scholarly journals Glycine fermentation via a glycine reductase in Peptococcus glycinophilus and Peptococcus magnus

1983 ◽  
Vol 134 (2) ◽  
pp. 127-135 ◽  
Author(s):  
Peter D�rre ◽  
Rolf Spahr ◽  
Jan R. Andreesen
Keyword(s):  
Glycine Reductase

scholarly journals Substrate-specific selenoprotein B of glycine reductase from Eubacterium acidaminophilum . Biochemical and molecular analysis

1999 ◽  
Vol 260 (1) ◽  
pp. 38-49 ◽  
Author(s):  
Matthias Wagner ◽  
Denise Sonntag ◽  
Rudolf Grimm ◽  
Andreas Pich ◽  
Christoph Eckerskorn ◽  
...  
Keyword(s):  
Molecular Analysis ◽  
Glycine Reductase

scholarly journals Unique metabolic strategies in Hadean analogues reveal hints for primordial physiology

2021 ◽  
Author(s):  
Masaru Konishi Nobu ◽  
Ryosuke Nakai ◽  
Satoshi Tamazawa ◽  
Hiroshi Mori ◽  
Atsushi Toyoda ◽  
...  
Keyword(s):  
Early Earth ◽  
Carbon Compounds ◽  
Glycine Reductase ◽  
Genes Encoding ◽  
Metabolic Strategies ◽  
Primordial Life ◽  
Core Metabolism ◽  
New View

Primordial microorganisms are postulated to have emerged in H2-rich alkaline Hadean serpentinite-hosted environments with homoacetogenesis as a core metabolism. However, investigation of two modern serpentinization-active analogues of early Earth reveals that conventional H2-/CO2-dependent homoacetogenesis is thermodynamically unfavorable in situ due to picomolar CO2 levels. Through metagenomics and thermodynamics, we discover unique taxa capable of metabolism adapted to the habitat. This included a novel deep-branching phylum, "Ca. Lithoacetigenota", that exclusively inhabits Hadean analogues and harbors genes encoding alternative modes of H2-utilizing lithotrophy. Rather than CO2, these metabolisms utilize reduced carbon compounds detected in situ presumably serpentinization-derived: formate and glycine. The former employs a partial homoacetogenesis pathway and the latter a distinct pathway mediated by a rare selenoprotein - the glycine reductase. A survey of serpentinite-hosted system microbiomes shows that glycine reductases are diverse and nearly ubiquitous in Hadean analogues. "Ca. Lithoacetigenota" glycine reductases represent a basal lineage, suggesting that catabolic glycine reduction is an ancient bacterial innovation for gaining energy from geogenic H2 even under serpentinization-associated hyperalkaline, CO2-poor conditions. This draws remarkable parallels with ancestral archaeal H2-driven methyl-reducing methanogenesis recently proposed. Unique non-CO2-reducing metabolic strategies presented here may provide a new view into metabolisms that supported primordial life and the diversification of LUCA towards Archaea and Bacteria.

Cys359 of GrdD is the active-site thiol that catalyses the final step of acetyl phosphate formation by glycine reductase from Eubacterium acidaminophilum

2001 ◽  
Vol 268 (24) ◽  
pp. 6417-6425 ◽  
Author(s):  
Ulf-Martin Kohlstock ◽  
Karl Peter Rücknagel ◽  
Michael Reuter ◽  
Angelika Schierhorn ◽  
Jan R. Andreesen ◽  
...  
Keyword(s):  
Active Site ◽  
Acetyl Phosphate ◽  
Glycine Reductase
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