Size regulation in larvae of the crustacean Balanus eburneus (Cirripedia: Thoracica)

1987 ◽  
Vol 96 (1) ◽  
pp. 47-58 ◽  
Author(s):  
T. L. West ◽  
J. D. Costlow
Keyword(s):  
Size Regulation ◽  
Balanus Eburneus

Lats in Organ Size Regulation and Cancer

2017 ◽  
pp. 2451-2458
Author(s):  
Chiswili Chabu ◽  
Duc Nguyen ◽  
Greg Turenchalkb ◽  
Tian Xu
Keyword(s):  
Organ Size ◽  
Size Regulation

Cell cycle and cell size regulation in Down Syndrome cells

2003 ◽  
pp. 51-58 ◽  
Author(s):  
M. Rosner ◽  
A. Kowalska ◽  
A. Freilinger ◽  
A-R. Prusa ◽  
E. Marton ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Down Syndrome ◽  
Cell Size ◽  
Size Regulation

scholarly journals Breaking the scale: how disrupting the karyoplasmic ratio gives cancer cells an advantage for metastatic invasion

2017 ◽  
Vol 45 (6) ◽  
pp. 1333-1344
Author(s):  
Andrea Rizzotto ◽  
Eric C. Schirmer
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Cancer Cells ◽  
Nuclear Size ◽  
Nuclear Morphology ◽  
Metastatic Tumors ◽  
Size Regulation ◽  
Diagnosis And Prognosis ◽  
Ploidy Changes ◽  
Tumor Types

Nuclear size normally scales with the size of the cell, but in cancer this ‘karyoplasmic ratio’ is disrupted. This is particularly so in more metastatic tumors where changes in the karyoplasmic ratio are used in both diagnosis and prognosis for several tumor types. However, the direction of nuclear size changes differs for particular tumor types: for example in breast cancer, larger nuclear size correlates with increased metastasis, while for lung cancer smaller nuclear size correlates with increased metastasis. Thus, there must be tissue-specific drivers of the nuclear size changes, but proteins thus far linked to nuclear size regulation are widely expressed. Notably, for these tumor types, ploidy changes have been excluded as the basis for nuclear size changes, and so, the increased metastasis is more likely to have a basis in the nuclear morphology change itself. We review what is known about nuclear size regulation and postulate how such nuclear size changes can increase metastasis and why the directionality can differ for particular tumor types.

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