A non-Mendelian factor, [eta+], causes lethality of yeast omnipotent-suppressor strains

1984 ◽  
Vol 8 (8) ◽  
pp. 567-573 ◽  
Author(s):  
Susan W. Liebman ◽  
Jamie A. All-Robyn
Keyword(s):  
Mendelian Factor

scholarly journals Isolation of omnipotent suppressors in an [eta+] yeast strain.

Genetics ◽  
1990 ◽  
Vol 124 (3) ◽  
pp. 505-514 ◽  
Author(s):  
J A All-Robyn ◽  
D Kelley-Geraghty ◽  
E Griffin ◽  
N Brown ◽  
S W Liebman
Keyword(s):  
Yeast Strain ◽  
Guanidine Hydrochloride ◽  
Wild Type ◽  
Translational Fidelity ◽  
Genetic Analyses ◽  
Mendelian Factor ◽  
Nonsense Codons

Abstract Omnipotent suppressors decrease translational fidelity and cause misreading of nonsense codons. In the presence of the non-Mendelian factor [eta+], some alleles of previously isolated omnipotent suppressors are lethal. Thus the current search was conducted in an [eta+] strain in an effort to identify new suppressor loci. A new omnipotent suppressor, SUP39, and alleles of sup35, sup45, SUP44 and SUP46 were identified. Efficiencies of the dominant suppressors were dramatically reduced in strains that were cured of non-Mendelian factors by growth on guanidine hydrochloride. Wild-type alleles of SUP44 and SUP46 were cloned and these clones were used to facilitate the genetic analyses. SUP44 was shown to be on chromosome VII linked to cyh2, and SUP46 was clearly identified as distinct from the linked sup45.

scholarly journals LUTEAR CELLS AND HEN-FEATHERING

1918 ◽  
Vol 1 (1) ◽  
pp. 127-131 ◽  
Author(s):  
Alice M. Boring ◽  
T. H. Morgan
Keyword(s):  
Experimental Evidence ◽  
Secretory Cell ◽  
Genetic Factors ◽  
Young Males ◽  
Mendelian Factor ◽  
Male Plumage ◽  
Secondary Sexual

The experimental evidence had made clear that some substance is produced in the testis of the male Sebright that suppresses in him the development of the secondary sexual plumage of the cock of his species. The detection in his testis of lutear cells like those in hens makes the conclusion highly probable that it is these cells that cause the suppression of cock-feathering in both the Sebright male and in hens of all fowls. Genetic work by Morgan had shown that one or two Mendelian factor-differences are responsible for hen-feathering in the Sebright. These factor-differences produce their effects through the testes. The presence of these genetic factors, we now see, causes the testes of the Sebright to produce a kind of secretory cell that is ordinarily only produced in the female, or possibly to a slight extent in young males (Boring), or in numbers insufficient to suppress the male plumage in the testes of some ordinary cock birds (Reeves).

scholarly journals INHERITANCE OF A PAROTID SECRETORY PROTEIN IN MICE AND ITS USE IN DETERMINING SALIVARY AMYLASE QUANTITATIVE VARIANTS

Genetics ◽  
1980 ◽  
Vol 95 (1) ◽  
pp. 129-141
Author(s):  
David Owerbach ◽  
J Peter Hjorth
Keyword(s):  
Cyanogen Bromide ◽  
Inbred Strains ◽  
Secretory Protein ◽  
Major Protein ◽  
Chromosome 2 ◽  
Parotid Glands ◽  
Salivary Amylase ◽  
Inbred Strains Of Mice ◽  
Mendelian Factor ◽  
Parotid Secretory Protein

ABSTRACT Among inbred strains of mice, a major protein, PSP, produced and secreted by the parotid glands, shows variation in electrophoretic mobility and in the peptides produced by cyanogen bromide treatment. This variation is inherited as a single Mendelian factor with two alleles showing co-dominant expression. In genetic crosses, it segregates independently from the amylase complex and is closely linked to the agouti locus on chromosome 2. The protein ratios between amylase and PSP in saliva, obtained by scanning of electrophoretic gel separations, were found to reflect genetic differences in salivary amylase production in strains YBR/Cv and C3H/As.

scholarly journals ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS)

1965 ◽  
Vol 122 (4) ◽  
pp. 673-679 ◽  
Author(s):  
Paul Pinchuck ◽  
Paul H. Maurer
Keyword(s):  
Amino Acids ◽  
Genetic Factor ◽  
Inbred Strains ◽  
Swiss Mice ◽  
Mendelian Factor

The ability of mice to form antibodies against the random terpolymer glu57lys38ala5 is controlled by a codominant Mendelian factor. Three of 7 inbred strains were 100 per cent responders; the others were completely negative. All of these strains could make antibody to related polymers with higher alanine content (10 and 40 mole per cent). Breeding studies using the progeny of Swiss mice indicated that a similar genetic factor was involved.

scholarly journals THE RANDOM PHENOTYPE CONCEPT, WITH APPLICATIONS

Genetics ◽  
1972 ◽  
Vol 72 (4) ◽  
pp. 739-758
Author(s):  
Allan Birnbaum
Keyword(s):  
Probability Distribution ◽  
Factor Models ◽  
Effective Factor ◽  
Special Cases ◽  
Mendelian Factor ◽  
Threshold Characters ◽  
Illustrative Application

ABSTRACT A random phenotype is defined as a probability distribution over any given set of phenotypes. This includes as special cases the kinds of phenotypes usually considered (qualitative, quantitative, and threshold characters) and all others. Correspondingly general methods are indicated for analyzing data of all forms in terms of the classical Mendelian factor concept (as distinct from the biometrical methods usually applied to measurement and graded data, associated with the effective factor concept). These are applied in a new analysis of the data of E. L. Green (1951, 1954, 1962) on skeletal variation in the mouse. The adequacies of various classical one-factor and several-factor models are considered. Indications of an underlying scale are found from this new standpoint. The results are compared with those obtained by Green using the scaling approach. An illustrative application is also made to some of Bruell's (1962) continuous behavioural data on mice. This work was substantially completed in 1959 but not previously prepared for publication. The same approach was originated and developed independently by R. L. Collins who has treated a wider range of theoretical problems (cf. Collins 1967, 1968a, 1969b, 1970c) and a wider range of applications (cf. Collins and Fuller 1968; Collins 1968b, 1969a, 1970a). A less general independent development is that of Mode and Gasser 1972.

Evidence for a Mendelian factor controlling the cytokinin requirement of cultured tobacco cells

1983 ◽  
Vol 4 (2) ◽  
pp. 129-141 ◽  
Author(s):  
Frederick Meins ◽  
Rachel Foster ◽  
Joseph D. Lutz
Keyword(s):  
Tobacco Cells ◽  
Mendelian Factor

scholarly journals Mendelian Factor Differences Versus Reaction System Contrasts in Heredity. II

1917 ◽  
Vol 51 (602) ◽  
pp. 92-101 ◽  
Author(s):  
T. H. Goodspeed ◽  
R. E. Clausen
Keyword(s):  
Reaction System ◽  
Mendelian Factor
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