A family study of psychotic symptomatology in schizophrenia, schizoaffective disorder, unipolar depression, and bipolar disorder

1985 ◽  
Vol 234 (5) ◽  
pp. 295-298 ◽  
Author(s):  
G. Winokur ◽  
C. Scharfetter ◽  
J. Angst
Keyword(s):  
Bipolar Disorder ◽  
Schizoaffective Disorder ◽  
Family Study ◽  
Unipolar Depression

scholarly journals Diagnostic conversion from unipolar depression to bipolar disorder, schizophrenia, or schizoaffective disorder: A nationwide prospective 15‐year register study on 43 495 inpatients

2020 ◽  
Vol 22 (6) ◽  
pp. 582-592
Author(s):  
Ilya Baryshnikov ◽  
Reijo Sund ◽  
Mauri Marttunen ◽  
Tanja Svirskis ◽  
Timo Partonen ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Schizoaffective Disorder ◽  
Unipolar Depression ◽  
Register Study

scholarly journals A 20-year multi-follow-up of hallucinations in schizophrenia, other psychotic, and mood disorders

2012 ◽  
Vol 43 (6) ◽  
pp. 1151-1160 ◽  
Author(s):  
V. M. Goghari ◽  
M. Harrow ◽  
L. S. Grossman ◽  
C. Rosen
Keyword(s):  
Bipolar Disorder ◽  
Psychiatric Disorders ◽  
Mood Disorders ◽  
Schizoaffective Disorder ◽  
Young Patients ◽  
Unipolar Depression ◽  
Diagnostic Feature ◽  
Longitudinal Course ◽  
Prospective Longitudinal

BackgroundHallucinations are a major aspect of psychosis and a diagnostic feature of both psychotic and mood disorders. However, the field lacks information regarding the long-term course of hallucinations in these disorders. Our goals were to determine the percentage of patients with hallucinations and the relationship between hallucinations and recovery, and work attainment.MethodThe present study was a prospective evaluation of the 20-year trajectory of hallucinations in 150 young patients: 51 schizophrenia, 25 schizoaffective, 25 bipolar with psychosis, and 49 unipolar depression. The patients were studied at an index phase of hospitalization for hallucinations, and then reassessed longitudinally at six subsequent follow-ups over 20 years.ResultsThe longitudinal course of hallucinations clearly differentiated between schizophrenia and bipolar disorder with psychosis, and suggested some diagnostic similarities between schizophrenia and schizoaffective disorder, and between bipolar disorder and schizoaffective disorder and depression. Frequent or persistent hallucinatory activity over the 20-year period was a feature of 40–45% of schizophrenia patients. The early presence of hallucinations predicted the lack of future periods of recovery in all patients. Increased hallucinatory activity was associated with reduced work attainment in all patients.ConclusionsThis study provides data on the prospective longitudinal course of hallucinations, which were previously unavailable to the field, and are one of the key features of psychosis in major psychiatric disorders. This information on the clinical course of major psychiatric disorders can inform accurate classification and diagnosis.

scholarly journals Creativity and mental disorder: Family study of 300 000 people with severe mental disorder

2011 ◽  
Vol 199 (5) ◽  
pp. 373-379 ◽  
Author(s):  
Simon Kyaga ◽  
Paul Lichtenstein ◽  
Marcus Boman ◽  
Christina Hultman ◽  
Niklas Långström ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Mental Disorder ◽  
Genetic Factors ◽  
Case Control Study ◽  
Family Study ◽  
Unipolar Depression ◽  
Patient Treatment ◽  
Healthy Siblings ◽  
Nested Case Control ◽  
Control Study

BackgroundThere is a long-standing belief that creativity is coupled with psychopathology.AimsTo test this alleged association and to investigate whether any such association is the result of environmental or genetic factors.MethodWe performed a nested case–control study based on Swedish registries. The likelihood of holding a creative occupation in individuals who had received in-patient treatment for schizophrenia, bipolar disorder or unipolar depression between 1973 and 2003 and their relatives without such a diagnosis was compared with that of controls.ResultsIndividuals with bipolar disorder and healthy siblings of people with schizophrenia or bipolar disorder were overrepresented in creative professions. People with schizophrenia had no increased rate of overall creative professions compared with controls, but an increased rate in the subgroup of artistic occupations. Neither individuals with unipolar depression nor their siblings differed from controls regarding creative professions.ConclusionsA familial cosegregation of both schizophrenia and bipolar disorder with creativity is suggested.

Co-occurrence and Cotransmission of Affective Disorders and Alcoholism in Families

1996 ◽  
Vol 168 (S30) ◽  
pp. 93-100 ◽  
Author(s):  
W. Maier ◽  
K. Merikangas
Keyword(s):  
Bipolar Disorder ◽  
General Population ◽  
Affective Disorders ◽  
Family Study ◽  
Unipolar Depression ◽  
Clinical Settings ◽  
Major Contributor ◽  
Modest Correlation

The analysis of patterns of co-occurrence and cotransmission of affective disorders and alcoholism in families may provide clues for understanding the excess comorbidity between these conditions in clinical settings and in the general population. This paper reports the results of a family study of the relatives of patients with bipolar disorder, unipolar depression and alcoholism, and combinations thereof. Excess comorbidity between affective disorders and alcoholism was observed in all groups of relatives. However, the sharing of familial aetiological components was not a major contributor to the excess comorbidity between affective disorders and alcoholism. Unipolar depression and alcoholism segregated independently in families, whereas a modest correlation between familial components of alcoholism and bipolar disorder was observed.

DSM-III criteria for affective disorders and schizophrenia : A preliminary appraisal using family interview findings

1988 ◽  
Vol 3 (3) ◽  
pp. 159-169
Author(s):  
H.G. Pope ◽  
B.M. Cohen ◽  
J.F. Lipinski ◽  
D. Yurgelun-Todd
Keyword(s):  
Bipolar Disorder ◽  
Affective Disorder ◽  
Schizoaffective Disorder ◽  
Psychotic Disorders ◽  
Diagnostic Interview ◽  
Diagnostic Categories ◽  
Family Interview ◽  
Small Test ◽  
Test Retest Reliability ◽  
Interview Studies

SummaryWe performed a blind family interview study of 226 first-degree relatives of 63 probands meeting DSM-III criteria for schizophrenia, schizoaffective disorder, and bipolar disorder, as diagnosed by the National Institute ot Mental Health Diagnostic Interview Schedule (DIS). A small test-retest reliability study demonstrated good agreement between the proband interviewer and the principal family interviewer for the major diagnostic categories of psychotic disorders. Excellent compliance was obtained, with 85% of living relatives interviewed personally.Three principal findings emerged front the study. First, as expected, bipolar disorder, as defined by DSM-III, displayed a strong familial comportent, comparable to that found by many studies using criteria other than those of DSM-III. Second, patients meeting DSM-III criteria for schizophrenia and schizoaffective disorder displayed a low familial prevalence of schizophrenia. Although initially suprising, this finding is in agreement with the results of several other recent lantily studies of schizophrenia. Upon comparing our results with those of other recent family studies of schizophrenia, it appears that the familial component in schizophrenia tnay be less than was estimated by earlier studies using older and “broader” definitions of schizophrenia.Third, we found that patients meeting DSM-III criteria for schizophrenia appeared genetically heterogeneous. Those who had displayed a superimposed full affective syndrome at some tinte in the course of their illness, together with those probands meeting DSM-III criteria for schizoaffective disorder, displayed a high familial prevalence of major affective disorder, similar to that found in the families of the bipolar probands. On the other hand, “pure” DSM-III schizophrenie probands, who had never experienced a superimposed full affective syndrome, displayed a low familial prevalence of major affective disorder, similar to that found in the general population. These findings favor the possibility that probands meeting DSM-III criteria for schizophrenia, but displaying a superimposed full affective syndrome, may in sonie cases have a disorder genetically relatcd to major affective disorder.Further prospective family interview studies, using DSM-III criteria and larger samples, will be necessary to test these preliminary impressions.

Different temperament and character dimensions correlate with panic disorder comorbidity in bipolar disorder and unipolar depression

2008 ◽  
Vol 22 (8) ◽  
pp. 1421-1426 ◽  
Author(s):  
Marco Mula ◽  
Stefano Pini ◽  
Palmiero Monteleone ◽  
Paolo Iazzetta ◽  
Matteo Preve ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Panic Disorder ◽  
Unipolar Depression
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