

Target Genes ◽

Early Growth ◽

Early Growth Response ◽

Downstream Target ◽

Early Growth Response 1

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THE EFFECT OF SPECIFIC POISONS UPON THE PHOTO-REDUCTION WITH HYDROGEN IN GREEN ALGAE

The Journal of General Physiology ◽

10.1085/jgp.26.2.195 ◽

1942 ◽

Vol 26 (2) ◽

pp. 195-217 ◽

Cited By ~ 44

Author(s):

Hans Gaffron

Keyword(s):

Carbon Monoxide ◽

Anaerobic Metabolism ◽

Specific Inhibitor ◽

The Other ◽

Enzymatic Reactions ◽

Hydrogen Metabolism ◽

Anaerobic Conditions ◽

Prolonged Incubation ◽

Low Concentrations ◽

Evolution Of Oxygen

1. The effect of poisons upon the photoreduction with hydrogen in Scenedesmus and similar algae has been studied. The poisons used were cyanide, hydroxylamine, dinitrophenol, and carbon monoxide, substances known to inhibit more or less specifically certain enzymatic reactions. 2. It was found that quite generally one has to distinguish between the action of poisons upon the photoreduction in the stationary state, once this type of metabolism has been well established in the cells, and their effects on transition phenomena, on the "adaptation" and its reversal, the "turnback" from photoreduction to photosynthesis. 3. Cyanide inhibits photoreduction more strongly than it inhibits photosynthesis in the same algae. It is concluded that the mechanism of oxygen liberation, which is idle in photoreduction, is not very sensitive to cyanide. 4. Hydroxylamine in low concentrations is a powerful inhibitor of photosynthesis but has practically no influence on the rate of photoreduction. Consequently, it is assumed that it acts in photosynthesis mainly by inhibiting the evolution of oxygen. Greater concentrations of hydroxylamine clearly inhibit photoreduction, but diminish the rate to about one-half only. A greater degree of inhibition is obtained only by prolonged incubation. 5. Dinitrophenol was found to inhibit strongly the reduction of carbon dioxide, under aerobic as well as under anaerobic conditions. A stimulating effect of dinitrophenol can be demonstrated only with respiration or fermentation, not with photosynthesis. 6. Carbon monoxide interferes with all phases of the hydrogen metabolism in algae. It is supposed therefore to be a specific inhibitor for the hydrogenase system. 7. The "adaptation" to the hydrogen metabolism, which takes place if the algae are incubated anaerobically in hydrogen for several hours, is inhibited completely by very small amounts of cyanide. The adaptation reaction is more sensitive to cyanide than most of the other metabolic processes in the same cell. Correspondingly cyanide enhances the return to aerobic conditions, the "turnback," which occurs under the influence of light of high intensities. 8. Hydroxylamine, applied aerobically, inhibits the adaptation reaction to about the same degree as it inhibits photosynthesis. Photoreduction proceeds after the adaptation in presence of hydroxylamine only at a fraction of the rate that it would have if the poison were added later. 9. Hydroxylamine in concentrations of 10–3 M protects the anaerobic metabolism against the return to aerobic photosynthesis which normally occurs under the influence of light of too high intensity. The protection is only relative and the higher the light intensity the more hydroxylamine is needed to keep photoreduction going. Once a "turnback" occurs in presence of much hydroxylamine all photochemical gas exchange comes to an end.

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Cytochemical Evidence for Presynatic β-Adrenergic Regulation of Secretion in the Developing Rat Submandibular Gland

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100079590 ◽

1977 ◽

Vol 35 ◽

pp. 430-431

Author(s):

L.S. Cutler

Keyword(s):

Cyclic Amp ◽

Adenylate Cyclase ◽

Submandibular Gland ◽

Neonatal Rat ◽

Cyclase Activity ◽

Adenylate Cyclase Activity ◽

Parotid Glands ◽

Adrenergic Agonist ◽

Rat Submandibular Gland

Many studies previously have shown that the B-adrenergic agonist isoproterenol and the a-adrenergic agonist norepinephrine will stimulate secretion by the adult rat submandibular (SMG) and parotid glands. Recent data from several laboratories indicates that adrenergic agonists bind to specific receptors on the secretory cell surface and stimulate membrane associated adenylate cyclase activity which generates cyclic AMP. The production of cyclic AMP apparently initiates a cascade of events which culminates in exocytosis. During recent studies in our laboratory it was observed that the adenylate cyclase activity in plasma membrane fractions derived from the prenatal and early neonatal rat submandibular gland was retractile to stimulation by isoproterenol but was stimulated by norepinephrine. In addition, in vitro secretion studies indicated that these prenatal and neonatal glands would not secrete peroxidase in response to isoproterenol but would secrete in response to norepinephrine. In contrast to these in vitro observations, it has been shown that the injection of isoproterenol into the living newborn rat results in secretion of peroxidase by the SMG (1).

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Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors

Biochemical Society Transactions ◽

10.1042/bst20190246 ◽

2019 ◽

Vol 47 (6) ◽

pp. 1733-1747 ◽

Cited By ~ 3

Author(s):

Christina Klausen ◽

Fabian Kaiser ◽

Birthe Stüven ◽

Jan N. Hansen ◽

Dagmar Wachten

Keyword(s):

Cyclic Amp ◽

Adenosine Monophosphate ◽

Adenylyl Cyclases ◽

Temporal Precision ◽

Fluorescent Biosensors ◽

Subcellular Domains ◽

Spatio Temporal ◽

Hydrolysis Of ◽

Shed Light ◽

Cyclic Amp Signaling

The second messenger 3′,5′-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil specific functions. To define the function of cAMP within these microdomains, signaling needs to be analyzed with spatio-temporal precision. To this end, optogenetic approaches and genetically encoded fluorescent biosensors are particularly well suited. Synthesis and hydrolysis of cAMP can be directly manipulated by photoactivated adenylyl cyclases (PACs) and light-regulated phosphodiesterases (PDEs), respectively. In addition, many biosensors have been designed to spatially and temporarily resolve cAMP dynamics in the cell. This review provides an overview about optogenetic tools and biosensors to shed light on the subcellular organization of cAMP signaling.

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