Urinary vanadium as a biological indicator of exposure to vanadium

1989 ◽  
Vol 61 (4) ◽  
pp. 283-287 ◽  
Author(s):  
Toshio Kawai ◽  
Kazunori Seiji ◽  
Takao Watanabe ◽  
Haruo Nakatsuka ◽  
Masayuki Ikeda
Keyword(s):  
Biological Indicator ◽  
Urinary Vanadium

A Standard Primary Toxicity Bioassay Using Daphnia Magna as a Test Species

1977 ◽  
Vol 12 (1) ◽  
pp. 27-50 ◽  
Author(s):  
L.A. Behie ◽  
J.E. Zajic ◽  
D. Berk ◽  
R.J.P. Brouzes ◽  
V.A. Naish
Keyword(s):  
Statistical Analysis ◽  
Daphnia Magna ◽  
Biological Indicator ◽  
Pulp And Paper ◽  
Toxicity Bioassay ◽  
Simple Method ◽  
Test Species ◽  
Test Organisms ◽  
Dilution Water

Abstract Although Daphnia magna have been widely used in the determination of the toxicity of various substances, there are no reports in the literature that describe a rigorous bioassay method using this organism as a test species. The test described herein involves the standariza-tion of various important aspects of the method such as the age of the test organisms, and the dilution water used for the preparation of the various toxicant concentrations. Also described is a simple method for the statistical analysis of the results. The sensitivity of the proposed bioassay is demonstrated by determining the toxicity of various pulp and paper effluents. Finally, extensive bioassays were carried out simultaneously with rainbow trout and Daphnia magna indicating that Daphnia are as good a biological indicator of acute toxicity as fish.

scholarly journals A Short-Term Biological Indicator for Long-Term Kidney Damage after Radionuclide Therapy in Mice

2017 ◽  
Vol 10 (4) ◽  
pp. 57
Author(s):  
Giovanni Pellegrini ◽  
Klaudia Siwowska ◽  
Stephanie Haller ◽  
Daniel Antoine ◽  
Roger Schibli ◽  
...  
Keyword(s):  
Radionuclide Therapy ◽  
Biological Indicator ◽  
Kidney Damage ◽  
Short Term

scholarly journals Fundamental Investigations on Analytical Methods and Biological Indicator for Monitoring Systems of Environmental Pollutants

1985 ◽  
Vol 26 (6) ◽  
pp. 591-599_1 ◽  
Author(s):  
Takashi KASHIMOTO ◽  
Hideaki MIYATA ◽  
Shigehiko FUKUSHIMA ◽  
Katsuyoshi KUWABARA ◽  
Ryoichi TANAKA
Keyword(s):  
Analytical Methods ◽  
Environmental Pollutants ◽  
Biological Indicator ◽  
Monitoring Systems

Bacteroidetes as a sensitive biological indicator of agricultural soil usage revealed by a culture-independent approach

2017 ◽  
Vol 119 ◽  
pp. 128-137 ◽  
Author(s):  
Agnieszka Wolińska ◽  
Agnieszka Kuźniar ◽  
Urszula Zielenkiewicz ◽  
Dariusz Izak ◽  
Anna Szafranek-Nakonieczna ◽  
...  
Keyword(s):  
Agricultural Soil ◽  
Biological Indicator ◽  
Culture Independent

scholarly journals Degradation of the Retinoblastoma Tumor Suppressor by the Human Papillomavirus Type 16 E7 Oncoprotein Is Important for Functional Inactivation and Is Separable from Proteasomal Degradation of E7

2001 ◽  
Vol 75 (16) ◽  
pp. 7583-7591 ◽  
Author(s):  
Sonia L. Gonzalez ◽  
Matt Stremlau ◽  
Xi He ◽  
John R. Basile ◽  
Karl Münger
Keyword(s):  
Human Papillomavirus ◽  
Tumor Suppressor ◽  
Selection Process ◽  
State Level ◽  
Proteasomal Degradation ◽  
Biological Indicator ◽  
26S Proteasome ◽  
Amino Terminal ◽  
Retinoblastoma Tumor Suppressor ◽  
Retinoblastoma Tumor

ABSTRACT The steady-state level and metabolic half-life of retinoblastoma tumor suppressor protein pRB are decreased in cells that express high-risk human papillomavirus (HPV) E7 proteins. Here we show that pRB degradation is a direct activity of E7 and does not reflect a property of cell lines acquired during the selection process for E7 expression. An amino-terminal domain of E7 that does not directly contribute to pRB binding but is required for transformation is also necessary for E7-mediated pRB degradation. Treatment with inhibitors of the 26S proteasome not only blocks E7-mediated pRB degradation but also causes the stabilization of E7. Mutagenic analyses, however, reveal that the processes of proteasomal degradation of E7 and pRB are not linked processes. HPV type 16 E7 also targets the pRB-related proteins p107 and p130 for destabilization by a proteasome-dependent mechanism. Using the SAOS2 flat-cell assay as a biological indicator for pRB function, we demonstrate that pRB degradation, not solely binding, is important for the E7-induced inactivation of pRB.

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