Determination of the proliferative potential of human brain tumors using the monoclonal antibody Ki-67

1989 ◽  
Vol 115 (2) ◽  
pp. 179-188 ◽  
Author(s):  
Martina Deckert ◽  
Guido Reifenberger ◽  
Wolfgang Wechsler
Keyword(s):  
Monoclonal Antibody ◽  
Brain Tumors ◽  
Human Brain ◽  
Proliferative Potential ◽  
Ki 67 ◽  
Human Brain Tumors

Cell kinetics studies of human brain tumors by in vitro labeling using anti-BUdR monoclonal antibody

1988 ◽  
Vol 69 (3) ◽  
pp. 371-374 ◽  
Author(s):  
Takafumi Nishizaki ◽  
Tetsuji Orita ◽  
Masahide Saiki ◽  
Yasuhiro Furutani ◽  
Hideo Aoki
Keyword(s):  
Monoclonal Antibody ◽  
Brain Tumors ◽  
Human Brain ◽  
Intravenous Infusion ◽  
Reproductive Age ◽  
Proliferative Potential ◽  
Human Brain Tumor ◽  
Human Brain Tumors

✓ Since the development of a specific monoclonal antibody against the thymidine analogue bromodeoxyuridine (BUdR), many investigators have used intravenous infusion of BUdR to estimate the proliferative potential of human brain tumors. However, side effects such as the induction of cell mutation, latent virus promotion, or inhibition of cytodifferentiation cannot be ignored, and thus many workers hesitate to use it in patients, especially those with hepatic disease or of reproductive age. Furthermore, if BUdR remains in the deoxyribonucleic acid of tumor cells after injection, analysis of the effect of chemical and radiation therapy may not be evaluated correctly. In this report, in vitro BUdR labeling with an anti-BUdR antibody is compared with the in vivo methods described by previous authors. This method appears to be useful for determining the S-phase fraction of human brain tumor. It was more rapid, and was simple, safe, and reproducible as compared to the intravenous infusion method.

Growth fraction in human brain tumors defined by the monoclonal antibody Ki-67

1987 ◽  
Vol 74 (2) ◽  
pp. 179-182 ◽  
Author(s):  
F. Giangaspero ◽  
C. Doglioni ◽  
M. T. Rivano ◽  
S. Pileri ◽  
J. Gerdes ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Brain Tumors ◽  
Human Brain ◽  
Growth Fraction ◽  
Ki 67 ◽  
Human Brain Tumors

Determination of glial fibrillary acidic protein (GFAP) in human brain tumors

1978 ◽  
Vol 35 (1) ◽  
pp. 147-155 ◽  
Author(s):  
C.M. Jacque ◽  
C. Vinner ◽  
M. Kujas ◽  
M. Raoul ◽  
J. Racadot ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Glial Fibrillary Acidic Protein ◽  
Human Brain ◽  
Acidic Protein ◽  
Human Brain Tumors

Quantitative studies of monoclonal antibody targeting to disialoganglioside GD2 in human brain tumors

1995 ◽  
Vol 22 (5) ◽  
pp. 419-426 ◽  
Author(s):  
Enud Arbit ◽  
Nai-Kong V. Cheung ◽  
Samuel D. J. Yeh ◽  
Farhad Daghighian ◽  
Jian Ju Zhang ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors ◽  
Quantitative Studies ◽  
Antibody Targeting

scholarly journals EXPRESSION OF ANTIGENS DEFINED BY THE MONOCLONAL ANTIBODY AT5 IN CULTURED NEURAL CELLS AND IN HUMAN BRAIN TUMORS OF GLIAL ORIGIN

1997 ◽  
Vol 18 (1) ◽  
pp. 7-19
Author(s):  
ALEXANDER A. PREOBRAZHENSKY ◽  
FRANCESCA ALOISI ◽  
VALERY M. BARABANOV ◽  
KARL SCHWECHHEIMER
Keyword(s):  
Monoclonal Antibody ◽  
Brain Tumors ◽  
Human Brain ◽  
Neural Cells ◽  
Human Brain Tumors

scholarly journals Monoclonal Antibody to Human Midkine Reveals Increased Midkine Expression in Human Brain Tumors

1999 ◽  
Vol 58 (5) ◽  
pp. 430-441 ◽  
Author(s):  
SHINSUKE KATO ◽  
KENJI ISHIHARA ◽  
TAKAO SHINOZAWA ◽  
HIROYUKI YAMAGUCHI ◽  
YOSHIYA ASANO ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors
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