scholarly journals Islet amyloid polypeptide: demonstration of mRNA in human pancreatic islets by in situ hybridization in islets with and without amyloid deposits

Diabetologia ◽  
1993 ◽  
Vol 36 (4) ◽  
pp. 323-328 ◽  
Author(s):  
G. T. Westermark ◽  
L. Christmanson ◽  
G. Terenghi ◽  
J. Permerth ◽  
C. Betsholtz ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Pancreatic Islets ◽  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Human Pancreatic Islets ◽  
Amyloid Deposits

Regulation of Islet Amyloid Polypeptide in Human Pancreatic Islets

Diabetes ◽  
1993 ◽  
Vol 42 (10) ◽  
pp. 1514-1519 ◽  
Author(s):  
A. Novials ◽  
Y. Sarri ◽  
R. Casamitjana ◽  
F. Rivera ◽  
R. Gomis
Keyword(s):  
Pancreatic Islets ◽  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Human Pancreatic Islets

Regulation of islet amyloid polypeptide in human pancreatic islets

Diabetes ◽  
1993 ◽  
Vol 42 (10) ◽  
pp. 1514-1519 ◽  
Author(s):  
A. Novials ◽  
Y. Sarri ◽  
R. Casamitjana ◽  
F. Rivera ◽  
R. Gomis
Keyword(s):  
Pancreatic Islets ◽  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Human Pancreatic Islets

scholarly journals Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation

2017 ◽  
Vol 114 (42) ◽  
pp. 11127-11132 ◽  
Author(s):  
Diana Ribeiro ◽  
Istvan Horvath ◽  
Nikki Heath ◽  
Ryan Hicks ◽  
Anna Forslöw ◽  
...  
Keyword(s):  
Pancreatic Islets ◽  
Extracellular Vesicles ◽  
Islet Amyloid Polypeptide ◽  
Cell Communication ◽  
Human Islet ◽  
Amyloid Formation ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide ◽  
Amyloid Deposits

Extracellular vesicles (EVs) are small vesicles released by cells to aid cell–cell communication and tissue homeostasis. Human islet amyloid polypeptide (IAPP) is the major component of amyloid deposits found in pancreatic islets of patients with type 2 diabetes (T2D). IAPP is secreted in conjunction with insulin from pancreatic β cells to regulate glucose metabolism. Here, using a combination of analytical and biophysical methods in vitro, we tested whether EVs isolated from pancreatic islets of healthy patients and patients with T2D modulate IAPP amyloid formation. We discovered that pancreatic EVs from healthy patients reduce IAPP amyloid formation by peptide scavenging, but T2D pancreatic and human serum EVs have no effect. In accordance with these differential effects, the insulin:C-peptide ratio and lipid composition differ between EVs from healthy pancreas and EVs from T2D pancreas and serum. It appears that healthy pancreatic EVs limit IAPP amyloid formation via direct binding as a tissue-specific control mechanism.

scholarly journals Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets

Diabetologia ◽  
1989 ◽  
Vol 32 (4) ◽  
pp. 240-244 ◽  
Author(s):  
A. Lukinius ◽  
E. Wilander ◽  
G. T. Westermark ◽  
U. Engstr�m ◽  
P. Westermark
Keyword(s):  
B Cell ◽  
Pancreatic Islets ◽  
Secretory Granules ◽  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Human Pancreatic Islets

Photodegradation of porphyrin-bound hIAPP(1–37) fibrils

2020 ◽  
Vol 44 (22) ◽  
pp. 9438-9443
Author(s):  
Yongxiu Song ◽  
Ping Li ◽  
Zhiming Zhang ◽  
Yin Wang ◽  
Zhefei Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pancreatic Islets ◽  
Islet Amyloid Polypeptide ◽  
Human Islet ◽  
Preventive Strategy ◽  
Islet Amyloid ◽  
Amyloid Deposits

Amyloid deposits in pancreatic islets of type 2 diabetes mellitus (T2DM) are mainly comprised of human islet amyloid polypeptide (hIAPP), the degradation of hIAPP fibrils by photoactive porphyrin could be a preventive strategy against T2DM.

Sign in / Sign up

Export Citation Format

Share Document