Experiments on the efficacy and toxicity of locoregional chemotherapy of liver tumors with 5-fluoro-2?-deoxyuridine (FUDR) and 5-fluorouracil (5-FU) in an animal model

1986 ◽  
Vol 111 (1) ◽  
pp. 42-46 ◽  
Author(s):  
R. Bartkowski ◽  
M. R. Berger ◽  
J. L. A. Aguiar ◽  
T. H. Henne ◽  
J. D�rsam ◽  
...  
Keyword(s):  
Animal Model ◽  
Liver Tumors ◽  
Locoregional Chemotherapy

scholarly journals Unintended Thermal Injuries from Radiofrequency Ablation: Organ Protection with an Angioplasty Balloon Catheter in an Animal Model

2014 ◽  
Vol 4 ◽  
pp. 1 ◽  
Author(s):  
Martha-Grace Knuttinen ◽  
Thuong G. Van Ha ◽  
Christopher Reilly ◽  
Anthony Montag ◽  
Christopher Straus
Keyword(s):  
Animal Model ◽  
Radiofrequency Ablation ◽  
Liver Tumors ◽  
Balloon Catheter ◽  
Bowel Injury ◽  
Protective Device ◽  
Organ Protection ◽  
Institutional Review ◽  
Novel Approach ◽  
Hepatic Ablation

Objectives: The aim of this study was to investigate a novel approach of using a balloon catheter as a protective device to separate liver from the diaphragm or nearby bowel during radiofrequency ablation (RFA) of hepatic dome tumors in an animal model. Materials and Methods: All experimental procedures were approved by animal Institutional Review Board. Using a 3 cm RF needle electrode, 70 hepatic ablation zones were created using ultrasound in 7 pigs. 50 lesions were created using balloon interposition between liver and diaphragm; 20 lesions were created using the balloon device interposed posteriorly between liver and bowel. Additional 21 control lesions were performed. Animals were sacrificed immediately; diaphragm and bowel were then visually inspected and sectioned. Diaphragmatic and bowel injury was then classified according to the depth of thickness. Results: Control lesions caused full thickness injury, either to diaphragm or bowel. During ablation of lesions with balloon interposition, there was significantly less diaphragmatic injury, P < 0.001 and less bowel injury, P < 0.01. Conclusion: Using balloon interposition as a protective device has advantages over previous saline infusion or CO2 insufflation, providing a safe way to expand percutaneous RFA of liver tumors located on the undersurface of the diaphragm. In addition, this method may be used in protection of other organs adjacent to areas being ablated.

MR and CT imaging of ethanol-treated liver tumors in an animal model

1991 ◽  
Vol 9 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Jeffrey J. Phillips ◽  
Stanley L. Chang ◽  
Hernan I. Vargas ◽  
Paul S. Dickman ◽  
John A. Butler ◽  
...  
Keyword(s):  
Animal Model ◽  
Liver Tumors ◽  
Ct Imaging

scholarly journals Accuracy of ultrasound for detecting liver metastasis xenografts in nude mice

2019 ◽  
Vol 8 (8) ◽  
pp. e20881181
Author(s):  
Caroline Correa de Tullio Augusto Roque ◽  
Eduardo Nóbrega Pereira Lima ◽  
Rubens Chojniak ◽  
Bruno de Tullio Augusto Roque Lima ◽  
Tiago Goss dos Santos
Keyword(s):  
Animal Model ◽  
Liver Metastasis ◽  
Ultrasound Imaging ◽  
Nude Mice ◽  
Liver Tumors ◽  
Liver Parenchyma ◽  
Noninvasive Method ◽  
Ultrasound Findings ◽  
Nodular Lesions ◽  
Viable Method

Nude mice are the usual animal model for studying orthotopically implanted human tumors, and ultrasound imaging has emerged as a viable method for measuring tumors implanted orthotopically. The aim of this study was to evaluate ultrasound findings of liver tumors implanted into mice using a 13-MHz transducer and to correlate these findings with gross pathology and histological examinations. Tumor samples from liver metastases were obtained surgically from patients, and 1-mm³ fragments were implanted into the liver parenchyma of 38 nude mice. Mice were imaged monthly by ultrasound until sacrifice. Of the 38 mice implanted with tumor fragments, 11 developed tumors. Ultrasound detected nodular lesions in the 11 macroscopically positive animals and was able to identify the features of the engrafted tumors. Ultrasound imaging is a viable and noninvasive method for evaluating the liver parenchyma of nude mice, and showed 100% sensitivity and specificity in detecting and characterizing lesions.

Ultrastructural investigation of spontaneous pituitary gonadotroph cell adenomas in aging Sprague-Dawley rats

1983 ◽  
Vol 41 ◽  
pp. 702-703
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Electron Microscopy ◽  
Animal Model ◽  
Epoxy Resin ◽  
Immunoelectron Microscopy ◽  
Tumor Type ◽  
Gonadal Function ◽  
Sprague Dawley ◽  
Male And Female ◽  
Reticulin Fibers ◽  
Sprague Dawley Rats

Gonadotroph cell adenomas of the pituitary are infrequent in human patients and are not invariably associated with altered gonadal function. To date, no animal model of this tumor type exists. Herein, we describe spontaneous gonadotroph cell adenomas in old male and female Sprague-Dawley rats by histology, immunocytology and electron microscopy.The material consisted of the pituitaries of 27 male and 38 female Sprague Dawley rats, all 26 months of age or older, removed at routine autopsy. Sections of formal in-fixed, paraffin-embedded tissue were stained with hematoxylin-phloxine-saffron (HPS), the PAS method and the Gordon-Sweet technique for the demonstration of reticulin fibers. For immunostaining, sections were exposed to anti-rat β-LH, anti-ratβ-TSH, anti-rat PRL, anti-rat GH and anti-rat ACTH 1-39. For electron microscopy, tissue was fixed in 2.5% glutaraldehyde, postfixed in 1% OsO4 and embedded in epoxy-resin. Tissue fixed in 10% formalin, embedded in epoxy resin without osmification, was used for immunoelectron microscopy.

Electron Microscopic Detection and Characterization of Nonhuman Primate Enteric Viruses

1982 ◽  
Vol 40 ◽  
pp. 306-307
Author(s):  
G. C. Smith ◽  
R. L. Heberling ◽  
S. S. Kalter
Keyword(s):  
Electron Microscopy ◽  
Animal Model ◽  
Nonhuman Primate ◽  
Clinical Condition ◽  
Intestinal Tract ◽  
Enteric Viruses ◽  
Electron Microscopic ◽  
Microscopic Detection

A number of viral agents are recognized as and suspected of causing the clinical condition “gastroenteritis.” In our attempts to establish an animal model for studies of this entity, we have been examining the nonhuman primate to ascertain what viruses may be found in the intestinal tract of “normal” animals as well as animals with diarrhea. Several virus types including coronavirus, adenovirus, herpesvirus, and picornavirus (Table I) were detected in our colony; however, rotavirus, astrovirus, and calicivirus have not yet been observed. Fecal specimens were prepared for electron microscopy by procedures reported previously.

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