scholarly journals Towards continuous glucose monitoring: in vivo evaluation of a miniaturized glucose sensor implanted for several days in rat subcutaneous tissue

Diabetologia ◽  
1992 ◽  
Vol 35 (3) ◽  
pp. 224-230 ◽  
Author(s):  
D. Moatti-Sirat ◽  
F. Capron ◽  
V. Poitout ◽  
G. Reach ◽  
D. S. Bindra ◽  
...  
Keyword(s):  
Continuous Glucose Monitoring ◽  
Glucose Sensor ◽  
Subcutaneous Tissue ◽  
Glucose Monitoring ◽  
In Vivo Evaluation

In Vitro Evaluation of Miniaturized Amperometric Enzyme Sensor Based on the Direct Electron Transfer Principle for Continuous Glucose Monitoring

2022 ◽  
pp. 193229682110706
Author(s):  
Yutaro Inoue ◽  
Yasuhide Kusaka ◽  
Kotaro Shinozaki ◽  
Inyoung Lee ◽  
Koji Sode
Keyword(s):  
Electron Transfer ◽  
Continuous Glucose Monitoring ◽  
Glucose Sensor ◽  
Direct Electron Transfer ◽  
Glucose Dehydrogenase ◽  
Glucose Monitoring ◽  
Reference Electrode ◽  
Enzyme Sensor

Background: The bacterial derived flavin adenine dinucleotide (FAD)-dependent glucose dehydrogenase (FADGDH) is the most promising enzyme for the third-generation principle-based enzyme sensor for continuous glucose monitoring (CGM). Due to the ability of the enzyme to transfer electrons directly to the electrode, recognized as direct electron transfer (DET)-type FADGDH, although no investigation has been reported about DET-type FADGDH employed on a miniaturized integrated electrode. Methods: The miniaturized integrated electrode was formed by sputtering gold (Au) onto a flexible film with 0.1 mm in thickness and divided into 3 parts. After an insulation layer was laminated, 3 openings for a working electrode, a counter electrode and a reference electrode were formed by dry etching. A reagent mix containing 1.2 × 10−4 Unit of DET-type FADGDH and carbon particles was deposited. The long-term stability of sensor was evaluated by continuous operation, and its performance was also evaluated in the presence of acetaminophen and the change in oxygen partial pressure (pO2) level. Results: The amperometric response of the sensor showed a linear response to glucose concentration up to 500 mg/dL without significant change of the response over an 11-day continuous measurement. Moreover, the effect of acetaminophen and pO2 on the response were negligible. Conclusions: These results indicate the superb potential of the DET-type FADGDH-based sensor with the combination of a miniaturized integrated electrode. Thus, the described miniaturized DET-type glucose sensor for CGM will be a promising tool for effective glycemic control. This will be further investigated using an in vivo study.

In vivo evaluation of an electroenzymatic glucose sensor implanted in subcutaneous tissue

1992 ◽  
Vol 7 (10) ◽  
pp. 709-714 ◽  
Author(s):  
K.W. Johnson ◽  
J.J. Mastrototaro ◽  
D.C. Howey ◽  
R.L. Brunelle ◽  
P.L. Burden-Brady ◽  
...  
Keyword(s):  
Glucose Sensor ◽  
Subcutaneous Tissue ◽  
In Vivo Evaluation

scholarly journals Basement Membrane-Based Glucose Sensor Coatings Enhance Continuous Glucose Monitoring in Vivo

2015 ◽  
Vol 9 (5) ◽  
pp. 957-965 ◽  
Author(s):  
Ulrike Klueh ◽  
Yi Qiao ◽  
Caroline Czajkowski ◽  
Izabela Ludzinska ◽  
Omar Antar ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Continuous Glucose Monitoring ◽  
Glucose Sensor ◽  
Glucose Monitoring

In vivo evaluation of a chip based near infrared sensor for continuous glucose monitoring

2014 ◽  
Vol 53 ◽  
pp. 99-104 ◽  
Author(s):  
Lhoucine Ben Mohammadi ◽  
Thomas Klotzbuecher ◽  
Susanne Sigloch ◽  
Knut Welzel ◽  
Michael Göddel ◽  
...  
Keyword(s):  
Continuous Glucose Monitoring ◽  
Near Infrared ◽  
Glucose Monitoring ◽  
Infrared Sensor ◽  
In Vivo Evaluation

In vivo Evaluation of an Electroenzymatic Glucose Sensor Implanted in Subcutaneous Tissue

1992 ◽  
pp. 135-141
Author(s):  
K.W. Johnson ◽  
J.J. Mastrototaro ◽  
D.C. Howey ◽  
R.L. Brunelle ◽  
P.L. Burden-Brady ◽  
...  
Keyword(s):  
Glucose Sensor ◽  
Subcutaneous Tissue ◽  
In Vivo Evaluation

scholarly journals Hydrogel Glucose Sensor with In Vivo Stable Fluorescence Intensity Relying on Antioxidant Enzymes for Continuous Glucose Monitoring

iScience ◽  
2020 ◽  
Vol 23 (6) ◽  
pp. 101243 ◽  
Author(s):  
Jun Sawayama ◽  
Teru Okitsu ◽  
Akihiro Nakamata ◽  
Yoshihiro Kawahara ◽  
Shoji Takeuchi
Keyword(s):  
Antioxidant Enzymes ◽  
Continuous Glucose Monitoring ◽  
Fluorescence Intensity ◽  
Glucose Sensor ◽  
Glucose Monitoring

scholarly journals The effects of three month long continuous glucose monitoring in children with type 1 diabetes on multiple daily insulin injections

2018 ◽  
Vol 75 (12) ◽  
pp. 1209-1215
Author(s):  
Gordana Bukara-Radujkovic ◽  
Vesna Miljkovic ◽  
Sinisa Lakic
Keyword(s):  
Type 1 Diabetes ◽  
Metabolic Control ◽  
Continuous Glucose Monitoring ◽  
Glucose Sensor ◽  
Subcutaneous Tissue ◽  
Glucose Monitoring ◽  
Measurement Information ◽  
Daily Insulin ◽  
Multiple Daily Insulin Injections

Background/Aim. The Professional System of Continuous Glucose Monitoring, the iPro?2 CGM System (Medtronic) is designed to be worn together with a glucose sensor with an electrode inserted into the subcutaneous tissue, up to 7 days, without insight into the current level of glycemia. After reading data from the iPro?2 device, a realistic picture of the glycemia movement during the period of wearing the device is obtained. The aim of the study was to examine whether objective measurement information collected through the use of professional continuous glucose monitoring (CGM) contribute to improved metabolic control in children with type 1 diabetes mellitus who are on the multiple daily insulin injections (MDI). Methods. The study was conducted on 24 patients (14 girls) aged 5 to 18 years, with an average age 12 ? 3.3 years, in the period from June to December 2016 in the Clinic of Pediatrics, University Clinical Center of the Republic of Srpska in Banja Luka. Glycated hemoglobin (HbA1c) was measured in the laboratory at the start of the trial and 3 months afterwards in order to determine the effect of wearing professional iPro?2 on metabolic control, and then three months later, to test for the long-lasting effects in the absence of iPro?2 monitoring. Results. The initial HbA1c was 7.78 ? 1.17% (min: 5.50%; max: 10.00%). After 3 months, HbA1c showed a statistically significant decrease to 7.34 ? 0.84% (min: 5.60%, max: 8.90%). At the six-month follow-up visit, without implementing professional CGM in the meantime, a significant increase in HbA1c was reached, with the average value of 7.68% ? 0.83% (min: 5.50%, max: 9.10%). Conclusion. This study shows that carrying a professional CGM for 7 days per month, 3 months continuously is associated with certain improvement of metabolic control in children with diabetes who are on MDI without increasing risks of hypoglicemia.

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