scholarly journals Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet cell autoantibody

Diabetologia ◽  
1990 ◽  
Vol 33 (9) ◽  
pp. 569-572 ◽  
Author(s):  
C. Y. Pak ◽  
C. Y. Cha ◽  
R. V. Rajotte ◽  
R. G. McArthur ◽  
J. W. Yoon
Keyword(s):  
Pancreatic Islet ◽  
Islet Cell ◽  
Pancreatic Islet Cell ◽  
Human Pancreatic Islet ◽  
Islet Cell Autoantibody

Frequent loss of heterozygosity at chromosome 3p14.2-3p21 in human pancreatic islet cell tumours

1999 ◽  
Vol 51 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Marina N. Nikiforova ◽  
Yuri E. Nikiforov ◽  
Paul Biddinger ◽  
Douglas R. Gnepp ◽  
Luis A. Grosembacher ◽  
...  
Keyword(s):  
Loss Of Heterozygosity ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Pancreatic Islet Cell ◽  
Human Pancreatic Islet ◽  
Islet Cell Tumours

Secretion of neurotensin from a human pancreatic islet cell carcinoma cell line (QGP-1N)

1993 ◽  
Vol 49 (2) ◽  
pp. 119-123 ◽  
Author(s):  
Kayoko Tateishi ◽  
Akihiro Funakoshi ◽  
Noboru Kitayama ◽  
Yuji Matsuoka
Keyword(s):  
Cell Carcinoma ◽  
Cell Line ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Pancreatic Islet Cell ◽  
Human Pancreatic Islet ◽  
Islet Cell Carcinoma

SPECIFIC HUMAN PANCREATIC ISLET CELL PROTEINS RECOGNIZED BY ANTIBODIES IN DIABETIC CHILDREN

1982 ◽  
Vol 392 (1 Immunological) ◽  
pp. 378-378
Author(s):  
Steinunn Baekkeskov ◽  
Takahiro Kanatsuna ◽  
Jens H. Nielsen ◽  
Birgitte Marner ◽  
Åke Lernmark
Keyword(s):  
Pancreatic Islet ◽  
Islet Cell ◽  
Pancreatic Islet Cell ◽  
Human Pancreatic Islet ◽  
Diabetic Children

scholarly journals Single‐cell transcriptomes reveal characteristic features of human pancreatic islet cell types

EMBO Reports ◽  
2015 ◽  
Vol 17 (2) ◽  
pp. 178-187 ◽  
Author(s):  
Jin Li ◽  
Johanna Klughammer ◽  
Matthias Farlik ◽  
Thomas Penz ◽  
Andreas Spittler ◽  
...  
Keyword(s):  
Single Cell ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Cell Types ◽  
Pancreatic Islet Cell ◽  
Human Pancreatic Islet ◽  
Characteristic Features ◽  
Islet Cell Types

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

Nature ◽  
1982 ◽  
Vol 298 (5870) ◽  
pp. 167-169 ◽  
Author(s):  
Steinunn Baekkeskov ◽  
Jens Høiriis Nielsen ◽  
Birgitte Marner ◽  
Torben Bilde ◽  
Johnny Ludvigsson ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Islet Cell ◽  
Newly Diagnosed ◽  
Pancreatic Islet Cell ◽  
Human Pancreatic Islet ◽  
Diabetic Children

scholarly journals Erastin-induced ferroptosis is a regulator for the growth and function of human pancreatic islet-like cell clusters

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Xing Yu Li ◽  
Po Sing Leung
Keyword(s):  
Cell Death ◽  
Cell Viability ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Diabetic Patients ◽  
Dependent Manner ◽  
Pancreatic Islet Cell ◽  
Human Pancreatic Islet ◽  
Cell Clusters ◽  
And Function

AbstractFerroptosis is a newly identified and novel form of cell death, which is characterized by an iron- and reactive oxygen species (ROS)-dependent manner. Potential utility of ferroptotic cell death has been recently proposed for cancer treatment. Meanwhile, ROS generation and apoptosis are inherently consequent to cell apoptosis and dysfunction during islet cell preparation and transplantation. Whether ferroptosis induction is a regulator for cell viability and function in human pancreatic islet-cell clusters (ICCs) derived from pancreatic progenitor cells (PPCs) remains elusive. We thus sought to induce ferroptosis in our established cell culture system of human PPCs/ICCs, examine the effects of ferroptosis on ICCs, and explore the potential regulatory pathways involved. Our results showed that ICCs were prone to the use of ferroptosis-inducing and inhibiting agents under our culture conditions. Erastin, a ferroptosis inducer, was found to trigger ferroptosis in ICCs, without the apparent detection of other types of cell death involved, such as apoptosis and autophagy. In corroboration, the use of ferroptosis inhibitor, ferrostatin-1 (Fer-1), was found to enhance the cell viability of ICCs and prevent them from ferroptosis as well as improve its function. Mechanistically, the erastin-induced ferroptosis in ICCs was probably mediated via activation of JNK/P38/MAPK pathways and upregulation of NOX4 expression. Together, our findings may provide a scientific basis of ferroptosis inhibition as a potential for the amelioration of ICC survival and functionality during islet transplantation in diabetic patients.

Beneficial effects of prolactin and laminin on human pancreatic islet-cell cultures

2007 ◽  
Vol 263 (1-2) ◽  
pp. 120-133 ◽  
Author(s):  
Leticia Labriola ◽  
Wagner R. Montor ◽  
Karin Krogh ◽  
Fernando H. Lojudice ◽  
Tércio Genzini ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Cell Cultures ◽  
Islet Cell ◽  
Pancreatic Islet Cell ◽  
Human Pancreatic Islet ◽  
Beneficial Effects
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