scholarly journals Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta

Diabetologia ◽  
1995 ◽  
Vol 38 (12) ◽  
pp. 1475-1478 ◽  
Author(s):  
A. Keegan ◽  
H. Walbank ◽  
M. A. Cotter ◽  
N. E. Cameron
Keyword(s):  
Vitamin E ◽  
Rat Aorta ◽  
Diabetic Rat ◽  
Endothelium Dependent Relaxation

scholarly journals Tocotrienol Rich Palm Oil Extract Is More Effective Than Pure Tocotrienols at Improving Endothelium-Dependent Relaxation in the Presence of Oxidative Stress

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Saher F. Ali ◽  
Owen L. Woodman
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Endothelial Function ◽  
Xanthine Oxidase ◽  
Palm Oil ◽  
Oxidant Stress ◽  
Rat Aorta ◽  
Isolated Aorta ◽  
Oil Extract ◽  
Endothelium Dependent Relaxation

Oxidative endothelial dysfunction is a critical initiator of vascular disease. Vitamin E is an effective antioxidant but attempts to use it to treat vascular disorders have been disappointing. This study investigated whether tocotrienols, the less abundant components of vitamin E compared to tocopherols, might be more effective at preserving endothelial function. Superoxide generated by hypoxanthine/xanthine oxidase or rat aorta was measured using lucigenin-enhanced chemiluminescence. The effect ofα-tocopherol,α-,δ-, andγ-tocotrienols and a tocotrienol rich palm oil extract (tocomin) on levels of superoxide was assessed. Endothelial function in rat aorta was assessed in the presence of the auto-oxidant pyrogallol. Whilst all of the compounds displayed antioxidant activity, the tocotrienols were more effective when superoxide was produced by hypoxanthine/xanthine oxidase whereas tocomin andα-tocopherol were more effective in the isolated aorta. Tocomin andα-tocopherol restored endothelial function in the presence of oxidant stress butα-,δ-, andγ-tocotrienols were ineffective. The protective effect of tocomin was replicated when the tocotrienols were present with, but not without,α-tocopherol. Tocotrienol rich tocomin is more effective thanα-tocopherol at reducing oxidative stress and restoring endothelium-dependent relaxation in rat aortae and althoughα-,δ-, andγ-tocotrienols effectively scavenged superoxide, they did not improve endothelial function.

scholarly journals Δ9-tetrahydrocannabinol treatment improved endothelium-dependent relaxation on streptozotocin/nicotinamide-induced diabetic rat aorta

2015 ◽  
Vol 102 (1) ◽  
pp. 51-59 ◽  
Author(s):  
A. Altınok ◽  
Z.M. Coşkun ◽  
K. Karaoğlu ◽  
S. Bolkent ◽  
A.G. Akkan ◽  
...  
Keyword(s):  
Rat Aorta ◽  
Diabetic Rat ◽  
Endothelium Dependent Relaxation

Erigeron breviscapus prevents defective endothelium-dependent relaxation in diabetic rat aorta

Life Sciences ◽  
1999 ◽  
Vol 65 (15) ◽  
pp. 1553-1559 ◽  
Author(s):  
Bang-Hao Zhu ◽  
Yong-Yuan Guan ◽  
Hua He ◽  
Mo-Jun Lin
Keyword(s):  
Rat Aorta ◽  
Diabetic Rat ◽  
Erigeron Breviscapus ◽  
Endothelium Dependent Relaxation

scholarly journals Alpha Lipoic Acid Treatment Improved Endothelium-dependent Relaxation in Diabetic Rat Aorta

2011 ◽  
Vol 131 (5) ◽  
pp. 739-744 ◽  
Author(s):  
N. OKUDAN ◽  
K. E. NURULLAHOĞLU ATALIK ◽  
H. GÖKBEL ◽  
A. CANBILEN ◽  
I. KARA
Keyword(s):  
Lipoic Acid ◽  
Acid Treatment ◽  
Rat Aorta ◽  
Diabetic Rat ◽  
Alpha Lipoic Acid ◽  
Endothelium Dependent Relaxation

Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta

1988 ◽  
Vol 255 (4) ◽  
pp. H825-H833 ◽  
Author(s):  
G. M. Pieper ◽  
G. J. Gross
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Nordihydroguaiaretic Acid ◽  
Rat Aorta ◽  
Diabetic Rat ◽  
Lipoxygenase Inhibitor ◽  
Specificity And Sensitivity ◽  
Endothelium Dependent Relaxation ◽  
Generating System ◽  
Selective Impairment

The present experiments were conducted to determine whether endothelium-dependent relaxation is impaired in chronic (10-12 wk), streptozotocin-induced diabetic rat aortas and to determine the specificity and sensitivity of diabetic vasculature to oxygen-derived free radicals. Endothelium-dependent relaxation by acetylcholine and ADP was severely impaired in diabetic rat aorta, whereas endothelium-independent relaxation by nitroglycerin or papaverine was not impaired. Exposure to a free radical-generating system of xanthine plus xanthine oxidase caused a marked and prolonged relaxation in diabetic but not control vessels. Relaxation could not be prevented by the cyclooxygenase inhibitor indomethacin or the lipoxygenase inhibitor nordihydroguaiaretic acid but was attenuated or blocked by catalase. After free radical exposure, aortic rings were washed, reequilibrated, and contracted with a submaximal concentration of norepinephrine. In free radical-exposed vessels, endothelium-dependent relaxation by acetylcholine was reduced by 50% in nondiabetic vessels and abolished in diabetic vessels. Nevertheless, diabetic vessels could still be fully relaxed by nitroglycerin or papaverine. These results suggest selective impairment of endothelium-dependent relaxation in chronic diabetic rat aortas with particular sensitivity to free radical-induced damage.

Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta

1991 ◽  
Vol 261 (4) ◽  
pp. H1086-H1094 ◽  
Author(s):  
Y. Hattori ◽  
H. Kawasaki ◽  
K. Abe ◽  
M. Kanno
Keyword(s):  
Superoxide Dismutase ◽  
Superoxide Anion ◽  
Rat Aorta ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Transient Nature ◽  
Significant Difference ◽  
Time Courses ◽  
And Control ◽  
Endothelium Dependent Relaxation

Experiments were designed to characterize endothelium-dependent relaxation in thoracic aortic rings obtained from streptozotocin-induced diabetic rats. When the degree of the peak relaxation was compared, the endothelium-dependent relaxant responses to acetylcholine, histamine, or ADP in precontracted aortic rings showed that there was no significant difference between diabetic and control vessels. However, the time courses appeared quite different. The endothelium-dependent relaxant responses in diabetic vessels were more transient than those in control vessels. In addition, the rapid fade of the endothelium-dependent responses observed in diabetic vessels was significantly suppressed by pretreatment with superoxide dismutase. Pretreatment with catalase, deferoxamine, allopurinol, or indomethacin did not prevent the rapid fade of the endothelium-dependent relaxation. The endothelium-independent relaxation induced by nitric oxide also faded more quickly in diabetic vessels; this impairment was less pronounced in the presence of superoxide dismutase. These results suggest that the transient nature of the endothelium-dependent relaxation is more marked in diabetic rat aorta as a result of an enhanced accumulation of superoxide anion.

scholarly journals The protective effect of vitamin E and selenium on liver tissue in fructose- induced diabetic rat

2014 ◽  
Vol 12 (2) ◽  
pp. 47-55
Author(s):  
Farangis Ghassemi ◽  
amin Yuosefinasab ◽  
Hossein Kargar Jahromi ◽  
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Liver Tissue ◽  
Diabetic Rat
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