Dose-response relationship for radiation carcinogenesis in the low-dose region

1994 ◽  
Vol 66 (2) ◽  
pp. 71-75 ◽  
Author(s):  
Bernard L. Cohen
Keyword(s):  
Dose Response ◽  
Low Dose ◽  
Response Relationship ◽  
Radiation Carcinogenesis ◽  
Dose Response Relationship

scholarly journals Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Ning Liu ◽  
Yang Peng ◽  
Xinguang Zhong ◽  
Zheng Ma ◽  
Suiping He ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Ionizing Radiation ◽  
Dose Response ◽  
Low Dose ◽  
Linear Trend ◽  
Hematological Parameters ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Spline Models ◽  
Cumulative Radiation Dose

Abstract Background Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. Methods Using a prospective cohort study design, we collected health examination reports and personal dose monitoring data from medical workers and used Poisson regression and restricted cubic spline models to assess the correlation between changing hematological parameters and cumulative radiation dose and determine the dose-response relationship. Results We observed that changing platelet of 1265 medical workers followed up was statistically different among the cumulative dose groups (P = 0.010). Although the linear trend tested was not statistically significant (Ptrend = 0.258), the non-linear trend tested was statistically significant (Pnon-linear = 0.007). Overall, there was a correlation between changing platelets and cumulative radiation dose (a change of βa 0.008 × 109/L during biennially after adjusting for gender, age at baseline, service at baseline, occupation, medical level, and smoking habits; 95% confidence interval [CI] = 0.003,0.014 × 109/L). Moreover, we also found positive first and then negative dose-response relationships between cumulative radiation dose and changing platelets by restricted cubic spline models, while there were negative patterns of the baseline service not less than 10 years (− 0.015 × 109/L, 95% CI = − 0.024, − 0.007 × 109/L) and radiation nurses(− 0.033 × 109/L, 95% CI = − 0.049, − 0.016 × 109/L). Conclusion We concluded that although the exposure dose was below the limit, medical workers exposed to low-dose ionizing radiation for a short period of time might have increased first and then decreased platelets, and there was a dose-response relationship between the cumulative radiation dose and platelets changing.

Defining hormesis: the necessary tool to clarify experimentally the low dose–response relationship

2002 ◽  
Vol 21 (2) ◽  
pp. 103-104 ◽  
Author(s):  
G Carelli ◽  
I Iavicoli
Keyword(s):  
Dose Response ◽  
Low Dose ◽  
Experimental Models ◽  
Assessment Criteria ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Specific Context ◽  
Definition Of ◽  
Time Specific ◽  
Made In

The authors comment on Calabrese and Baldwin's paper ‘Defining Hormesis’, which, to date, is the first attempt to provide a definition of hormesis that goes beyond the different interpretations of this phenomenon reported in the literature. While appreciating the effort made in this study to place hormesis in a general and at the same time specific context, the authors believe some clarifications are needed as regards the quantitative features of this phenomenon. In this connection, they speculate on whether Calabrese and Baldwin think it appropriate to include hormesis assessment criteria in the document, referring in particular to those reported in a previous paper. The authors share Calabrese and Baldwin's conclusion that future experimental models designed to study hormetic phenomena must necessarily include the time factor, which not only guarantees this phenomenon will be detected, but is also able to detect the specific type of hormesis.

scholarly journals Is There a Dose-Response Relationship for Heart Disease With Low-Dose Radiation Therapy?

2013 ◽  
Vol 85 (4) ◽  
pp. 959-964 ◽  
Author(s):  
Eugene Chung ◽  
James R. Corbett ◽  
Jean M. Moran ◽  
Kent A. Griffith ◽  
Robin B. Marsh ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Heart Disease ◽  
Dose Response ◽  
Low Dose ◽  
Response Relationship ◽  
Low Dose Radiation ◽  
Dose Response Relationship ◽  
Dose Radiation

scholarly journals Nonlinear Dose-Response Relationship in the Immune System following Exposure to Ionizing Radiation: Mechanisms and Implications

2003 ◽  
Vol 1 (1) ◽  
pp. 154014203908444 ◽  
Author(s):  
Shu-Zheng Liu
Keyword(s):  
T Lymphocyte ◽  
Dose Response ◽  
Low Dose ◽  
Cell Types ◽  
High Dose ◽  
Response Relationship ◽  
Low Dose Radiation ◽  
Dose Response Relationship ◽  
Dose Radiation ◽  
Different Doses

The health effects of low-dose radiation (LDR) have been the concern of the academic spheres, regulatory bodies, governments, and the public. Among these effects, the most important is carcinogenesis. In view of the importance of immune surveillance in cancer control, the dose-response relationship of the changes in different cell types of the immune system after whole-body irradiation is analyzed on the basis of systemic data from the author's laboratory in combination with recent reports in the literature. For T lymphocytes J- or inverted J-shaped curves are usually demonstrated after irradiation, while for macrophages dose-response curves of chiefly stimulation with irregular patterns are often observed. The intercellular reactions between the antigen presenting cell (APC) and T lymphocyte (TLC) in the immunologic synapse via expression of surface molecules and secretion of cytokines by the two cell types after different doses of radiation are illustrated. The different pathways of signal transduction thus facilitated in the T lymphocyte by different doses of radiation are analyzed to explain the mechanism of the phenomenon of low-dose stimulation and high-dose suppression of immunity. Experimental and clinical data are cited to show that LDR retards tumor growth, reduces metastasis, increases the efficacy of conventional radiotherapy and chemotherapy as well as alleviates the suppression of immunity due to tumor burden. The incidence of thymic lymphoma after high-dose radiation is lowered by preexposure to low-dose radiation, and its mechanism is supposed to be related to the stimulation of anticancer immunity induced by low-dose radiation. Recent reports on lowering of standardized cancer mortality rate and all cause death rate of cohorts occupationally exposed to low-dose radiation from the US, UK, and Canada are cited.

scholarly journals Modulation of Cytochrome P450 2A5 Activity by Lipopolysaccharide: Low-Dose Effects and Non-Monotonic Dose-Response Relationship

PLoS ONE ◽  
2015 ◽  
Vol 10 (1) ◽  
pp. e0117842 ◽  
Author(s):  
Ana C. A. X. De-Oliveira ◽  
Kátia S. Poça ◽  
Paulo R. R. Totino ◽  
Francisco J. R. Paumgartten
Keyword(s):  
Cytochrome P450 ◽  
Dose Response ◽  
Low Dose ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Dose Effects ◽  
Low Dose Effects
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