The use of decalcified granulated homologous cortical bone matrix in the correction of diaphyseal bone defect

1982 ◽  
Vol 99 (3) ◽  
pp. 199-207 ◽  
Author(s):  
Jos� B. Volpon ◽  
Camilo A. M. Xavier ◽  
Renato Pinto Con�alves
Keyword(s):  
Cortical Bone ◽  
Bone Defect ◽  
Bone Matrix ◽  
Diaphyseal Bone

scholarly journals The stability of impacted morsellized bone grafts in a metal cage under dynamic loaded conditions: an in vitro reconstruction of a segmental diaphyseal bone defect

2009 ◽  
Vol 129 (5) ◽  
pp. 575-581 ◽  
Author(s):  
Pieter H. J. Bullens ◽  
Bart H. W. Schreuder ◽  
Maarten C. de Waal Malefijt ◽  
Rene P. H. Veth ◽  
Pieter Buma ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Grafts ◽  
Diaphyseal Bone ◽  
The Stability

Accelerated repair of cortical bone defects using a synthetic extracellular matrix to deliver human demineralized bone matrix

2006 ◽  
Vol 24 (7) ◽  
pp. 1454-1462 ◽  
Author(s):  
Yanchun Liu ◽  
Shama Ahmad ◽  
Xiao Zheng Shu ◽  
R. Kent Sanders ◽  
Sally Anne Kopesec ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cortical Bone ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Bone Defects ◽  
Demineralized Bone

scholarly journals Histopathological and Radiographical Evaluation of Caprine Demineralized Bone Matrix in a Critical Ulnar Defect in a Rabbit Model

2021 ◽  
Author(s):  
Olawale Alimi Alimi ◽  
Adamu Abdul Abuabakar ◽  
Abubakar Sadiq Yakubu ◽  
Sani Abdullahi Shehu ◽  
Salman Zubairu Abdulkadir
Keyword(s):  
Bone Defect ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Rabbit Model ◽  
Negative Control ◽  
Autogenous Bone ◽  
Level Of Evidence ◽  
Defect Sites ◽  
Significant Difference ◽  
Demineralized Bone

Abstract Background: Caprine species satisfy the conditions of an ideal donor animal when compared to bovine species that has been extensively studied and commercialized for bone xenograft. Histopathological and radiological evaluations of caprine demineralized bone matrix (CDBM) were therefore carried out for fracture healing properties for its possible use in bone grafting procedures. Materials and Methods: Twenty-four rabbits were used for this study and were divided randomly into three groups of eight (n=8) rabbits each. Critical bone defect was created on the ulnar diaphysis under xylazine-ketamine anaesthesia for autogenous bone graft (ABG) group, CDBM group and the last group was left unfilled as negative control (NC). Immediate post-grafting radiograph was taken and repeated on days 14, 28, 42 and 56 to monitor the evidence of radiographic healing. The animals were euthanized on day 56 and defect sites were harvested for histopathology. Results: There was a progressive evidence of radiographic healing and bone formation in all the groups with significance difference (P=0.0064). When compared with ABG, NC differ significantly (P<0.0001) whereas the CDBM did not differ significantly (P=0.6765). The histopathology sections of ABG and CDBM showed normal bone tissue while the NC section was predominated by fibrous connective tissue. There was therefore an overall significant difference (P=0.0001) in which CDBM did not differ from ABG (P=0.2946) while NC did (P=0.0005). Conclusion: The ABG and CDBM groups showed a similar healing effect in the critical bone defect. Therefore, CDBM could be used as an effective alternative to ABG in orthopaedics to circumvent the limitations and complications associated with it. Level of Evidence: Not applicable.

Characterizing gait induced normal strains in a murine tibia cortical bone defect model

2010 ◽  
Vol 43 (14) ◽  
pp. 2765-2770 ◽  
Author(s):  
Jitendra Prasad ◽  
Brett P. Wiater ◽  
Sean E. Nork ◽  
Steven D. Bain ◽  
Ted S. Gross
Keyword(s):  
Cortical Bone ◽  
Bone Defect ◽  
Defect Model

Characterization of Bone Defect Repair in Young and Aged Rat Femur Induced by Xenogenic Demineralized Bone Matrix

2002 ◽  
Vol 73 (9) ◽  
pp. 1003-1009 ◽  
Author(s):  
Paola Torricelli ◽  
Milena Fini ◽  
Gianluca Giavaresi ◽  
Lia Rimondini ◽  
Roberto Giardino
Keyword(s):  
Bone Defect ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Rat Femur ◽  
Aged Rat ◽  
Bone Defect Repair ◽  
Defect Repair ◽  
Demineralized Bone

scholarly journals A Surrogate Measure of Cortical Bone Matrix Density by Long T2-Suppressed MRI

2015 ◽  
Vol 30 (12) ◽  
pp. 2229-2238 ◽  
Author(s):  
Alan C Seifert ◽  
Cheng Li ◽  
Suzanne L Wehrli ◽  
Felix W Wehrli
Keyword(s):  
Cortical Bone ◽  
Bone Matrix ◽  
Matrix Density ◽  
Surrogate Measure

Osteochondral Defect Repair by Demineralized Cortical Bone Matrix

2004 ◽  
Vol 427 ◽  
pp. S62-S66 ◽  
Author(s):  
Jizong Gao ◽  
David Knaack ◽  
Victor M Goldberg ◽  
Arnold I Caplan
Keyword(s):  
Cortical Bone ◽  
Osteochondral Defect ◽  
Bone Matrix ◽  
Defect Repair

scholarly journals Radiographic and histological study of perennial bone defect repair in rat calvaria after treatment with blocks of porous bovine organic graft material

2004 ◽  
Vol 12 (1) ◽  
pp. 62-69 ◽  
Author(s):  
Lucele Vieira Marins ◽  
Tania Mary Cestari ◽  
André Dotto Sottovia ◽  
José Mauro Granjeiro ◽  
Rumio Taga
Keyword(s):  
Bone Graft ◽  
Bone Defect ◽  
Bone Matrix ◽  
Graft Material ◽  
Body Type ◽  
Bone Defect Repair ◽  
Rat Calvaria ◽  
Local Bone ◽  
Blood Clots ◽  
Defect Repair

Over the last few years, various bone graft materials of bovine origin to be used in oromaxillofacial surgeries have entered the market. In the present study, we determined the capacity of a block organic bone graft material (Gen-ox, Baumer SA, Brazil) prepared from bovine cancellous bone to promote the repair of critical size bone injuries in rat calvaria. A transosseous defect measuring approximately 8mm in diameter was performed with a surgical trephine in the parietal bone of 25 rats. In 15 animals, the defects were filled with a block of graft material measuring 8mm in diameter and soaked in the animal's own blood, and in the other 10 animals the defects were only filled with blood clots. The calvariae of rats receiving the material were collected 1, 3 and 6 months after surgery, and those of animals receiving the blood clots were collected immediately and 6 months after surgery. During surgery, the graft material was found to be of easy handling and to adapt perfectly to the receptor bed after soaking in blood. The results showed that, in most animals treated, the material was slowly resorbed and served as a space filling and maintenance material, favoring angiogenesis, cell migration and adhesion, and bone neoformation from the borders of the lesion. However, a foreign body-type granulomatous reaction, with the presence of numerous giant cells preventing local bone neoformation, was observed in two animals of the 1-month subgroup and in one animal of the 3-month subgroup. These cases were interpreted as resulting from the absence of demineralization and the lack of removal of potential antigen factors during production of the biomaterial. We conclude that, with improvement in the quality control of the material production, block organic bone matrix will become a good alternative for bone defect repair in the oromaxillofacial region due to its high osteoconductive capacity.

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