A comparative study of two long acting phenothiazine preparations, fluphenazine-enanthate and fluphenazine-decanoate

1966 ◽  
Vol 9 (4) ◽  
pp. 320-327 ◽  
Author(s):  
Albert A. Kurland ◽  
Julia H. Richardson
Keyword(s):  
Comparative Study ◽  
Fluphenazine Decanoate ◽  
Fluphenazine Enanthate ◽  
Long Acting

Long-acting injectable antipsychotic agents

1979 ◽  
Vol 17 (11) ◽  
pp. 41-43
Keyword(s):  
Antipsychotic Agents ◽  
Fluphenazine Decanoate ◽  
Fluphenazine Enanthate ◽  
Long Acting ◽  
Flupenthixol Decanoate

Five long-acting injectable antipsychotic agents (neuroleptics) are available. They are fluphenazine enanthate (Moditen enanthate),1 fluphenazine decanoate (Modecate),2 flupenthixol decanoate (Depixol), cis-clopenthixol decanoate (Clopixol) and fluspirilene (Redeptin).3 Their therapeutic and unwanted effects are broadly similar to those of their oral forms. Nevertheless, injectable preparations have distinct advantages as well as problems.

The Side-Effects of Fluphenazine Decanoate

1973 ◽  
Vol 123 (576) ◽  
pp. 519-522 ◽  
Author(s):  
D. A. W. Johnson
Keyword(s):  
Side Effects ◽  
Clinical Situation ◽  
Fluphenazine Decanoate ◽  
Clinical Control ◽  
Hyper Sensitivity ◽  
Fluphenazine Enanthate ◽  
Extrapyramidal Effects ◽  
Low Incidence ◽  
Long Acting ◽  
Dose Dependent

The unwanted effects of the phenothiazines can be divided into two categories; those effects which represent the pharmacodynamic actions of a particular drug and occur as a function of dosage and individual susceptibility; and the hyper-sensitivity reactions (Shepherd et al., 1968). This latter group of side-effects is relatively rare, and there is no suggestion in the literature that they occur more frequently with the injectable long-acting phenothiazines (LAP) than with the oral forms. With the first available long-acting phenothiazine (fluphenazine enanthate) motor side-effects were frequently observed, particularly during the first few days after injection (Millar and Daniel, 1967; Lowther, 1969; Malm, 1970). Initial studies have suggested that fluphenazine decanoate is less likely to produce these unwanted extrapyramidal effects (Neal and Imlah, 1968; Ayd, 1970). So far, however, no study has attempted to make a quantitative evaluation of the problem of side-effects in the clinical situation of longterm medication. Since both the therapeutic efficacy and the unwanted extra-pyramidal side-effects are dose-dependent, it is meaningless to measure the incidence of side-effects without also recording the therapeutic gain: a low incidence of side-effects might only reflect a non-therapeutic dose of medication. Further, any such study should be continued for at least two months after the last reduction in dosage, as it is well recognized that loss of clinical control may be postponed for many weeks after phenothiazines have been discontinued.

ÉTude Comparative De L'énanthate De Fluphénazine, Du Bichlorhydrate De Fluphénazine Et Du Placebo Chez Le Schizophrène Chronique

1969 ◽  
Vol 14 (2) ◽  
pp. 191-198 ◽  
Author(s):  
Léon Tetreault ◽  
Jean-Marc Bordeleau ◽  
Jean-Marie Albert ◽  
Paul Rajotte
Keyword(s):  
Comparative Study ◽  
Sesame Oil ◽  
Etude Comparative ◽  
Double Blind ◽  
Indirect Measure ◽  
Chronic Schizophrenics ◽  
Significant Difference ◽  
Fluphenazine Enanthate ◽  
Long Acting ◽  
Methodological Aspects

A comparative study of fluphénazine enanthate, a long-acting neuroleptic, fluphénazine bichlorhydrate and placebo was made on 28 chronic schizophrenics. The double-blind technique was possible by giving to the patients one of the three following treatments: the long-acting neuroleptic by injection every fortnight and placebo tablets daily, the standard neuroleptic (tablets) daily and regular injection of sesame oil or the two inactive substances in a similar way. Dosage of fluphénazine enanthate was 25, 50 or 75 mg every fortnight and of bichlorhydrate 10, 20 or 30 mg. daily after a fixed schedule. Antipsychotic action of the drugs was evaluated according to three types of measures: 1) IMPS; 2) NOSIE and 3) need for chlorpromazine given p.r.n. (indirect measure). Results of this study indicate that both fluphénazine salts are superior to placebo and possess significant antipsychotic properties as demonstrated by the indirect measure. No significant difference was found between enanthate and bichlorhydrate of fluphénazine. Some methodological aspects of psychopharmacological research are also discussed.

Comparative study of extended release albuterol sulfate and long-acting inhaled salmeterol xinafoate in the treatment of nocturnal asthma

1999 ◽  
Vol 83 (2) ◽  
pp. 121-126 ◽  
Author(s):  
Richard J. Martin ◽  
Monica Kraft ◽  
Wilfred N. Beaucher ◽  
Frederic Kiechel ◽  
James L. Sublett ◽  
...  
Keyword(s):  
Comparative Study ◽  
Extended Release ◽  
Nocturnal Asthma ◽  
Salmeterol Xinafoate ◽  
Albuterol Sulfate ◽  
Long Acting

Psychopathology and global functioning in schizophrenic patients on depot antypsychotics and long-acting injectable risperidone: A six month comparative study

2007 ◽  
Vol 22 ◽  
pp. S116
Author(s):  
A. Intxausti ◽  
A.L. Morera ◽  
C.C. González-Hernández ◽  
D. Alonso-Diaz ◽  
N. González-Brito ◽  
...  
Keyword(s):  
Comparative Study ◽  
Global Functioning ◽  
Schizophrenic Patients ◽  
Long Acting
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