scholarly journals Prolonged exposure of pancreatic islets isolated from ?pre-diabetic? non-obese diabetic mice to a high glucose concentration does not impair Beta-cell function

Diabetologia ◽  
1991 ◽  
Vol 34 (1) ◽  
pp. 6-11 ◽  
Author(s):  
D. L. Eizirik ◽  
E. Strandell ◽  
S. Sandler
Keyword(s):  
Beta Cell ◽  
Pancreatic Islets ◽  
High Glucose ◽  
Glucose Concentration ◽  
Beta Cell Function ◽  
Prolonged Exposure ◽  
Cell Function ◽  
High Glucose Concentration ◽  
Diabetic Mice

Metabolism and β-cell function of rat pancreatic islets exposed to human interleukin-1β in the presence of a high glucose concentration

1990 ◽  
Vol 26 (3) ◽  
pp. 245-251 ◽  
Author(s):  
Stellan Sandler ◽  
Klaus Bendtzen ◽  
Décio L. Eizirik ◽  
Eva Strandell ◽  
Michael Welsh ◽  
...  
Keyword(s):  
Pancreatic Islets ◽  
High Glucose ◽  
Glucose Concentration ◽  
Cell Function ◽  
Interleukin 1Β ◽  
High Glucose Concentration ◽  
Β Cell ◽  
Rat Pancreatic Islets ◽  
Β Cell Function

scholarly journals High Glucose Concentration Promotes Vancomycin-Enhanced Biofilm Formation of Vancomycin-Non-Susceptible Staphylococcus aureus in Diabetic Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0134852 ◽  
Author(s):  
Chi-Yu Hsu ◽  
Jwu-Ching Shu ◽  
Mei-Hui Lin ◽  
Kowit-Yu Chong ◽  
Chien-Cheng Chen ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
High Glucose ◽  
Glucose Concentration ◽  
Biofilm Formation ◽  
High Glucose Concentration ◽  
Diabetic Mice

scholarly journals Class IIa HDACs do not influence beta-cell function under normal or high glucose conditions

Islets ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 112-118
Author(s):  
Jacob McCann ◽  
Megan Ellis ◽  
Sean L. McGee ◽  
Kathryn Aston-Mourney
Keyword(s):  
Beta Cell ◽  
High Glucose ◽  
Beta Cell Function ◽  
Cell Function ◽  
Class Iia Hdacs

scholarly journals Pancreatic islets of bank vole show signs of dysfunction after prolonged exposure to high glucose concentrations in vitro

2010 ◽  
Vol 206 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Martin Blixt ◽  
Bo Niklasson ◽  
Stellan Sandler
Keyword(s):  
Gender Difference ◽  
Pancreatic Islets ◽  
High Glucose ◽  
Prolonged Exposure ◽  
Cell Function ◽  
Insulin Biosynthesis ◽  
Bank Voles ◽  
Glucose Tolerant ◽  
Β Cell Function

Bank voles develop glucose intolerance/diabetes mellitus when kept in captivity. We have characterized β-cell function of glucose intolerant/diabetic animals, and found that this animal model has features of both human type 1 and type 2 diabetes. The aim of this study was to study the functional alterations of islets isolated from glucose tolerant bank voles after a prolonged exposure to various glucose concentrations in vitro. For this purpose, pancreatic islets from normal (glucose tolerant) male and female bank voles were cultured at different glucose concentrations (5.6, 11.1 (control), or 28 mM) whereupon islet functions were examined. Overall, islet insulin output was lowered at 5.6 mM glucose, and similar to control, or enhanced after culture in 28 mM glucose. High glucose culture led to decreased insulin contents, but there was no change in islet DNA content and in morphological assessments of cell death, with the latter findings suggesting that the so-called glucotoxicity had not evolved. A slight gender difference was observed in that islets isolated from females exhibited a glucose-regulated (pro)insulin biosynthesis rate and insulin gene expression. In conclusion, we have found that islets isolated from female and male bank voles are affected by glucose concentrations in vitro in that some signs of dysfunction were observed upon high glucose exposure. A minor gender difference was observed suggesting that the islets of the females may more readily adapt to the elevated glucose concentration than islets of the male bank voles. It could be that these in vitro gender differences observed may represent a mechanism underlying the gender difference in diabetes development observed among bank voles.

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