Antitumor activity of a nitrosourea derivative, CNUA, on murine tumors

1984 ◽  
Vol 13 (1) ◽  
pp. 22-26 ◽  
Author(s):  
Ken-ichi Edanami ◽  
Kanki Komiyama ◽  
Toshio Kuroda ◽  
Iwao Umezawa
Keyword(s):  
Antitumor Activity ◽  
Murine Tumors

scholarly journals Antitumor Activity of the Carboplatin-α-Cyclodextrin Adduct

1997 ◽  
Vol 4 (6) ◽  
pp. 305-306
Author(s):  
Weiping Liu ◽  
Huizhou Xiong ◽  
Yikun Yang ◽  
Ling Li ◽  
Zhiqiang Shen ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Ehrlich Ascites Carcinoma ◽  
Antitumor Efficacy ◽  
Sarcoma 180 ◽  
Murine Tumors ◽  
Ehrlich Ascites

Antitumor activity of the adduct between Carboplatin and α-cyclodextrin has been tested against Sarcoma 180 (S180) and Ehrlich ascites carcinoma (EAC) murine tumors. The preliminary toxicity has also been evaluated by histological examinations of the treated animals. The results show the adduct has less antitumor efficacy than and similar toxicity to Carboplatin.

scholarly journals Antitumor activity of trienomycin A on murine tumors.

1987 ◽  
Vol 40 (12) ◽  
pp. 1768-1772 ◽  
Author(s):  
KANKI KOMIYAMA ◽  
YUMIKO HIROKAWA ◽  
HIROKO YAMAGUCHI ◽  
SHINJI FUNAYAMA ◽  
KAZUAKI MASUDA ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Murine Tumors ◽  
Trienomycin A

scholarly journals Antitumor activity of a new camptothecin derivative, SN-22, against various murine tumors.

1987 ◽  
Vol 10 (3) ◽  
pp. 148-151 ◽  
Author(s):  
TAKEHIKO KUNIMOTO ◽  
KAZUO NITTA ◽  
TOMIKO TANAKA ◽  
NOBUAKI UEHARA ◽  
HIROYASU BABA ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Murine Tumors

Antitumor activity on murine tumors of a novel antitumor benzoylphenylurea derivative, HO-221

1991 ◽  
Vol 28 (5) ◽  
pp. 351-356 ◽  
Author(s):  
Tsunetaka Nakajima ◽  
Hirotoshi Masuda ◽  
Tadao Okamoto ◽  
Masahiro Watanabe ◽  
Kazumasa Yokoyama ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Murine Tumors

scholarly journals Antitumor activity of ormustine against transplantable solid murine tumors. Part I

2017 ◽  
Vol 16 (4) ◽  
pp. 55-60 ◽  
Author(s):  
N. S. Saprykina ◽  
L. M. Borisova ◽  
M. P. Kiseleva ◽  
V. P. Krasnov ◽  
G. L. Levit ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Antitumor Effect ◽  
Antitumor Agents ◽  
Tumor Growth Inhibition ◽  
Lewis Lung ◽  
Reference Drug ◽  
Murine Tumors ◽  
Melanoma B16

Background. Drugs of nitrosourea class are actively and successfully administered in oncology practice. However, at present, the search for new antitumor agents of this class is very urgent. Objective: to examine in vivo antitumor activity of ormustine, a new Russian drug from alkylnitrosourea class, against solid transplantable murine tumors: melanoma B16 and epidermoid Lewis lung carcinoma. Materials and methods. The assessment of antitumor activity of ormustine and a reference drug mustophoran (Les Labolatories Servier, France) was carried out in B6D2F1 mice. Ormustine was administered intravenously at a single dose of 50-135 mg/kg. Mustophoran was administered intravenously at a dose of 32 mg/kg twice (on days 2 and 9) and 3 times at a dose of 25 mg/kg (on days 2, 6 and 9). The follow-up period lasted till the death of animals. The antitumor effect of agents was assessed by the tumor growth inhibition and increase in life span of experimental mice compared to control animals. Results. It has been defined that the single intravenous dose of ormustine (125 mg/kg) is therapeutic for mice bearing melanoma B16 and epidermoid Lewis lung carcinoma. Conclusions. Ormustine possesses high antitumor effect against solid transplantable murine tumors. Ormustine is not inferior to mustophoran in the therapeutic effect against melanoma B16.

scholarly journals Antitumor Activity of a Novel Nucleotide Derivative, 5'-(1,2-Dipalmitoyl-sn-glycero-3-phospho)-5-fluorouridine (TJ14026) on Murine Tumors.

1993 ◽  
Vol 16 (8) ◽  
pp. 778-781 ◽  
Author(s):  
Masahiko HAYASHI ◽  
Hiromichi ITOH ◽  
Takehiko KOSHIO ◽  
Keiji NAKAGAMI ◽  
Kanki KOMIYAMA
Keyword(s):  
Antitumor Activity ◽  
Murine Tumors ◽  
Nucleotide Derivative

710: TNF-Related Apoptosis Inducing Ligand (TRAIL/APO-2L): A Novel Mechanism for BCG-Induced Antitumor Activity

2004 ◽  
Vol 171 (4S) ◽  
pp. 188-189
Author(s):  
Aaron T. Ludwig ◽  
Jill M. Moore ◽  
Yi Luo ◽  
Xiaohong Chen ◽  
Michael A. O’Donnell ◽  
...  
Keyword(s):  
Antitumor Activity

Antitumor activity of tricin, a flavone isolated from leaves of Casearia arborea (Salicaceae)

2017 ◽  
Author(s):  
P Sartorelli ◽  
A Santos ◽  
C Figueiredo ◽  
J Lago ◽  
M Soares
Keyword(s):  
Antitumor Activity
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