Development of reactor model for glucose isomerization catalyzed by whole-cell immobilized glucose isomerase

1991 ◽  
Vol 7 (4) ◽  
pp. 183-187 ◽  
Author(s):  
D. Vasić-Rački ◽  
N. Pavlović ◽  
S. Čižmek ◽  
M. Dražić ◽  
B. Husadžić
Keyword(s):  
Glucose Isomerase ◽  
Reactor Model ◽  
Whole Cell ◽  
Immobilized Glucose Isomerase ◽  
Glucose Isomerization

scholarly journals From a Sequential Chemo-Enzymatic Approach to a Continuous Process for HMF Production from Glucose

Catalysts ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 335 ◽  
Author(s):  
Alexandra Gimbernat ◽  
Marie Guehl ◽  
Nicolas Lopes Ferreira ◽  
Egon Heuson ◽  
Pascal Dhulster ◽  
...  
Keyword(s):  
Organic Liquid ◽  
Continuous Process ◽  
Glucose Isomerase ◽  
Arylboronic Acid ◽  
Catalyst Recycling ◽  
Biomass Valorization ◽  
Fully Integrated ◽  
Immobilized Glucose Isomerase ◽  
Fructose Dehydration ◽  
Glucose Isomerization

Notably available from the cellulose contained in lignocellulosic biomass, glucose is a highly attractive substrate for eco-efficient processes towards high-value chemicals. A recent strategy for biomass valorization consists on combining biocatalysis and chemocatalysis to realise the so-called chemo-enzymatic or hybrid catalysis. Optimisation of the glucose conversion to 5-hydroxymethylfurfural (HMF) is the object of many research efforts. HMF can be produced by chemo-catalyzed fructose dehydration, while fructose can be selectively obtained from enzymatic glucose isomerization. Despite recent advances in HMF production, a fully integrated efficient process remains to be demonstrated. Our innovative approach consists on a continuous process involving enzymatic glucose isomerization, selective arylboronic-acid mediated fructose complexation/transportation, and chemical fructose dehydration to HMF. We designed a novel reactor based on two aqueous phases dynamically connected via an organic liquid membrane, which enabled substantial enhancement of glucose conversion (70%) while avoiding intermediate separation steps. Furthermore, in the as-combined steps, the use of an immobilized glucose isomerase and an acidic resin facilitates catalyst recycling.

D-Glucose Isomerization using an Immobilized Glucose Isomerase preparation from Streptomyces Thermovulgaris Strain 127

1991 ◽  
Vol 11 (1) ◽  
pp. 49-55 ◽  
Author(s):  
S. D. Vlaev ◽  
D. Elenkov ◽  
M. Tsenova ◽  
M. Stoychev ◽  
G. Djejeva
Keyword(s):  
Glucose Isomerase ◽  
Immobilized Glucose Isomerase ◽  
Glucose Isomerization
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