Effects of Growth hormone on rat skeletal muscle after hindlimb suspension

1994 ◽  
Vol 69 (4) ◽  
pp. 337-343 ◽  
Author(s):  
A. X. Bigard ◽  
F. Lienhard ◽  
D. Merino ◽  
B. Serrurier ◽  
C. Y. Guezennec
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Hindlimb Suspension ◽  
Rat Skeletal Muscle

Resistance exercise and growth hormone as countermeasures for skeletal muscle atrophy in hindlimb-suspended rats

1994 ◽  
Vol 267 (2) ◽  
pp. R365-R371 ◽  
Author(s):  
J. K. Linderman ◽  
K. L. Gosselink ◽  
F. W. Booth ◽  
V. R. Mukku ◽  
R. E. Grindeland
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Resistance Exercise ◽  
Protein Content ◽  
Muscle Atrophy ◽  
Myofibrillar Protein ◽  
Hindlimb Suspension ◽  
Skeletal Muscle Atrophy ◽  
Plantar Flexor ◽  
Fast Twitch

Unweighting of rat hindlimb muscles results in skeletal muscle atrophy, decreased protein synthesis, and reduced growth hormone (GH) secretion. Resistance exercise (ladder climbing) and GH treatment partially attenuate skeletal muscle atrophy in hypophysectomized hindlimb-suspended rats. It was hypothesized that a combination of multiple bouts of daily resistance exercise and GH (1 mg.kg-1.day-1) would prevent skeletal muscle atrophy in growing nonhypophysectomized hindlimb-suspended rats. Hindlimb suspension decreased the absolute (mg/pair) and relative (mg/100 g body wt) weights of the soleus, a slow-twitch plantar flexor, by 30 and 21%, respectively, and the absolute and relative weights of the gastrocnemius, a predominantly fast-twitch plantar flexor, by 20 and 11%, respectively (P < 0.05). Exercise did not increase soleus mass but attenuated loss of relative wet weight in the gastrocnemius muscles of hindlimb-suspended rats (P < 0.05). Hindlimb suspension decreased gastrocnemius myofibrillar protein content and synthesis (mg/day) by 26 and 64%, respectively (P < 0.05). The combination of exercise and GH attenuated loss of gastrocnemius myofibrillar protein content and synthesis by 70 and 23%, respectively (P < 0.05). Results of the present investigation indicate that a combination of GH and resistance exercise attenuates atrophy of unweighted fast-twitch skeletal muscles.

scholarly journals The Effects of Hindlimb Suspension on Proteins Essential to Cholesterol Metabolism in Rat Skeletal Muscle

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Teak Veng Lee ◽  
Joshua M Swift ◽  
Vincent CW Chen ◽  
Chang Woock Lee ◽  
Steve Bui ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cholesterol Metabolism ◽  
Hindlimb Suspension ◽  
Rat Skeletal Muscle

Protein turnover in rat skeletal muscle: effects of hypophysectomy and growth hormone.

1978 ◽  
Vol 234 (1) ◽  
pp. E38 ◽  
Author(s):  
K E Flaim ◽  
J B Li ◽  
L S Jefferson
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Protein Synthesis ◽  
Protein Turnover ◽  
Gastrocnemius Muscle ◽  
Growth Hormone Treatment ◽  
Hormone Replacement ◽  
Hormone Treatment ◽  
Rat Skeletal Muscle

The role of growth hormone in regulating protein turnover was examined in a perfused preparation of rat skeletal muscle. The perfused muscle maintained in vivo levels of ATP and creatine phosphate and exhibited constant rates of oxygen consumption and protein synthesis. Hypophysectomy reduced the rate of protein synthesis, the concentration of RNA, and the efficiency of protein synthesis in gastrocnemius muscle to 30, 46, and 66 percent of normal, respectively. In vivo treatment of hypophysectomized (hypox) rats with bovine growth hormone (250 microgram/day for 5 days) resulted in small increases in protein synthesis and RNA, whereas synthesis/RNA was returned to near normal. Elevation of ribosomal subunits in psoas muscle indicated an inhibition of peptide-chain initiation in hypox rats that was reversed by in vivo growth hormone treatment. Thus, hypox rats exhibited both a decreased capacity and a decreased efficiency of protein synthesis. Growth hormone replacement primarily increased efficiency of protein synthesis. The rate of protein degradation and the activity of cathepsin D in gastrocnemius muscle were decreased by hypophysectomy. Growth hormone treatment had no significant effect on degradation.

Effect of Hypophysectomy and Growth Hormone Administration on Myosin Heavy Chains in Rat Skeletal Muscle

2004 ◽  
Vol 36 (Supplement) ◽  
pp. S302
Author(s):  
Daniel A. Judelson ◽  
William J. Kraemer ◽  
Nicholas A. Demonaco ◽  
Barry A. Spiering ◽  
Ricardo Silvestre ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Myosin Heavy Chains ◽  
Rat Skeletal Muscle ◽  
Growth Hormone Administration ◽  
Heavy Chains ◽  
Hormone Administration

Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone

2006 ◽  
Vol 21 (2) ◽  
pp. 372-380 ◽  
Author(s):  
Bodvael Fraysse ◽  
Jean-François Desaphy ◽  
Jean-François Rolland ◽  
Sabata Pierno ◽  
Antonella Liantonio ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Calcium Homeostasis ◽  
Fiber Type ◽  
Rat Skeletal Muscle ◽  
Muscle Calcium
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