Identification of a sexual hormone and related substances in the marine brown alga Desmarestia

1982 ◽  
Vol 69 (6) ◽  
pp. 290-291 ◽  
Author(s):  
D. G. M�ller ◽  
A. Peters ◽  
G. Gassmann ◽  
W. Boland ◽  
F. -J. Marner ◽  
...  
Keyword(s):  
Brown Alga ◽  
Sexual Hormone ◽  
Related Substances ◽  
Marine Brown Alga

Effect of the marine brown alga Canistrocarpus cervicornis on promastigote forms of Leishmania (L.) amazonensis

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
AO Santos ◽  
EA Britta ◽  
T Ueda-Nakamura ◽  
BP Dias Filho ◽  
EM Bianco ◽  
...  
Keyword(s):  
Brown Alga ◽  
Canistrocarpus Cervicornis ◽  
Marine Brown Alga

Meroditerpenoids from the southern Australian marine brown alga Sargassum fallax

2009 ◽  
Vol 70 (2) ◽  
pp. 250-255 ◽  
Author(s):  
Priyanka Reddy ◽  
Sylvia Urban
Keyword(s):  
Brown Alga ◽  
Marine Brown Alga

scholarly journals Natural Compounds from the Marine Brown Alga Caulocystis cephalornithos with Potent In Vitro-Activity against the Parasitic Nematode Haemonchus contortus

Pathogens ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 550
Author(s):  
Aya C. Taki ◽  
Robert Brkljača ◽  
Tao Wang ◽  
Anson V. Koehler ◽  
Guangxu Ma ◽  
...  
Keyword(s):  
Haemonchus Contortus ◽  
Brown Alga ◽  
Parasitic Nematode ◽  
Anthelmintic Activity ◽  
Adult Males ◽  
Terrestrial Plants ◽  
Third Stage ◽  
Future Work ◽  
Marine Brown Alga

Eight secondary metabolites (1 to 8) were isolated from a marine sponge, a marine alga and three terrestrial plants collected in Australia and subsequently chemically characterised. Here, these natural product-derived compounds were screened for in vitro-anthelmintic activity against the larvae and adult stages of Haemonchus contortus (barber’s pole worm)—a highly pathogenic parasitic nematode of ruminants. Using an optimised, whole-organism screening system, compounds were tested on exsheathed third-stage larvae (xL3s) and fourth-stage larvae (L4s). Anthelmintic activity was initially evaluated on these stages based on the inhibition of motility, development and/or changes in morphology (phenotype). We identified two compounds, 6-undecylsalicylic acid (3) and 6-tridecylsalicylic acid (4) isolated from the marine brown alga, Caulocystis cephalornithos, with inhibitory effects on xL3 and L4 motility and larval development, and the induction of a “skinny-straight” phenotype. Subsequent testing showed that these two compounds had an acute nematocidal effect (within 1–12 h) on adult males and females of H. contortus. Ultrastructural analysis of adult worms treated with compound 4 revealed significant damage to subcuticular musculature and associated tissues and cellular organelles including mitochondria. In conclusion, the present study has discovered two algal compounds possessing acute anthelmintic effects and with potential for hit-to-lead progression. Future work should focus on undertaking a structure-activity relationship study and on elucidating the mode(s) of action of optimised compounds.

Dolastane and Secodolastane Diterpenes from the Marine Brown Alga, Dictyota cericornis

1986 ◽  
Vol 49 (4) ◽  
pp. 570-575 ◽  
Author(s):  
Valéria Laneuville Teixeira ◽  
Therezinha Tomassini ◽  
Beatriz Grosso Fleury ◽  
Alphonse Kelecom
Keyword(s):  
Brown Alga ◽  
Marine Brown Alga

Synthesis, Structural Revision, and Biological Activities of 4′-Chloroaurone, a Metabolite of Marine Brown Alga Spatoglossum variabile.

ChemInform ◽  
2007 ◽  
Vol 38 (43) ◽  
Author(s):  
Somepalli Venkateswarlu ◽  
Gopala K. Panchagnula ◽  
Aditya L. Gottumukkala ◽  
Gottumukkala V. Subbaraju
Keyword(s):  
Brown Alga ◽  
Biological Activities ◽  
Structural Revision ◽  
Marine Brown Alga
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