Rapid and efficient construction of yeast artificial chromosome contigs in the mouse genome with interspersed repetitive sequence PCR (IRS-PCR): Generation of a 5-cM, >5 megabase contig on mouse Chromosome 1

1994 ◽  
Vol 5 (10) ◽  
pp. 597-607 ◽  
Author(s):  
K. W. Hunter ◽  
S. D. Ontiveros ◽  
M. L. Watson ◽  
V. P. Stanton ◽  
P. Gutierrez ◽  
...  
Keyword(s):  
Mouse Chromosome ◽  
Repetitive Sequence ◽  
Mouse Genome ◽  
Yeast Artificial Chromosome ◽  
Artificial Chromosome ◽  
Chromosome 1 ◽  
Efficient Construction ◽  
Mouse Chromosome 1

scholarly journals Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.

1990 ◽  
Vol 172 (1) ◽  
pp. 263-272 ◽  
Author(s):  
M L Watson ◽  
S F Kingsmore ◽  
G I Johnston ◽  
M H Siegelman ◽  
M M Le Beau ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Leukocyte Adhesion ◽  
Evolutionary Relationship ◽  
Coagulation Factor ◽  
Chromosome 1 ◽  
Range Restriction ◽  
Human Chromosome 1 ◽  
Human And Mouse ◽  
Mouse Chromosome 1

A structurally and functionally related group of genes, lymph node homing receptor (LHR), granule membrane protein 140 (GMP-140), and endothelial leukocyte adhesion molecule 1 (ELAM-1) are shown to constitute a gene cluster on mouse and human chromosome 1. In situ hybridization mapped GMP-140 to human chromosome 1 bands 21-24 consistent with chromosomal localization of LHR. Gene linkage analysis in the mouse indicated that these genes and serum coagulation factor V (FV) all map to a region of distal mouse chromosome 1 that is syntenic with human chromosome 1, with no crossovers identified between these four genes in 428 meiotic events. Moreover, long range restriction site mapping demonstrated that these genes map to within 300 kb in both the human and mouse genomes. These data suggest that LHR, ELAM-1, and GMP-140 comprise an adhesion protein family, the selectins, that arose by multiple gene duplication events before divergence of mouse and human. Furthermore, the location of these genes on mouse and human chromosome 1 is consistent with a close evolutionary relationship to the complement receptor-related genes, which also are positioned on the same chromosomes in both species and with which these genes share a region of sequence homology. These data characterize the organization of a genomic region that may be critical for intercellular communication within the immune system.

Mapping of the bcl-2oncogene on mouse chromosome 1

1988 ◽  
Vol 47 (1-2) ◽  
pp. 11-15 ◽  
Author(s):  
B.A. Mock ◽  
D. Givol ◽  
L.A. Dhoostelaere ◽  
K. Huppi ◽  
M.F. Seldin ◽  
...  
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 1 ◽  
Mouse Chromosome 1

scholarly journals Identification of novel mouse genes conferring posthypoxic pauses

2012 ◽  
Vol 113 (1) ◽  
pp. 167-174 ◽  
Author(s):  
C. Barton Gillombardo ◽  
Motoo Yamauchi ◽  
Mark D. Adams ◽  
Jesse Dostal ◽  
Sam Chai ◽  
...  
Keyword(s):  
Mouse Chromosome ◽  
Periodic Breathing ◽  
Chromosome 1 ◽  
Chromosome Substitution Strain ◽  
Peptide Fragment ◽  
Chromosome Substitution ◽  
Phenotypic Analysis ◽  
Respiratory Rhythmogenesis ◽  
The Impact ◽  
Mouse Chromosome 1

Although central to the susceptibility of adult diseases characterized by abnormal rhythmogenesis, characterizing the genes involved is a challenge. We took advantage of the C57BL/6J (B6) trait of hypoxia-induced periodic breathing and its absence in the C57BL/6J-Chr 1A/J/NaJ chromosome substitution strain to test the feasibility of gene discovery for this abnormality. Beginning with a genetic and phenotypic analysis of an intercross study between these strains, we discovered three quantitative trait loci (QTLs) on mouse chromosome 1, with phenotypic effects. Fine-mapping reduced the genomic intervals and gene content, and the introgression of one QTL region back onto the C57BL/6J-Chr 1A/J/NaJ restored the trait. mRNA expression of non-synonymous genes in the introgressed region in the medulla and pons found evidence for differential expression of three genes, the highest of which was apolipoprotein A2, a lipase regulator; the apo a2 peptide fragment (THEQLTPLVR), highly expressed in the liver, was expressed in low amounts in the medulla but did not correlate with trait expression. This work directly demonstrates the impact of elements on mouse chromosome 1 in respiratory rhythmogenesis.

Mapping of alpha-spectrin on distal mouse chromosome 1

1987 ◽  
Vol 45 (1) ◽  
pp. 52-54 ◽  
Author(s):  
M.F. Seldin ◽  
H.C. Morse, III ◽  
L. D’Hoostelaere ◽  
J.L. Britten ◽  
A.D. Steinberg
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 1 ◽  
Distal Mouse Chromosome ◽  
Distal Mouse ◽  
Alpha Spectrin ◽  
Mouse Chromosome 1

scholarly journals A Torrid Zone on Mouse Chromosome 1 Containing a Cluster of Recombinational Hotspots

Genetics ◽  
2004 ◽  
Vol 169 (2) ◽  
pp. 833-841 ◽  
Author(s):  
Peter M. Kelmenson ◽  
Petko Petkov ◽  
Xiaosong Wang ◽  
David C. Higgins ◽  
Beverly J. Paigen ◽  
...  
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 1 ◽  
Mouse Chromosome 1

scholarly journals Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome 1

Parasitology ◽  
2014 ◽  
Vol 142 (04) ◽  
pp. 566-575
Author(s):  
HARRY NOYES ◽  
JOHN GITHIORI ◽  
JAN E. BRADLEY ◽  
STEVE KEMP ◽  
JERZY M. BEHNKE
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 1 ◽  
Heligmosomoides Bakeri ◽  
Mouse Chromosome 1

Genetic and contig map of a 2200-kb region encompassing 5.5 cM on chromosome 1 of Arabidopsis thaliana

Genome ◽  
1996 ◽  
Vol 39 (6) ◽  
pp. 1086-1092 ◽  
Author(s):  
Christian S. Hardtke ◽  
Thomas Berleth
Keyword(s):  
Arabidopsis Thaliana ◽  
Positional Cloning ◽  
Yeast Artificial Chromosome ◽  
Physical Map ◽  
Primary Root ◽  
Artificial Chromosome ◽  
Chromosome 1 ◽  
Rflp Markers ◽  
Caps Markers ◽  
Yac Contig

In the course of the isolation of the MONOPTEROS (MP) gene, required for primary root formation in Arabidopsis thaliana, a yeast artificial chromosome (YAC) contig encompassing approximately 2200 kilobases corresponding to 5.5 cM on the top arm of chromosome 1 was established. Forty-six YAC clones were characterized and 12 new restriction fragment length polymorphism (RFLP) markers are presented. Three new codominant amplified polymorphic sequence (CAPS) markers were generated that enabled high resolution genetic mapping and correlation of physical and genetic distances along the contig. The map contributes to the completion of a physical map of the Arabidopsis genome and should facilitate positional cloning of other genes in the region as well as studies on genome organization. We also present another set of 11 physically linked probes, as well as mapping data for additional RFLP markers within a broader interval of 10.4 cM. Key words : Arabidopsis, CAPS markers, MONOPTEROS gene, physical map, RFLP markers, YAC contig.

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