Cytolytic T lymphocyte-defined retroviral antigens on normal cells: Encoding by the Akv-1 proviral locus

1986 ◽  
Vol 23 (2) ◽  
pp. 106-110 ◽  
Author(s):  
William R. Green ◽  
Robert F. Graziano
Keyword(s):  
T Lymphocyte ◽  
Normal Cells ◽  
Proviral Locus ◽  
Cytolytic T Lymphocyte

scholarly journals B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors.

1987 ◽  
Vol 166 (5) ◽  
pp. 1464-1470 ◽  
Author(s):  
J D Pfeifer ◽  
D T McKenzie ◽  
S L Swain ◽  
R W Dutton
Keyword(s):  
T Lymphocyte ◽  
Proliferative Response ◽  
Inhibitory Effect ◽  
Interleukin 4 ◽  
Con A ◽  
Endogenous Production ◽  
Proliferation And Differentiation ◽  
Cytolytic T Lymphocyte ◽  
Stimulatory Factor ◽  
Mitogenic Lectin

In this report, we demonstrate that IL-4 is sufficient to stimulate both the proliferation and differentiation of Lyt-2+, Ia- splenic CTL precursors stimulated with the mitogenic lectin Con A. The response to IL-4 and Con A was not dependent on a putative endogenous production of IL-2 within the cultures, as demonstrated by an absence of an inhibitory effect by an anti-IL-2-R blocking mAb. Our results indicate that IL-2 and IL-4 can support an equivalent proliferative response by lectin-stimulated Lyt-2+ T lymphocytes, while IL-4 is more efficacious in stimulating their differentiation into mature cytolytically active cells.

CD40 ligation restores cytolytic T lymphocyte response and eliminates fibrosarcoma in the peritoneum of mice lacking CD4+ T cells

2006 ◽  
Vol 55 (12) ◽  
pp. 1542-1552 ◽  
Author(s):  
Andrew Lodge ◽  
Ping Yu ◽  
Michael B. Nicholl ◽  
Ian E. Brown ◽  
Carl-Christian A. Jackson ◽  
...  
Keyword(s):  
T Cells ◽  
T Lymphocyte ◽  
Cd4 T Cells ◽  
Lymphocyte Response ◽  
Cd40 Ligation ◽  
Cytolytic T Lymphocyte

scholarly journals Use of Transgenic HLA A*0201/Kb and HHD II Mice To Evaluate Frequency of Cytomegalovirus IE1-Derived Peptide Usage in Eliciting Human CD8 Cytokine Response

2003 ◽  
Vol 77 (7) ◽  
pp. 4457-4462 ◽  
Author(s):  
Ghislaine Gallez-Hawkins ◽  
Maria C. Villacres ◽  
Xiuli Li ◽  
Margaret C. Sanborn ◽  
Norma A. Lomeli ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
T Lymphocyte ◽  
Gamma Interferon ◽  
Cytokine Response ◽  
Interferon Response ◽  
Peptide Specificity ◽  
Cytolytic T Lymphocyte ◽  
Prominent Response

ABSTRACT Unlike the pp65 protein of human cytomegalovirus (CMV), which has an immunodominant peptide, pp65495-503, recognized by human CD8+ cells in the context of HLA A*0201, the fine peptide specificity for CMV IE1 has shown no such immunodominance. With the use of transgenic HLA A*0201/Kb and HHD II mice, a selected pool of IE1 peptides, including IE1p256-264, IE1p297-304, and IE1p316-324, were shown to stimulate cytolytic T-lymphocyte lysis in the context of HLA A*0201. Based on an intracellular gamma interferon response, IE1p297-304, a previously unrecognized CD8 epitope, triggered a prominent response to CMV IE1 in HLA A*0201 subjects.

Human Cytolytic T-Lymphocyte Clones and Their Function-Associated Cell Surface Molecules

1985 ◽  
pp. 559-573 ◽  
Author(s):  
Alan M. Krensky ◽  
Steven J. Mentzer ◽  
Julia L. Greenstein ◽  
Mary Crimmins ◽  
Carol Clayberger ◽  
...  
Keyword(s):  
Cell Surface ◽  
T Lymphocyte ◽  
Cell Surface Molecules ◽  
Surface Molecules ◽  
Cytolytic T Lymphocyte

scholarly journals Differential Effects of Tea Extracts on Growth and Cytokine Production by Normal and Leukemic Human Leukocytes

2012 ◽  
Vol 2 (4) ◽  
pp. 72 ◽  
Author(s):  
Diana Bayer ◽  
Jonathon Jansen ◽  
Lisa A. Beltz
Keyword(s):  
T Lymphocytes ◽  
T Lymphocyte ◽  
Mononuclear Cells ◽  
Cytokine Production ◽  
Lymphoblastic Leukemia ◽  
Interleukin 2 ◽  
Leukemic Cells ◽  
Leukemia Cells ◽  
Peripheral Blood Mononuclear ◽  
Normal Cells

Background: Tea is one of the world’s most highly consumed beverages, second only to water. It is affordable and abundant and thus has great potential for improving health of those in both developed and developing areas. Green, oolong, and black teas differ in the extent of fermentation and types of bioactive polyphenols produced. Green tea and its major polyphenol decrease growth of some cancer cells and effect production of immune system cytokines. This study compares the effects of different types of tea extracts on viability and cytokine production by normal and leukemic human T lymphocytes. Generation of the toxic reactive oxygen species H2O2 by extracts was also examined.Methods: The Jurkat T lymphoblastic leukemia cells and mitogen-stimulated normal human peripheral blood mononuclear cells were used in this study. Cell viability was determined by (3-4,5-dimethylthiamizol-2-yl)-diphenyltetrazolium bromide) assay and production of interleukin-2 by Enzyme-Linked ImmunoSorbent Assay. Levels of H2O2 generated by tea extracts were determined using the xylenol-orange method.Results: We found that green, oolong, and black tea extracts differentially effect the growth and viability of T lymphoblastic leukemia cells and normal peripheral blood mononuclear cells, substantially decreasing both growth and viability of leukemic T lymphocytes and having much lesser effects on their normal counterparts. Tea extracts also had differential effects on the production of the T lymphocyte growth factor interleukin-2, significantly decreasing production by leukemic cells while having only minor effects on normal cells. All three extracts induced H2O2 generation, with green and oolong tea extracts having the greatest effect. Leukemic cells were much more susceptible to growth inhibition and killing by H2O2 than normal lymphocytes. Conclusions: The three tea extracts studied altered leukemic T lymphocyte functions, decreasing cell viability, growth, and production of a major cell growth factor and the H2O2 generated by solutions of extracts may be partially responsible. Normal cells were affected to a far lesser degree by tea extracts and are also more resistant to killing by H2O2 than leukemic cells. This study has implications for using tea extracts for chemotherapeutic and immunomodulatory purposes.Key Words: Tea extracts, interleukin-2, hydrogen peroxide, leukemia, T lymphocytes

CD4+, HLA class I-restricted, cytolytic T-lymphocyte clone against primary malignant melanoma cells

2000 ◽  
Vol 85 (2) ◽  
pp. 253-259 ◽  
Author(s):  
Rajasekharan Somasundaram ◽  
Paul Robbins ◽  
Dilip Moonka ◽  
Elwyn Loh ◽  
Francesco Marincola ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
T Lymphocyte ◽  
Hla Class I ◽  
Melanoma Cells ◽  
Class I ◽  
Primary Malignant Melanoma ◽  
Cytolytic T Lymphocyte ◽  
Lymphocyte Clone
Sign in / Sign up

Export Citation Format

Share Document